CRCGN011_HEPG2_24H:N17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(4-amino-2-nitroanilino)ethanol 1.33 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN011_HEPG2_24H:N17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 7.3039
CHMP6 charged multivesicular body protein 6 5.75155
NMU neuromedin U 5.54565
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.12155
LCN2 lipocalin 2 5.0
E2F2 E2F transcription factor 2 4.60005
GPER1 G protein-coupled estrogen receptor 1 4.02548
MICALL1 MICAL-like 1 3.65905
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.50186
VGLL4 vestigial-like family member 4 3.10098
ADGRE5 adhesion G protein-coupled receptor E5 3.09505
TIAM1 T-cell lymphoma invasion and metastasis 1 2.88335
JADE2 jade family PHD finger 2 2.7183
CHN1 chimerin 1 2.70935
KLHL9 kelch-like family member 9 2.70285
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.6612
DUOX2 dual oxidase 2 2.57545
SCN3A sodium channel, voltage gated, type III alpha subunit 2.4857
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.46605
NANOS2 nanos homolog 2 (Drosophila) 2.46025
RLBP1 retinaldehyde binding protein 1 2.3436
CCL4 chemokine (C-C motif) ligand 4 2.32675
CCNF cyclin F 2.28125
SUSD5 sushi domain containing 5 2.2228
CRELD2 cysteine-rich with EGF-like domains 2 2.194
CD40 CD40 molecule, TNF receptor superfamily member 5 2.1812
CDC45 cell division cycle 45 2.18055
CYCS cytochrome c, somatic 2.171
APOL1 apolipoprotein L, 1 2.146
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.11455
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.1139
SNX10 sorting nexin 10 2.11305
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.04505
NOSIP nitric oxide synthase interacting protein 2.00985

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.8012
UGDH UDP-glucose 6-dehydrogenase -5.2085
PCCB propionyl CoA carboxylase, beta polypeptide -4.9278
MRPS2 mitochondrial ribosomal protein S2 -4.89575
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.68205
MAP7 microtubule-associated protein 7 -4.62112
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.2042
EIF5 eukaryotic translation initiation factor 5 -4.04802
MAPK13 mitogen-activated protein kinase 13 -3.94313
OXA1L oxidase (cytochrome c) assembly 1-like -3.5575
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.51543
PEG10 paternally expressed 10 -3.48187
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.40957
GNAS GNAS complex locus -3.40019
TLCD3A TLC domain containing 3A -3.3901
PCNA proliferating cell nuclear antigen -3.2109
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.98325
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.84325
DEPTOR DEP domain containing MTOR-interacting protein -2.7357
RNF167 ring finger protein 167 -2.6248
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.57645
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.55577
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.53832
OSBPL1A oxysterol binding protein-like 1A -2.48298
IPO13 importin 13 -2.47095
EXT1 exostosin glycosyltransferase 1 -2.34897
DACT1 dishevelled-binding antagonist of beta-catenin 1 -2.2776
VEGFC vascular endothelial growth factor C -2.25935
EXPH5 exophilin 5 -2.15585
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.14377
NTM neurotrimin -2.14085
SLC16A6 solute carrier family 16, member 6 -2.13755
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -2.10965
MTX2 metaxin 2 -2.10655
PADI2 peptidyl arginine deiminase, type II -2.1016
ZNF134 zinc finger protein 134 -2.0927
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.09095
NUP58 nucleoporin 58 -2.062
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.0246