CRCGN011_HEPG2_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 4.96 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

123 genes differentially expressed following the CRCGN011_HEPG2_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
CXCL2 chemokine (C-X-C motif) ligand 2 5.3476
CSK c-src tyrosine kinase 5.1477
MYLK myosin light chain kinase 5.0
CCDC92 coiled-coil domain containing 92 4.96675
CIAO3 cytosolic iron-sulfur assembly component 3 4.91665
TLR4 toll-like receptor 4 4.8605
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8466
CCL2 chemokine (C-C motif) ligand 2 4.8295
NMU neuromedin U 4.7328
MOK MOK protein kinase 4.62545
GARRE1 granule associated Rac and RHOG effector 1 4.35875
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.1917
E2F2 E2F transcription factor 2 4.1489
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.46855
PLSCR3 phospholipid scramblase 3 3.40207
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.3683
KDM5A lysine (K)-specific demethylase 5A 3.29278
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.8816
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.74865
SSBP2 single-stranded DNA binding protein 2 2.73955
SETD1B SET domain containing 1B 2.73445
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.66223
ASCC3 activating signal cointegrator 1 complex subunit 3 2.63615
RPP38 ribonuclease P/MRP 38kDa subunit 2.6253
NKTR natural killer cell triggering receptor 2.55096
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.5181
ATAD2 ATPase family, AAA domain containing 2 2.49845
SYNE2 spectrin repeat containing, nuclear envelope 2 2.45295
PIH1D1 PIH1 domain containing 1 2.4183
ZNF22 zinc finger protein 22 2.41385
KRT17 keratin 17, type I 2.4046
CLEC2D C-type lectin domain family 2, member D 2.38245
COL11A1 collagen, type XI, alpha 1 2.3658
KLHL9 kelch-like family member 9 2.3346
ADAM10 ADAM metallopeptidase domain 10 2.33188
VTCN1 V-set domain containing T cell activation inhibitor 1 2.32945
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.28905
XPC xeroderma pigmentosum, complementation group C 2.27
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.22665
CRELD2 cysteine-rich with EGF-like domains 2 2.2177
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.2171
NCOA3 nuclear receptor coactivator 3 2.21397
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.20995
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.1948
ITGB7 integrin, beta 7 2.1883
FYB1 FYN binding protein 1 2.1848
THNSL1 threonine synthase-like 1 (S. cerevisiae) 2.1665
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.16115
WDR73 WD repeat domain 73 2.1551
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.1513
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2.14965
MLF2 myeloid leukemia factor 2 2.13805
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.13715
C1RL complement component 1, r subcomponent-like 2.12565
TERF2 telomeric repeat binding factor 2 2.1194
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.1171
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.08345
SQOR sulfide quinone oxidoreductase 2.0726
TTC31 tetratricopeptide repeat domain 31 2.0617
ZMYM2 zinc finger, MYM-type 2 2.056
ANXA8L1 annexin A8-like 1 2.05385
ADNP activity-dependent neuroprotector homeobox 2.0458
CTTN cortactin 2.0205
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.0131
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.01027
PREPL prolyl endopeptidase-like 2.00263

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.2768
PCNA proliferating cell nuclear antigen -8.2512
FGFR4 fibroblast growth factor receptor 4 -7.6333
GADD45A growth arrest and DNA-damage-inducible, alpha -5.42075
ACOT9 acyl-CoA thioesterase 9 -5.33725
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.31775
FBXL12 F-box and leucine-rich repeat protein 12 -4.7858
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.75215
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
CD320 CD320 molecule -4.66275
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.3346
CCNB2 cyclin B2 -4.161
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -4.12345
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.06775
TLCD3A TLC domain containing 3A -4.04675
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.8934
NRIP1 nuclear receptor interacting protein 1 -3.61527
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.61343
SESN1 sestrin 1 -3.42455
MAPK13 mitogen-activated protein kinase 13 -3.31323
LOC124907782 dual specificity protein phosphatase 22 -3.16895
CTNND1 catenin (cadherin-associated protein), delta 1 -3.06073
TOR1A torsin family 1, member A (torsin A) -2.82363
PGM1 phosphoglucomutase 1 -2.77365
MTFR1 mitochondrial fission regulator 1 -2.7723
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.74705
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.74425
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.68582
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.67825
IPO13 importin 13 -2.67795
DIXDC1 DIX domain containing 1 -2.50415
HPGDS hematopoietic prostaglandin D synthase -2.47985
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.4463
NMRK1 nicotinamide riboside kinase 1 -2.32795
AKAP3 A kinase (PRKA) anchor protein 3 -2.28
PRDX4 peroxiredoxin 4 -2.2614
FERMT1 fermitin family member 1 -2.25852
EMC6 ER membrane protein complex subunit 6 -2.2273
CENPU centromere protein U -2.19765
IQCE IQ motif containing E -2.1944
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.18495
VAV1 vav 1 guanine nucleotide exchange factor -2.17685
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1712
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.16655
PRM2 protamine 2 -2.15815
MAP2K5 mitogen-activated protein kinase kinase 5 -2.10405
IRAK1 interleukin-1 receptor-associated kinase 1 -2.0913
IGFALS insulin-like growth factor binding protein, acid labile subunit -2.08905
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.07835
ALOX5AP arachidonate 5-lipoxygenase-activating protein -2.0738
REXO5 RNA exonuclease 5 -2.04437
UEVLD UEV and lactate/malate dehyrogenase domains -2.0364
STX10 syntaxin 10 -2.03245
LOC128966597 MAL-like protein -2.03195
SH3BP1 SH3-domain binding protein 1 -2.0047
NCF4 neutrophil cytosolic factor 4, 40kDa -2.00388