CRCGN011_HEPG2_24H:N14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(4-amino-2-nitroanilino)ethanol 10.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN011_HEPG2_24H:N14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.0499
MYLK myosin light chain kinase 4.8702
ABHD6 abhydrolase domain containing 6 4.14642
PRKCH protein kinase C, eta 3.6095
EVL Enah/Vasp-like 3.3691
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.91535
TPD52L2 tumor protein D52-like 2 2.5823
DIPK1A divergent protein kinase domain 1A 2.4353
FZD7 frizzled class receptor 7 2.39022
MXRA7 matrix-remodelling associated 7 2.3516
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.28157
BIRC2 baculoviral IAP repeat containing 2 2.252
CYCS cytochrome c, somatic 2.2476
LYN LYN proto-oncogene, Src family tyrosine kinase 2.17305
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.06467
ACTA2 actin, alpha 2, smooth muscle, aorta 2.0563
FPGS folylpolyglutamate synthase 2.051
AMZ2 archaelysin family metallopeptidase 2 2.01395
METRN meteorin, glial cell differentiation regulator 2.00155

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.05925
GTPBP8 GTP-binding protein 8 (putative) -4.7903
SLC35F2 solute carrier family 35, member F2 -4.54235
MRPS16 mitochondrial ribosomal protein S16 -4.33155
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.1151
CCNB2 cyclin B2 -3.7949
OXA1L oxidase (cytochrome c) assembly 1-like -3.75765
PDHX pyruvate dehydrogenase complex, component X -3.60965
TM9SF3 transmembrane 9 superfamily member 3 -3.56955
LOC124907782 dual specificity protein phosphatase 22 -3.52575
PCNA proliferating cell nuclear antigen -3.27155
GHR growth hormone receptor -2.9791
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.84125
APIP APAF1 interacting protein -2.78655
EXT1 exostosin glycosyltransferase 1 -2.69833
HELLS helicase, lymphoid-specific -2.59235
PROS1 protein S (alpha) -2.5445
QSER1 glutamine and serine rich 1 -2.52675
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.41255
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.3829
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.37895
IL36R interleukin 36 receptor -2.37645
METTL4 methyltransferase like 4 -2.3423
HOXB2 homeobox B2 -2.33805
EIF5 eukaryotic translation initiation factor 5 -2.31815
IPO13 importin 13 -2.297
FBXO3 F-box protein 3 -2.2844
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.2745
CCNL1 cyclin L1 -2.2541
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1938
ZNF586 zinc finger protein 586 -2.1912
NAT10 N-acetyltransferase 10 (GCN5-related) -2.18535
SKI SKI proto-oncogene -2.1735
TRIM44 tripartite motif containing 44 -2.16645
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.1607
TSPAN9 tetraspanin 9 -2.1312
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.10385
EHF ets homologous factor -2.087
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.07495
SLC22A17 solute carrier family 22, member 17 -2.0546
CEP192 centrosomal protein 192kDa -2.05335
ENDOU endonuclease, polyU-specific -2.0504
NAXD NAD(P)HX dehydratase -2.0409
TBXAS1 thromboxane A synthase 1 (platelet) -2.0355
C2CD3 C2 calcium-dependent domain containing 3 -2.03175
CRISP3 cysteine-rich secretory protein 3 -2.02935
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 -2.02385
TMEM165 transmembrane protein 165 -2.02345
PELI1 pellino E3 ubiquitin protein ligase 1 -2.01085