CRCGN011_HEPG2_24H:N19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 19.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN011_HEPG2_24H:N19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.79285
KIFBP kinesin family binding protein 5.69215
MSRA methionine sulfoxide reductase A 5.6027
CSK c-src tyrosine kinase 5.48555
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.051
CHMP6 charged multivesicular body protein 6 4.844
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.89607
EPN2 epsin 2 3.813
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.75065
MAP7 microtubule-associated protein 7 3.67183
ABHD4 abhydrolase domain containing 4 3.5609
LCN2 lipocalin 2 3.5168
WDTC1 WD and tetratricopeptide repeats 1 3.46353
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.1399
IQGAP1 IQ motif containing GTPase activating protein 1 3.12088
AMDHD2 amidohydrolase domain containing 2 3.0542
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.00675
JUN jun proto-oncogene 2.72287
CTSL cathepsin L 2.68385
VAT1 vesicle amine transport 1 2.66055
ADAM10 ADAM metallopeptidase domain 10 2.6579
DDIT4 DNA-damage-inducible transcript 4 2.4482
ANO1 anoctamin 1, calcium activated chloride channel 2.42785
SKIC2 SKI2 subunit of superkiller complex 2.39725
EIF6 eukaryotic translation initiation factor 6 2.38025
RAB4A RAB4A, member RAS oncogene family 2.35405
GIPC1 GIPC PDZ domain containing family, member 1 2.326
LOC122526780 uncharacterized LOC122526780 2.2934
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.2694
HMGA1 high mobility group AT-hook 1 2.26805
DXO decapping exoribonuclease 2.10452
SCAMP2 secretory carrier membrane protein 2 2.08645
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.06435
CTPS1 CTP synthase 1 2.0438
EPS8L2 EPS8-like 2 2.0419
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.00933
CEMIP2 cell migration inducing hyaluronidase 2 2.00675
SMIM40 small integral membrane protein 40 2.0063

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -10.0
CCNB1 cyclin B1 -5.5206
ISOC1 isochorismatase domain containing 1 -5.4504
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.35775
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.19035
ADI1 acireductone dioxygenase 1 -5.08225
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.04595
GOLT1B golgi transport 1B -4.9716
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.89775
CCNB2 cyclin B2 -4.81975
TLCD3A TLC domain containing 3A -4.57545
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.4731
ARID5B AT rich interactive domain 5B (MRF1-like) -4.42895
UGDH UDP-glucose 6-dehydrogenase -4.29725
NGRN neugrin, neurite outgrowth associated -3.73665
GDF15 growth differentiation factor 15 -3.51695
WASHC4 WASH complex subunit 4 -3.44077
CHEK1 checkpoint kinase 1 -3.29032
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.01988
TUBGCP5 tubulin, gamma complex associated protein 5 -2.76725
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.69455
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.65225
DERA deoxyribose-phosphate aldolase (putative) -2.51685
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 -2.48435
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.40385
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.4037
PRPF4 pre-mRNA processing factor 4 -2.3649
OXA1L oxidase (cytochrome c) assembly 1-like -2.361
LOC124907782 dual specificity protein phosphatase 22 -2.3164
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.29515
ISCU iron-sulfur cluster assembly enzyme -2.2637
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.2195
RXRA retinoid X receptor, alpha -2.21623
CDK1 cyclin-dependent kinase 1 -2.21122
PARPBP PARP1 binding protein -2.2108
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.17775
CROT carnitine O-octanoyltransferase -2.17615
TRDN triadin -2.1742
FMNL3 formin-like 3 -2.15985
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.15945
JAK2 Janus kinase 2 -2.14945
FBXL8 F-box and leucine-rich repeat protein 8 -2.12825
CEP152 centrosomal protein 152kDa -2.121
KIF2C kinesin family member 2C -2.11958
ARL15 ADP-ribosylation factor-like 15 -2.117
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.09757
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 -2.09325
E2F8 E2F transcription factor 8 -2.09115
EXOSC10 exosome component 10 -2.0875
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.0863
RFC2 replication factor C (activator 1) 2, 40kDa -2.08535
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.081
TSPAN8 tetraspanin 8 -2.07155
PTPRR protein tyrosine phosphatase, receptor type, R -2.07017
PLK1 polo-like kinase 1 -2.052
NLRP4 NLR family, pyrin domain containing 4 -2.01855
NUP155 nucleoporin 155kDa -2.0065