CRCGN011_HEPG2_24H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(4-amino-2-nitroanilino)ethanol 21.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN011_HEPG2_24H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 5.5254
PPARG peroxisome proliferator-activated receptor gamma 5.36285
PLS1 plastin 1 4.7138
STK10 serine/threonine kinase 10 4.6848
RAI14 retinoic acid induced 14 4.58285
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.15075
SSBP2 single-stranded DNA binding protein 2 3.5746
LCN2 lipocalin 2 3.48475
GPATCH8 G patch domain containing 8 3.1892
SNX7 sorting nexin 7 3.01
PTK2 protein tyrosine kinase 2 2.84877
MEST mesoderm specific transcript 2.76345
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.67215
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.59215
MED15 mediator complex subunit 15 2.369
SH3D19 SH3 domain containing 19 2.35198
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.16765
OXCT1 3-oxoacid CoA transferase 1 2.1676
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.0743
DSCC1 DNA replication and sister chromatid cohesion 1 2.04025

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0135
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.93415
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.86005
MAP7 microtubule-associated protein 7 -4.63343
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.60892
CCDC86 coiled-coil domain containing 86 -4.4617
TLCD3A TLC domain containing 3A -4.34225
FGFR4 fibroblast growth factor receptor 4 -4.16395
UGDH UDP-glucose 6-dehydrogenase -3.938
PECR peroxisomal trans-2-enoyl-CoA reductase -3.51065
OXA1L oxidase (cytochrome c) assembly 1-like -3.3988
PCNA proliferating cell nuclear antigen -3.30175
TCTN1 tectonic family member 1 -3.112
KRT6B keratin 6B, type II -2.789
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.71545
CCDC170 coiled-coil domain containing 170 -2.68975
SNX11 sorting nexin 11 -2.64875
MAPK6 mitogen-activated protein kinase 6 -2.5746
DSG1 desmoglein 1 -2.5115
KLHL25 kelch-like family member 25 -2.38665
PGM1 phosphoglucomutase 1 -2.34555
EIF5 eukaryotic translation initiation factor 5 -2.33632
ANXA8L1 annexin A8-like 1 -2.32115
LMAN1 lectin, mannose-binding, 1 -2.2872
GRB2 growth factor receptor-bound protein 2 -2.2791
YJU2 YJU2 splicing factor homolog -2.27345
GPR12 G protein-coupled receptor 12 -2.26145
TUBA4B tubulin, alpha 4b -2.2588
TTPA tocopherol (alpha) transfer protein -2.24215
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.2334
TTYH1 tweety family member 1 -2.2321
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.2285
HR hair growth associated -2.22005
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -2.1688
RNF167 ring finger protein 167 -2.1497
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.1443
LGALS7B lectin, galactoside-binding, soluble, 7B -2.13345
CCDC33 coiled-coil domain containing 33 -2.1316
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.1043
PTPRT protein tyrosine phosphatase, receptor type, T -2.09025
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome -2.08698
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -2.0754
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.07105
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.05775
USP6NL USP6 N-terminal like -2.04795
ZMYND10 zinc finger, MYND-type containing 10 -2.04675
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -2.04422
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.0258
ITGB1BP1 integrin beta 1 binding protein 1 -2.01388
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A -2.0119
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.00376