CRCGN011_HEPG2_24H:M21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-2-[4-(dimethylamino)phenyl]diazenesulfonate 5.43 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN011_HEPG2_24H:M21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.40475
INTS3 integrator complex subunit 3 5.20065
LCN2 lipocalin 2 5.0
BACE2 beta-site APP-cleaving enzyme 2 4.92845
KLHL21 kelch-like family member 21 4.67355
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.4329
EPHA3 EPH receptor A3 4.3837
CIAO3 cytosolic iron-sulfur assembly component 3 4.29235
PEX11A peroxisomal biogenesis factor 11 alpha 3.71777
DYNLT3 dynein, light chain, Tctex-type 3 3.4727
AMDHD2 amidohydrolase domain containing 2 3.3021
FPGS folylpolyglutamate synthase 3.1682
SSBP2 single-stranded DNA binding protein 2 3.14122
TIAM1 T-cell lymphoma invasion and metastasis 1 3.04262
PCDHB11 protocadherin beta 11 2.92755
GPATCH8 G patch domain containing 8 2.68377
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.6535
PTK2 protein tyrosine kinase 2 2.58978
COL11A1 collagen, type XI, alpha 1 2.57527
MCM3 minichromosome maintenance complex component 3 2.45915
ACBD3 acyl-CoA binding domain containing 3 2.45485
JADE2 jade family PHD finger 2 2.36555
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.35415
COPS7A COP9 signalosome subunit 7A 2.34775
NOSIP nitric oxide synthase interacting protein 2.3195
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.3189
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.29945
BAAT bile acid CoA:amino acid N-acyltransferase 2.2498
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.16757
OLFM4 olfactomedin 4 2.14515
CUL1 cullin 1 2.13905
MMP8 matrix metallopeptidase 8 2.11395
EMC8 ER membrane protein complex subunit 8 2.09225
GRTP1 growth hormone regulated TBC protein 1 2.06795
MTTP microsomal triglyceride transfer protein 2.02155

decreased expression

Symbol Name Standardized Value
HEATR1 HEAT repeat containing 1 -6.0464
CCDC86 coiled-coil domain containing 86 -5.26615
LDHD lactate dehydrogenase D -4.801
CD320 CD320 molecule -4.69355
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.66275
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.0718
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.9095
TLCD3A TLC domain containing 3A -3.52405
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.42665
PEG10 paternally expressed 10 -3.0605
SNX11 sorting nexin 11 -2.86562
NRIP1 nuclear receptor interacting protein 1 -2.72642
TCERG1 transcription elongation regulator 1 -2.68175
GRWD1 glutamate-rich WD repeat containing 1 -2.43945
IL13RA1 interleukin 13 receptor, alpha 1 -2.29654
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.27735
CCL22 chemokine (C-C motif) ligand 22 -2.18105
SLC35F2 solute carrier family 35, member F2 -2.14605
SH2D2A SH2 domain containing 2A -2.07205
TSPYL1 TSPY-like 1 -2.0241
ADORA2A adenosine A2a receptor -2.0147