CRCGN011_HEPG2_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(4-ethoxyphenyl)urea 5.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

163 genes differentially expressed following the CRCGN011_HEPG2_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.5995
CHMP6 charged multivesicular body protein 6 7.5433
TIAM1 T-cell lymphoma invasion and metastasis 1 7.32985
GPER1 G protein-coupled estrogen receptor 1 6.4429
C2CD2 C2 calcium-dependent domain containing 2 5.31435
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.29685
PEX11A peroxisomal biogenesis factor 11 alpha 5.23182
PPARG peroxisome proliferator-activated receptor gamma 5.19515
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.9638
E2F2 E2F transcription factor 2 4.8341
NMU neuromedin U 4.81535
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.76655
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.007
MAP7 microtubule-associated protein 7 3.80643
STK10 serine/threonine kinase 10 3.69865
HEBP1 heme binding protein 1 3.61055
SLC75A1 solute carrier family 75 member 1 3.54685
SSBP2 single-stranded DNA binding protein 2 3.2573
MAST2 microtubule associated serine/threonine kinase 2 3.08823
APOD apolipoprotein D 2.96885
JADE2 jade family PHD finger 2 2.91568
CLCN7 chloride channel, voltage-sensitive 7 2.91543
UBE2A ubiquitin-conjugating enzyme E2A 2.91243
BIRC7 baculoviral IAP repeat containing 7 2.86215
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.7906
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.75945
POU4F1 POU class 4 homeobox 1 2.75408
DNASE1 deoxyribonuclease I 2.7114
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.7095
SCT secretin 2.60605
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.59145
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.58092
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.5777
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.5323
E4F1 E4F transcription factor 1 2.52185
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 2.50017
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 2.45915
HPS4 Hermansky-Pudlak syndrome 4 2.4405
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.42825
RERGL RERG/RAS-like 2.3733
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.3593
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) 2.35232
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.34485
LMF1 lipase maturation factor 1 2.34032
ZNF76 zinc finger protein 76 2.3384
ZNF589 zinc finger protein 589 2.3272
GPC5 glypican 5 2.32145
ZNF821 zinc finger protein 821 2.3209
ALOXE3 arachidonate lipoxygenase 3 2.31365
HLA-DRA major histocompatibility complex, class II, DR alpha 2.296
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.28585
KIF25 kinesin family member 25 2.25388
HSPA1A heat shock 70kDa protein 1A 2.2518
S100G S100 calcium binding protein G 2.2503
NRTN neurturin 2.2493
ADGRB2 adhesion G protein-coupled receptor B2 2.2483
GBX2 gastrulation brain homeobox 2 2.22495
RUNDC3B RUN domain containing 3B 2.21215
RBMXL2 RNA binding motif protein, X-linked-like 2 2.21135
SPATA31A3 SPATA31 subfamily A, member 3 2.20815
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.20265
CERS4 ceramide synthase 4 2.2025
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.19403
TBL3 transducin (beta)-like 3 2.18985
CRYBA4 crystallin, beta A4 2.18945
HKDC1 hexokinase domain containing 1 2.18795
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.18615
GEMIN8 gem (nuclear organelle) associated protein 8 2.1827
GPATCH8 G patch domain containing 8 2.1759
AMBRA1 autophagy/beclin-1 regulator 1 2.17083
SMAD1 SMAD family member 1 2.1682
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.1652
SIL1 SIL1 nucleotide exchange factor 2.1613
ALX4 ALX homeobox 4 2.1612
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.14371
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.14075
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.1382
CRYBG1 crystallin beta-gamma domain containing 1 2.1349
CDSN corneodesmosin 2.13247
SPATA31C1 SPATA31 subfamily C, member 1 2.11305
MREG melanoregulin 2.11255
WDTC1 WD and tetratricopeptide repeats 1 2.1041
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.1029
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.1009
SNX17 sorting nexin 17 2.09995
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.09845
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.09365
ARHGAP32 Rho GTPase activating protein 32 2.08555
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.0836
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.07985
RAB40C RAB40C, member RAS oncogene family 2.07905
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2.0751
CETN3 centrin, EF-hand protein, 3 2.07435
TBXT T-box transcription factor T 2.07015
CD34 CD34 molecule 2.0651
PLXND1 plexin D1 2.06117
PRSS3 protease, serine, 3 2.05118
AADAC arylacetamide deacetylase 2.0458
POU3F4 POU class 3 homeobox 4 2.04045
INSL3 insulin-like 3 (Leydig cell) 2.0377
UROS uroporphyrinogen III synthase 2.0375
ATG13 autophagy related 13 2.03677
P3H3 prolyl 3-hydroxylase 3 2.03575
GSTT4 glutathione S-transferase theta 4 2.0343
GFI1 growth factor independent 1 transcription repressor 2.02895
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.02635
HDAC11 histone deacetylase 11 2.0259
MSX2 msh homeobox 2 2.02387
TCTN3 tectonic family member 3 2.02385
CDO1 cysteine dioxygenase type 1 2.01845
MXD3 MAX dimerization protein 3 2.0139
PLEK2 pleckstrin 2 2.00595
NRG2 neuregulin 2 2.00338

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.2952
PCNA proliferating cell nuclear antigen -8.2787
GTPBP8 GTP-binding protein 8 (putative) -5.55765
LDHD lactate dehydrogenase D -5.4169
FASTKD5 FAST kinase domains 5 -5.2188
PCCB propionyl CoA carboxylase, beta polypeptide -4.70125
MRPS2 mitochondrial ribosomal protein S2 -4.70075
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.5741
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.447
HEATR1 HEAT repeat containing 1 -3.68083
GNAS GNAS complex locus -3.56664
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.4722
FBXL12 F-box and leucine-rich repeat protein 12 -3.42045
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.4133
STAT1 signal transducer and activator of transcription 1, 91kDa -3.21232
CCNB2 cyclin B2 -2.9901
RFC2 replication factor C (activator 1) 2, 40kDa -2.89367
RNF167 ring finger protein 167 -2.8549
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 -2.74265
DDRGK1 DDRGK domain containing 1 -2.66425
RBM34 RNA binding motif protein 34 -2.65615
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.55835
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.4686
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.4513
LY96 lymphocyte antigen 96 -2.431
WASHC4 WASH complex subunit 4 -2.37062
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.37053
ARRB2 arrestin, beta 2 -2.3568
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.34495
KIF3B kinesin family member 3B -2.3429
SEC23B Sec23 homolog B (S. cerevisiae) -2.33037
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.3267
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.2153
TASP1 taspase, threonine aspartase, 1 -2.19505
DBR1 debranching RNA lariats 1 -2.18175
PANK2 pantothenate kinase 2 -2.18005
ACLY ATP citrate lyase -2.16277
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.14555
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.1378
NOP10 NOP10 ribonucleoprotein -2.13125
TTF1 transcription termination factor, RNA polymerase I -2.12845
ZNF133 zinc finger protein 133 -2.1166
SEC16A SEC16 homolog A (S. cerevisiae) -2.11255
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.09325
LAMP5 lysosomal-associated membrane protein family, member 5 -2.0921
SOSTDC1 sclerostin domain containing 1 -2.03045
THBS2 thrombospondin 2 -2.0258
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.00855
NDEL1 nudE neurodevelopment protein 1-like 1 -2.00465