CRCGN011_HEPG2_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN011_HEPG2_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 6.0313
CARMIL1 capping protein regulator and myosin 1 linker 1 5.71885
CBR3 carbonyl reductase 3 5.709
TLR4 toll-like receptor 4 5.4785
CHMP6 charged multivesicular body protein 6 5.274
SNAP25 synaptosomal-associated protein, 25kDa 5.17905
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.64905
STK10 serine/threonine kinase 10 4.05347
LCN2 lipocalin 2 3.5495
TIAM1 T-cell lymphoma invasion and metastasis 1 3.47773
CGRRF1 cell growth regulator with ring finger domain 1 3.33575
CCL2 chemokine (C-C motif) ligand 2 3.2961
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.2723
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.6846
NENF neudesin neurotrophic factor 2.62628
DHDDS dehydrodolichyl diphosphate synthase 2.58498
WRN Werner syndrome, RecQ helicase-like 2.558
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.5122
BIRC2 baculoviral IAP repeat containing 2 2.42075
CHN1 chimerin 1 2.3859
CKS1B CDC28 protein kinase regulatory subunit 1B 2.38135
ADAT1 adenosine deaminase, tRNA-specific 1 2.3761
JADE2 jade family PHD finger 2 2.36277
ITGA7 integrin, alpha 7 2.34713
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.22055
HLA-DRA major histocompatibility complex, class II, DR alpha 2.18362
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.142
TIMP4 TIMP metallopeptidase inhibitor 4 2.11975
CHEK2 checkpoint kinase 2 2.11002
TTC27 tetratricopeptide repeat domain 27 2.09965
CST3 cystatin C 2.0981
DCTPP1 dCTP pyrophosphatase 1 2.06435
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.06265
OXSR1 oxidative stress responsive 1 2.04555
TAC4 tachykinin 4 (hemokinin) 2.04095
WDR43 WD repeat domain 43 2.01785
FPGS folylpolyglutamate synthase 2.00275

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.30938
DUSP6 dual specificity phosphatase 6 -5.79242
PECR peroxisomal trans-2-enoyl-CoA reductase -5.0807
ZDHHC6 zinc finger, DHHC-type containing 6 -4.9763
MRPS2 mitochondrial ribosomal protein S2 -4.7777
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.72175
MAP7 microtubule-associated protein 7 -4.64468
KDM3A lysine (K)-specific demethylase 3A -4.60095
TRAP1 TNF receptor-associated protein 1 -4.25155
LDHD lactate dehydrogenase D -4.2365
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.19635
OXA1L oxidase (cytochrome c) assembly 1-like -4.11455
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.97555
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.8101
MAPK13 mitogen-activated protein kinase 13 -3.5737
CTNND1 catenin (cadherin-associated protein), delta 1 -3.01597
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.90483
NGRN neugrin, neurite outgrowth associated -2.85505
CSRNP3 cysteine-serine-rich nuclear protein 3 -2.8522
STAT1 signal transducer and activator of transcription 1, 91kDa -2.71472
SESN1 sestrin 1 -2.5559
TACR1 tachykinin receptor 1 -2.40436
STAP1 signal transducing adaptor family member 1 -2.4008
RGCC regulator of cell cycle -2.3844
TMEM204 transmembrane protein 204 -2.2727
MC4R melanocortin 4 receptor -2.2456
FAM163A family with sequence similarity 163, member A -2.24145
HOXC13 homeobox C13 -2.23845
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.22665
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.2237
CCDC28A coiled-coil domain containing 28A -2.2005
SART1 squamous cell carcinoma antigen recognized by T cells -2.17305
LMTK2 lemur tyrosine kinase 2 -2.14675
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.13815
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.1039
VEZT vezatin, adherens junctions transmembrane protein -2.10325
ADGRF5 adhesion G protein-coupled receptor F5 -2.0988
UBXN2B UBX domain protein 2B -2.0987
LIME1 Lck interacting transmembrane adaptor 1 -2.09235
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 -2.0684
SLC45A2 solute carrier family 45, member 2 -2.06295
TLCD3A TLC domain containing 3A -2.048
OCA2 oculocutaneous albinism II -2.0469
SCARB1 scavenger receptor class B, member 1 -2.04688
TDRD3 tudor domain containing 3 -2.02003
ZNF112 zinc finger protein 112 -2.0046