CRCGN011_HEPG2_24H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN011_HEPG2_24H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 8.48992
CHMP6 charged multivesicular body protein 6 7.35405
MSRA methionine sulfoxide reductase A 5.09245
CSK c-src tyrosine kinase 5.08485
PPARG peroxisome proliferator-activated receptor gamma 5.05065
E2F2 E2F transcription factor 2 4.97705
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.81115
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.7325
KLHL21 kelch-like family member 21 4.5362
DYNLT3 dynein, light chain, Tctex-type 3 4.0574
TIAM1 T-cell lymphoma invasion and metastasis 1 3.98917
EVL Enah/Vasp-like 3.81455
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.8089
MAP7 microtubule-associated protein 7 3.67007
CYCS cytochrome c, somatic 3.6336
ZNF589 zinc finger protein 589 3.47233
WDTC1 WD and tetratricopeptide repeats 1 3.45642
PFKL phosphofructokinase, liver 3.2402
GPER1 G protein-coupled estrogen receptor 1 3.0031
ATP11B ATPase, class VI, type 11B 2.8496
DNASE1L3 deoxyribonuclease I-like 3 2.801
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.7889
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.7499
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.65652
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.59902
CHN1 chimerin 1 2.5018
DNAL4 dynein, axonemal, light chain 4 2.45575
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.3877
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.25762
BPHL biphenyl hydrolase-like (serine hydrolase) 2.257
FASTKD5 FAST kinase domains 5 2.25475
PARM1 prostate androgen-regulated mucin-like protein 1 2.2317
MED15 mediator complex subunit 15 2.2304
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.19145
FGD2 FYVE, RhoGEF and PH domain containing 2 2.15145
IFI27 interferon, alpha-inducible protein 27 2.14955
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.14285
CXCL14 chemokine (C-X-C motif) ligand 14 2.13065
EPHA3 EPH receptor A3 2.11563
H2BC12 H2B clustered histone 12 2.10532
LYPD3 LY6/PLAUR domain containing 3 2.0912
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.08663
PMM2 phosphomannomutase 2 2.0302
ITGB7 integrin, beta 7 2.01925
KHK ketohexokinase (fructokinase) 2.01237
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.0063

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -5.2136
PLK1 polo-like kinase 1 -5.1898
NT5DC2 5'-nucleotidase domain containing 2 -5.08275
KDM3A lysine (K)-specific demethylase 3A -4.9755
CD320 CD320 molecule -4.90495
CCNB1 cyclin B1 -4.3349
PECR peroxisomal trans-2-enoyl-CoA reductase -4.0408
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.96705
GNAS GNAS complex locus -3.71581
PCNA proliferating cell nuclear antigen -3.54785
NRIP1 nuclear receptor interacting protein 1 -3.34985
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.23708
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.9125
XPO7 exportin 7 -2.61975
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.61098
UBE3C ubiquitin protein ligase E3C -2.42015
RBM4B RNA binding motif protein 4B -2.3991
PMF1-BGLAP PMF1-BGLAP readthrough -2.3953
BARD1 BRCA1 associated RING domain 1 -2.37865
KDM3B lysine (K)-specific demethylase 3B -2.34298
SCCPDH saccharopine dehydrogenase (putative) -2.27693
TBC1D2 TBC1 domain family, member 2 -2.12995
CFAP20 cilia and flagella associated protein 20 -2.1255
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.0871
EIF5 eukaryotic translation initiation factor 5 -2.05735
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.05015