CRCGN011_HEPG2_24H:N09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

160 genes differentially expressed following the CRCGN011_HEPG2_24H:N09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
PNKP polynucleotide kinase 3'-phosphatase 5.79435
INTS3 integrator complex subunit 3 5.5452
MYLK myosin light chain kinase 5.13325
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0329
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.8167
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.45225
ABHD6 abhydrolase domain containing 6 4.09575
VGLL4 vestigial-like family member 4 3.86085
GATA3 GATA binding protein 3 3.39863
DHDDS dehydrodolichyl diphosphate synthase 3.3254
GPATCH8 G patch domain containing 8 3.32008
LYRM4 LYR motif containing 4 3.0428
SPRED2 sprouty-related, EVH1 domain containing 2 2.89783
SYF2 SYF2 pre-mRNA-splicing factor 2.8187
MATN4 matrilin 4 2.81155
GRB10 growth factor receptor-bound protein 10 2.7896
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.78865
CCNA1 cyclin A1 2.78745
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.75105
CTSL cathepsin L 2.71315
MORN1 MORN repeat containing 1 2.66745
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.65873
CRYL1 crystallin, lambda 1 2.61615
COL11A1 collagen, type XI, alpha 1 2.55967
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.55365
CLCN7 chloride channel, voltage-sensitive 7 2.54265
LGALS9C lectin, galactoside-binding, soluble, 9C 2.53755
ZNF629 zinc finger protein 629 2.52005
NBAS neuroblastoma amplified sequence 2.51755
P3H1 prolyl 3-hydroxylase 1 2.49055
PALM paralemmin 2.4835
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.48105
TNMD tenomodulin 2.47535
NOSIP nitric oxide synthase interacting protein 2.46915
MECR mitochondrial trans-2-enoyl-CoA reductase 2.4434
BIRC2 baculoviral IAP repeat containing 2 2.4427
CKAP2 cytoskeleton associated protein 2 2.42725
TBX19 T-box 19 2.42285
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.42175
GSTZ1 glutathione S-transferase zeta 1 2.39445
BIRC7 baculoviral IAP repeat containing 7 2.38635
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.38605
SLC66A2 solute carrier family 66 member 2 2.36875
GPER1 G protein-coupled estrogen receptor 1 2.36127
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.3373
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.313
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.3101
LOC122526780 uncharacterized LOC122526780 2.30885
PHB1 prohibitin 1 2.29752
LUC7L LUC7-like (S. cerevisiae) 2.2953
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.2872
IFT140 intraflagellar transport 140 2.28325
MTMR14 myotubularin related protein 14 2.2784
AMDHD2 amidohydrolase domain containing 2 2.2775
ISG20 interferon stimulated exonuclease gene 20kDa 2.26623
CCDC106 coiled-coil domain containing 106 2.2476
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 2.24022
MAST2 microtubule associated serine/threonine kinase 2 2.23897
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.2355
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.21895
TERF2 telomeric repeat binding factor 2 2.19925
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.1982
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 2.18945
CHPF2 chondroitin polymerizing factor 2 2.18878
RUFY1 RUN and FYVE domain containing 1 2.18415
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.17795
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.16978
BCR breakpoint cluster region 2.1632
ALX1 ALX homeobox 1 2.15105
CBY1 chibby homolog 1 (Drosophila) 2.1504
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.14435
PMF1-BGLAP PMF1-BGLAP readthrough 2.14055
TMEM43 transmembrane protein 43 2.1367
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.1366
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.12795
MFAP2 microfibrillar-associated protein 2 2.12315
UCMA upper zone of growth plate and cartilage matrix associated 2.12005
TARBP2 TAR (HIV-1) RNA binding protein 2 2.11195
DUSP2 dual specificity phosphatase 2 2.10705
POLL polymerase (DNA directed), lambda 2.1045
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.08105
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.0767
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.07655
ZCCHC10 zinc finger, CCHC domain containing 10 2.0666
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.06515
EMC3 ER membrane protein complex subunit 3 2.06445
COL11A2 collagen, type XI, alpha 2 2.06187
CD52 CD52 molecule 2.05998
TRIM25 tripartite motif containing 25 2.05885
ATG7 autophagy related 7 2.05035
SSTR5 somatostatin receptor 5 2.0491
FOXK2 forkhead box K2 2.0441
CCL27 chemokine (C-C motif) ligand 27 2.04325
TBL3 transducin (beta)-like 3 2.0403
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.03833
BPHL biphenyl hydrolase-like (serine hydrolase) 2.03745
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.03695
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.0362
VRK3 vaccinia related kinase 3 2.03538
KLHL1 kelch-like family member 1 2.0341
ELSPBP1 epididymal sperm binding protein 1 2.0249
WDR6 WD repeat domain 6 2.0169
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.0123
TIPRL TOR signaling pathway regulator 2.00965
DUX4 double homeobox 4 2.00385
TBXT T-box transcription factor T 2.00315

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
PCNA proliferating cell nuclear antigen -8.3117
THAP11 THAP domain containing 11 -5.47025
KDM3A lysine (K)-specific demethylase 3A -5.43995
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.03475
NUP93 nucleoporin 93kDa -4.98555
LDHD lactate dehydrogenase D -4.8253
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.67702
C2CD5 C2 calcium-dependent domain containing 5 -4.1803
EIF5 eukaryotic translation initiation factor 5 -3.94069
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.84132
MAPK13 mitogen-activated protein kinase 13 -3.80368
FGFR4 fibroblast growth factor receptor 4 -3.7092
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.60005
PECR peroxisomal trans-2-enoyl-CoA reductase -3.58655
NT5DC2 5'-nucleotidase domain containing 2 -3.5599
CCNB2 cyclin B2 -3.52745
GNAS GNAS complex locus -3.50556
RNF187 ring finger protein 187 -3.1201
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.92335
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.8639
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.72103
TENT5C terminal nucleotidyltransferase 5C -2.57565
DSTN destrin (actin depolymerizing factor) -2.55717
FOS FBJ murine osteosarcoma viral oncogene homolog -2.5475
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.5399
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.49975
H2AZ1 H2A.Z variant histone 1 -2.4963
ZNF586 zinc finger protein 586 -2.47875
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.4097
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.35675
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.3331
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.2967
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.27205
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.27045
HEXB hexosaminidase B (beta polypeptide) -2.1927
NOP56 NOP56 ribonucleoprotein -2.18628
RCOR3 REST corepressor 3 -2.1574
MAP2K1 mitogen-activated protein kinase kinase 1 -2.15445
DIXDC1 DIX domain containing 1 -2.14875
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.14405
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.1426
SSBP1 single-stranded DNA binding protein 1, mitochondrial -2.13675
GRN granulin -2.11205
PANK2 pantothenate kinase 2 -2.08455
RPH3A rabphilin 3A -2.06345
CDC25B cell division cycle 25B -2.05775
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.05507
SEC61G Sec61 gamma subunit -2.04345
MT1G metallothionein 1G -2.0412
PLK2 polo-like kinase 2 -2.0331
CCNH cyclin H -2.0179
SLC38A2 solute carrier family 38, member 2 -2.00187