| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-(4-amino-2-nitroanilino)ethanol 2.66 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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101 genes differentially expressed following the CRCGN011_HEPG2_24H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 7.05702 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.6466 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 5.1323 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.0007 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8827 |
| STIMATE | STIM activating enhancer | 4.7605 |
| MEF2C | myocyte enhancer factor 2C | 4.32813 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.23995 |
| NOSIP | nitric oxide synthase interacting protein | 4.15755 |
| CHN1 | chimerin 1 | 4.00075 |
| LCN2 | lipocalin 2 | 3.6119 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.37768 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.29205 |
| COQ8A | coenzyme Q8A | 3.1497 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.05215 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.0438 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 2.90727 |
| LAMB3 | laminin, beta 3 | 2.7286 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.70965 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 2.6316 |
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 2.5572 |
| RAMP3 | receptor (G protein-coupled) activity modifying protein 3 | 2.5218 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 | 2.5031 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.47662 |
| RALGDS | ral guanine nucleotide dissociation stimulator | 2.46665 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.42755 |
| CCL21 | chemokine (C-C motif) ligand 21 | 2.41415 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 2.4023 |
| ANKRD55 | ankyrin repeat domain 55 | 2.39495 |
| CYCS | cytochrome c, somatic | 2.3552 |
| CCL20 | chemokine (C-C motif) ligand 20 | 2.33295 |
| CRYGB | crystallin, gamma B | 2.3269 |
| EXOSC4 | exosome component 4 | 2.32305 |
| UBE2V2 | ubiquitin-conjugating enzyme E2 variant 2 | 2.28155 |
| ARHGAP15 | Rho GTPase activating protein 15 | 2.2516 |
| CHI3L2 | chitinase 3-like 2 | 2.23305 |
| ROBO4 | roundabout, axon guidance receptor, homolog 4 (Drosophila) | 2.1912 |
| CHEK2 | checkpoint kinase 2 | 2.18357 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 2.1636 |
| EMID1 | EMI domain containing 1 | 2.157 |
| PPA2 | pyrophosphatase (inorganic) 2 | 2.15095 |
| COCH | cochlin | 2.13155 |
| CTF1 | cardiotrophin 1 | 2.1294 |
| RALYL | RALY RNA binding protein-like | 2.11165 |
| UBASH3A | ubiquitin associated and SH3 domain containing A | 2.10545 |
| CD2 | CD2 molecule | 2.07035 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.06675 |
| NTAQ1 | N-terminal glutamine amidase 1 | 2.05475 |
| IPCEF1 | interaction protein for cytohesin exchange factors 1 | 2.04775 |
| MICALL2 | MICAL-like 2 | 2.017 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | 2.00877 |
| CD4 | CD4 molecule | 2.0074 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -5.0405 |
| CCDC86 | coiled-coil domain containing 86 | -5.03885 |
| GDF15 | growth differentiation factor 15 | -5.0 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.90715 |
| ZNF586 | zinc finger protein 586 | -4.8931 |
| SCAND1 | SCAN domain containing 1 | -4.75835 |
| SLC35F2 | solute carrier family 35, member F2 | -4.6369 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.37945 |
| CDC20 | cell division cycle 20 | -4.2155 |
| VAT1 | vesicle amine transport 1 | -4.17745 |
| HMG20B | high mobility group 20B | -4.04075 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.52635 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.17735 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -3.02492 |
| TCTN1 | tectonic family member 1 | -2.92355 |
| PCNA | proliferating cell nuclear antigen | -2.78925 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.6821 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.61695 |
| PRPF4 | pre-mRNA processing factor 4 | -2.59885 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.5807 |
| SNX11 | sorting nexin 11 | -2.5765 |
| MTX1 | metaxin 1 | -2.55785 |
| SUCO | SUN domain containing ossification factor | -2.55225 |
| PEG10 | paternally expressed 10 | -2.47977 |
| ZNF587B | zinc finger protein 587B | -2.47785 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.38137 |
| ANAPC2 | anaphase promoting complex subunit 2 | -2.33555 |
| YAP1 | Yes-associated protein 1 | -2.29255 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.28775 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -2.26585 |
| POGLUT2 | protein O-glucosyltransferase 2 | -2.2552 |
| ZNF587 | zinc finger protein 587 | -2.2529 |
| BLVRB | biliverdin reductase B | -2.22365 |
| ZNF304 | zinc finger protein 304 | -2.21865 |
| PHOSPHO2-KLHL23 | PHOSPHO2-KLHL23 readthrough | -2.20235 |
| PROS1 | protein S (alpha) | -2.16985 |
| RAB17 | RAB17, member RAS oncogene family | -2.1635 |
| UBA5 | ubiquitin-like modifier activating enzyme 5 | -2.1573 |
| WRN | Werner syndrome, RecQ helicase-like | -2.13815 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -2.13615 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.1218 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -2.1176 |
| PLA2G12A | phospholipase A2, group XIIA | -2.1142 |
| HECTD3 | HECT domain containing E3 ubiquitin protein ligase 3 | -2.1007 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -2.0746 |
| FRY | furry homolog (Drosophila) | -2.05233 |
| LASP1 | LIM and SH3 protein 1 | -2.05205 |
| KXD1 | KxDL motif containing 1 | -2.05105 |
| PCDHGA3 | protocadherin gamma subfamily A, 3 | -2.033 |
