CRCGN011_HEPG2_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-2-[4-(dimethylamino)phenyl]diazenesulfonate 1.36 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN011_HEPG2_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.4199
SQOR sulfide quinone oxidoreductase 5.3506
PNKP polynucleotide kinase 3'-phosphatase 5.2573
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.14055
PPARG peroxisome proliferator-activated receptor gamma 5.09075
STIMATE STIM activating enhancer 5.02995
NOTCH1 notch 1 5.00645
CSK c-src tyrosine kinase 4.66275
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.62075
UBQLN2 ubiquilin 2 4.58035
ADRB2 adrenoceptor beta 2, surface 4.5502
CXCR4 chemokine (C-X-C motif) receptor 4 3.81438
CCL2 chemokine (C-C motif) ligand 2 3.48305
WDTC1 WD and tetratricopeptide repeats 1 3.39975
ATP11B ATPase, class VI, type 11B 3.1488
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.12448
MAST2 microtubule associated serine/threonine kinase 2 3.0258
NOSIP nitric oxide synthase interacting protein 2.92045
JADE2 jade family PHD finger 2 2.69528
GRB10 growth factor receptor-bound protein 10 2.67865
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.56845
COL11A1 collagen, type XI, alpha 1 2.48172
UTP11 UTP11 small subunit processome component 2.45095
PRR16 proline rich 16 2.4378
SOCS2 suppressor of cytokine signaling 2 2.41877
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.369
CYCS cytochrome c, somatic 2.36715
CAPN10 calpain 10 2.3629
PRB2 proline-rich protein BstNI subfamily 2 2.32722
GPATCH8 G patch domain containing 8 2.20327
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.16525
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.1644
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.15045
EDA2R ectodysplasin A2 receptor 2.1
MEST mesoderm specific transcript 2.0873
EPHA3 EPH receptor A3 2.0812
CD40 CD40 molecule, TNF receptor superfamily member 5 2.08084
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.07387
TG thyroglobulin 2.0694
PTGFR prostaglandin F receptor (FP) 2.0663
PRB4 proline-rich protein BstNI subfamily 4 2.06085
CST2 cystatin SA 2.0605
RPL10L ribosomal protein L10-like 2.04565
SRFBP1 serum response factor binding protein 1 2.04265
GTF3A general transcription factor IIIA 2.03848
MAN2B2 mannosidase, alpha, class 2B, member 2 2.0289
PDCD6IP programmed cell death 6 interacting protein 2.02465
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.01875
PYCR1 pyrroline-5-carboxylate reductase 1 2.0046

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -5.48775
MRPS2 mitochondrial ribosomal protein S2 -5.0558
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9691
LDHD lactate dehydrogenase D -4.75265
CCNB2 cyclin B2 -4.5197
VAT1 vesicle amine transport 1 -4.45915
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.37995
TLCD3A TLC domain containing 3A -4.34985
ADI1 acireductone dioxygenase 1 -4.26905
CDC20 cell division cycle 20 -4.2155
HMG20B high mobility group 20B -4.13255
GDF15 growth differentiation factor 15 -3.8525
XPO7 exportin 7 -3.12397
GNAS GNAS complex locus -3.06174
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.01667
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.9174
CPNE3 copine III -2.5503
TBX2 T-box 2 -2.44295
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.42228
NPDC1 neural proliferation, differentiation and control, 1 -2.3868
ZNF135 zinc finger protein 135 -2.2632
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.23745
MCOLN3 mucolipin 3 -2.0759
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.068
PDE9A phosphodiesterase 9A -2.0457
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.0275