CRCGN011_HEPG2_24H:M20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-2-[4-(dimethylamino)phenyl]diazenesulfonate 10.86 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

85 genes differentially expressed following the CRCGN011_HEPG2_24H:M20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.5576
CSK c-src tyrosine kinase 5.523
RPP38 ribonuclease P/MRP 38kDa subunit 5.1362
CBR3 carbonyl reductase 3 5.08135
CIAO3 cytosolic iron-sulfur assembly component 3 5.0788
PNKP polynucleotide kinase 3'-phosphatase 4.80725
BZW2 basic leucine zipper and W2 domains 2 4.7398
EVL Enah/Vasp-like 4.73375
HMOX1 heme oxygenase 1 4.71785
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.46775
LOC122526780 uncharacterized LOC122526780 4.05095
CYCS cytochrome c, somatic 3.65575
GPER1 G protein-coupled estrogen receptor 1 3.61665
KDM5A lysine (K)-specific demethylase 5A 3.2826
COL11A1 collagen, type XI, alpha 1 3.02425
PIH1D1 PIH1 domain containing 1 3.0192
BIRC2 baculoviral IAP repeat containing 2 2.99335
GPATCH8 G patch domain containing 8 2.93342
DYNLT3 dynein, light chain, Tctex-type 3 2.9329
VGLL4 vestigial-like family member 4 2.89768
JADE2 jade family PHD finger 2 2.785
PHF21A PHD finger protein 21A 2.62335
BAMBI BMP and activin membrane-bound inhibitor 2.5805
SSBP2 single-stranded DNA binding protein 2 2.54238
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.48185
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.36215
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.32415
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.30885
IGFBP6 insulin-like growth factor binding protein 6 2.27045
TMEM106B transmembrane protein 106B 2.21245
KLHL9 kelch-like family member 9 2.12788
LBHD1 LBH domain containing 1 2.063
MTERF3 mitochondrial transcription termination factor 3 2.0479
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.01417

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
GNAS GNAS complex locus -7.35677
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.9307
COG2 component of oligomeric golgi complex 2 -5.6432
GDF15 growth differentiation factor 15 -5.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.9965
THAP11 THAP domain containing 11 -4.569
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.1522
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.13595
NGRN neugrin, neurite outgrowth associated -3.93325
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.4746
NRIP1 nuclear receptor interacting protein 1 -3.4051
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.29944
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.77195
OXA1L oxidase (cytochrome c) assembly 1-like -2.5766
HHAT hedgehog acyltransferase -2.5574
GLOD4 glyoxalase domain containing 4 -2.47585
BEX3 brain expressed X-linked 3 -2.30755
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.23965
GCG glucagon -2.236
SRD5A3 steroid 5 alpha-reductase 3 -2.2183
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -2.21065
EXOC5 exocyst complex component 5 -2.2069
PGM1 phosphoglucomutase 1 -2.20515
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.2037
RTN4 reticulon 4 -2.19918
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.1984
PCDHB3 protocadherin beta 3 -2.1864
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.1749
ZBTB25 zinc finger and BTB domain containing 25 -2.15785
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.1373
PNLIPRP2 pancreatic lipase-related protein 2 -2.1371
CTRL chymotrypsin-like -2.11965
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -2.1114
CPA1 carboxypeptidase A1 (pancreatic) -2.09665
SPANXB1 SPANX family, member B1 -2.08585
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.08313
GRID2 glutamate receptor, ionotropic, delta 2 -2.07902
HYDIN HYDIN, axonemal central pair apparatus protein -2.0613
RIT2 Ras-like without CAAX 2 -2.06085
PPT2 palmitoyl-protein thioesterase 2 -2.06
ZNF586 zinc finger protein 586 -2.0334
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.02848
GPR176 G protein-coupled receptor 176 -2.0266
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.02515
SCTR secretin receptor -2.0217
TEAD3 TEA domain family member 3 -2.01475
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.01275
HOXC13 homeobox C13 -2.008
F8A2 coagulation factor VIII-associated 2 -2.0059
HOXB2 homeobox B2 -2.00025