CRCGN011_HEPG2_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furan 2.38 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

115 genes differentially expressed following the CRCGN011_HEPG2_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.82795
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0932
PPARG peroxisome proliferator-activated receptor gamma 4.939
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.429
MAP7 microtubule-associated protein 7 3.99722
PRR15L proline rich 15-like 3.161
SSBP2 single-stranded DNA binding protein 2 3.12118
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.9989
PMM2 phosphomannomutase 2 2.76475
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.37847
PBK PDZ binding kinase 2.3402
HOOK2 hook microtubule-tethering protein 2 2.32337
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.2593
NDC1 NDC1 transmembrane nucleoporin 2.2563
JADE2 jade family PHD finger 2 2.14105
CLDN15 claudin 15 2.1326
SFXN1 sideroflexin 1 2.10425
PDE4B phosphodiesterase 4B, cAMP-specific 2.0729
ECT2 epithelial cell transforming 2 2.0655
KRT8 keratin 8, type II 2.04805
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.03892
LSG1 large 60S subunit nuclear export GTPase 1 2.00427

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.45531
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.4886
CDC20 cell division cycle 20 -5.31545
NUP85 nucleoporin 85kDa -5.1502
PCNA proliferating cell nuclear antigen -4.7455
UFM1 ubiquitin-fold modifier 1 -4.698
C2CD5 C2 calcium-dependent domain containing 5 -4.4135
FBXL12 F-box and leucine-rich repeat protein 12 -4.31405
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.97615
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.91535
EIF5 eukaryotic translation initiation factor 5 -3.78169
CCNB2 cyclin B2 -3.5426
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -3.43895
ARID5B AT rich interactive domain 5B (MRF1-like) -3.30935
SPAG4 sperm associated antigen 4 -3.058
TCERG1 transcription elongation regulator 1 -3.05345
TBCB tubulin folding cofactor B -3.02927
SAP30BP SAP30 binding protein -2.99115
RPS5 ribosomal protein S5 -2.82905
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.7331
RPS13 ribosomal protein S13 -2.6881
RPL19 ribosomal protein L19 -2.61265
RPL37 ribosomal protein L37 -2.6045
CAPNS1 calpain, small subunit 1 -2.59665
KRT34 keratin 34, type I -2.57945
RPS23 ribosomal protein S23 -2.5655
EXOSC8 exosome component 8 -2.54205
RPL30 ribosomal protein L30 -2.531
RPS27 ribosomal protein S27 -2.5147
PSENEN presenilin enhancer gamma secretase subunit -2.46945
RPL41 ribosomal protein L41 -2.4634
RPS8 ribosomal protein S8 -2.4603
RPL12 ribosomal protein L12 -2.45992
RPS18 ribosomal protein S18 -2.45615
CHIC2 cysteine-rich hydrophobic domain 2 -2.45555
TPT1 tumor protein, translationally-controlled 1 -2.44419
RPL23A ribosomal protein L23a -2.43889
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.4102
RPL7A ribosomal protein L7a -2.41005
RPL4 ribosomal protein L4 -2.38888
JPT1 Jupiter microtubule associated homolog 1 -2.38355
CETP cholesteryl ester transfer protein, plasma -2.376
GTF2IRD1 GTF2I repeat domain containing 1 -2.3739
RPS17 ribosomal protein S17 -2.35978
RPS15 ribosomal protein S15 -2.354
RPL32 ribosomal protein L32 -2.3445
ATRNL1 attractin-like 1 -2.32255
HLA-DMA major histocompatibility complex, class II, DM alpha -2.3178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.30305
PROSER1 proline and serine rich 1 -2.29725
RPL27 ribosomal protein L27 -2.29155
SUMO4 small ubiquitin-like modifier 4 -2.28665
RPL38 ribosomal protein L38 -2.265
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.26115
RPS12 ribosomal protein S12 -2.2601
RPS4X ribosomal protein S4, X-linked -2.25938
RPL27A ribosomal protein L27a -2.2583
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.24187
MRPL58 mitochondrial ribosomal protein L58 -2.23755
RPL9 ribosomal protein L9 -2.2337
PZP pregnancy-zone protein -2.2334
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 -2.228
HOXD10 homeobox D10 -2.21975
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.2178
ATP5PD ATP synthase peripheral stalk subunit d -2.18395
RPLP1 ribosomal protein, large, P1 -2.18115
GRB2 growth factor receptor-bound protein 2 -2.1611
RPS19 ribosomal protein S19 -2.1581
RPS16 ribosomal protein S16 -2.15045
RPLP0 ribosomal protein, large, P0 -2.14135
RPS3A ribosomal protein S3A -2.13078
MYLK3 myosin light chain kinase 3 -2.12725
MMP25 matrix metallopeptidase 25 -2.1267
RPL39 ribosomal protein L39 -2.1253
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.12275
GYS2 glycogen synthase 2 (liver) -2.1049
GPATCH1 G patch domain containing 1 -2.1044
RPS24 ribosomal protein S24 -2.0818
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.08095
RPS2 ribosomal protein S2 -2.0629
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.06065
RPL18 ribosomal protein L18 -2.0602
RPS10 ribosomal protein S10 -2.05288
MVP major vault protein -2.0476
TMEM147 transmembrane protein 147 -2.0473
RPS29 ribosomal protein S29 -2.04445
NOP10 NOP10 ribonucleoprotein -2.04295
RPL34 ribosomal protein L34 -2.0416
RPS15A ribosomal protein S15a -2.0414
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.0394
SOX11 SRY (sex determining region Y)-box 11 -2.03893
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.02635
ITGB1BP1 integrin beta 1 binding protein 1 -2.01715