CRCGN011_HEPG2_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN011_HEPG2_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.5409
C2CD2 C2 calcium-dependent domain containing 2 5.02395
PPARG peroxisome proliferator-activated receptor gamma 4.97645
MYLK myosin light chain kinase 4.7902
BACE2 beta-site APP-cleaving enzyme 2 4.78115
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.74975
GSTZ1 glutathione S-transferase zeta 1 3.97035
CHN1 chimerin 1 3.8178
SSBP2 single-stranded DNA binding protein 2 3.49878
KIF5C kinesin family member 5C 3.25918
COQ8A coenzyme Q8A 3.1746
HSPA1A heat shock 70kDa protein 1A 3.00885
RNF167 ring finger protein 167 3.006
GPER1 G protein-coupled estrogen receptor 1 2.8417
MAGEA6 melanoma antigen family A6 2.40185
FASTKD5 FAST kinase domains 5 2.33345
COPS7A COP9 signalosome subunit 7A 2.276
ARHGAP1 Rho GTPase activating protein 1 2.19227
RAB20 RAB20, member RAS oncogene family 2.036

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.1099
CCNB1 cyclin B1 -5.33725
DUSP6 dual specificity phosphatase 6 -5.01247
LDHD lactate dehydrogenase D -4.77505
UBE3C ubiquitin protein ligase E3C -4.74115
CD320 CD320 molecule -4.6345
LAP3 leucine aminopeptidase 3 -4.4874
BLVRA biliverdin reductase A -4.15613
KDM3A lysine (K)-specific demethylase 3A -3.88995
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.64718
GNAS GNAS complex locus -3.42069
MACF1 microtubule-actin crosslinking factor 1 -3.13892
OXA1L oxidase (cytochrome c) assembly 1-like -3.01185
FGFR4 fibroblast growth factor receptor 4 -2.99758
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.7912
IFRD2 interferon-related developmental regulator 2 -2.79103
NVL nuclear VCP-like -2.76315
LGMN legumain -2.4951
WASHC4 WASH complex subunit 4 -2.23052
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2115
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.1464
MN1 meningioma (disrupted in balanced translocation) 1 -2.1287
MAPK9 mitogen-activated protein kinase 9 -2.04682
KIF15 kinesin family member 15 -2.0082