CRCGN011_HEPG2_24H:N06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description furan 1.19 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN011_HEPG2_24H:N06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.887
GPER1 G protein-coupled estrogen receptor 1 6.26682
STAP2 signal transducing adaptor family member 2 5.8939
PPARG peroxisome proliferator-activated receptor gamma 5.3284
NOTCH1 notch 1 5.2197
UBQLN2 ubiquilin 2 5.185
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.1323
STIMATE STIM activating enhancer 5.0178
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 5.01742
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.57385
ABHD6 abhydrolase domain containing 6 4.27838
PEX11A peroxisomal biogenesis factor 11 alpha 4.10582
CARMIL1 capping protein regulator and myosin 1 linker 1 4.0472
EVL Enah/Vasp-like 3.88135
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.60985
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.31962
TP53BP2 tumor protein p53 binding protein 2 3.1963
RNF167 ring finger protein 167 3.05005
RRAGA Ras-related GTP binding A 3.0446
SIRT3 sirtuin 3 3.02982
PIH1D1 PIH1 domain containing 1 2.81005
TRIM21 tripartite motif containing 21 2.67355
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.47415
RMDN3 regulator of microtubule dynamics 3 2.42875
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.3956
IGFLR1 IGF-like family receptor 1 2.36045
PWWP3A PWWP domain containing 3A, DNA repair factor 2.3427
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.33625
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.3311
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.301
CIRBP cold inducible RNA binding protein 2.27553
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.25385
COL11A1 collagen, type XI, alpha 1 2.2128
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.19185
H2BC12 H2B clustered histone 12 2.1826
HRAS Harvey rat sarcoma viral oncogene homolog 2.16415
MED13 mediator complex subunit 13 2.16173
SREBF2 sterol regulatory element binding transcription factor 2 2.15943
BET1L Bet1 golgi vesicular membrane trafficking protein-like 2.15635
RAB5B RAB5B, member RAS oncogene family 2.1539
PCDH17 protocadherin 17 2.12485
CDC45 cell division cycle 45 2.1081
LRRN2 leucine rich repeat neuronal 2 2.1054
PGRMC2 progesterone receptor membrane component 2 2.10475
CCNF cyclin F 2.09973
TUBB6 tubulin, beta 6 class V 2.09335
TRAFD1 TRAF-type zinc finger domain containing 1 2.0842
BAHD1 bromo adjacent homology domain containing 1 2.05805
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 2.03315
KLF15 Kruppel-like factor 15 2.02225
ZNF222 zinc finger protein 222 2.02175
KIF17 kinesin family member 17 2.01805

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -7.4028
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.06225
HAT1 histone acetyltransferase 1 -5.436
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.2317
CCDC86 coiled-coil domain containing 86 -4.97235
TRIB3 tribbles pseudokinase 3 -4.92435
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.90575
NT5DC2 5'-nucleotidase domain containing 2 -4.78795
MAP7 microtubule-associated protein 7 -4.67443
GDF15 growth differentiation factor 15 -4.64705
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.1148
HMG20B high mobility group 20B -3.9562
YME1L1 YME1-like 1 ATPase -3.03483
OXA1L oxidase (cytochrome c) assembly 1-like -2.94125
GRN granulin -2.83255
ZMIZ1 zinc finger, MIZ-type containing 1 -2.631
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.5727
MAPK13 mitogen-activated protein kinase 13 -2.54945
TES testin LIM domain protein -2.52425
FAIM Fas apoptotic inhibitory molecule -2.44515
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.3941
MUTYH mutY homolog -2.33635
IGFBP6 insulin-like growth factor binding protein 6 -2.31175
FTO fat mass and obesity associated -2.30745
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.27645
SNX2 sorting nexin 2 -2.2748
GSE1 Gse1 coiled-coil protein -2.21205
NRIP1 nuclear receptor interacting protein 1 -2.11335
MMP3 matrix metallopeptidase 3 -2.1047
SP3 Sp3 transcription factor -2.0977
MRPL42 mitochondrial ribosomal protein L42 -2.06485
COG5 component of oligomeric golgi complex 5 -2.06255
NBPF19 neuroblastoma breakpoint family, member 19 -2.0578
PBK PDZ binding kinase -2.0521
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.0261
EIF5 eukaryotic translation initiation factor 5 -2.00315