CRCGN011_HEPG2_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN011_HEPG2_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 10.0
CSK c-src tyrosine kinase 5.35735
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.98443
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.85425
CIAO3 cytosolic iron-sulfur assembly component 3 4.71165
AMDHD2 amidohydrolase domain containing 2 4.5981
STK10 serine/threonine kinase 10 4.36155
ADRB2 adrenoceptor beta 2, surface 4.19965
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.1179
DYNLT3 dynein, light chain, Tctex-type 3 3.4815
TLR4 toll-like receptor 4 3.46965
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.4286
KDM5A lysine (K)-specific demethylase 5A 3.32847
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.20045
SSBP2 single-stranded DNA binding protein 2 3.15503
ATP11B ATPase, class VI, type 11B 3.1138
HLA-DRA major histocompatibility complex, class II, DR alpha 2.71005
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.67885
PRR15L proline rich 15-like 2.6731
MEST mesoderm specific transcript 2.6212
EVL Enah/Vasp-like 2.55405
DENND2D DENN/MADD domain containing 2D 2.38035
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.36042
CHN1 chimerin 1 2.31095
TREM1 triggering receptor expressed on myeloid cells 1 2.2957
KAT6A K(lysine) acetyltransferase 6A 2.28545
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 2.26215
GCC1 GRIP and coiled-coil domain containing 1 2.2602
TMEM208 transmembrane protein 208 2.24325
ZNF107 zinc finger protein 107 2.20745
H2BC12 H2B clustered histone 12 2.20307
JADE2 jade family PHD finger 2 2.1331
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 2.12495
ZNHIT1 zinc finger, HIT-type containing 1 2.10485
TRIM9 tripartite motif containing 9 2.0974
ERH enhancer of rudimentary homolog (Drosophila) 2.0941
GPATCH8 G patch domain containing 8 2.0646
ARHGAP25 Rho GTPase activating protein 25 2.0483
NUP205 nucleoporin 205kDa 2.0402
DMTF1 cyclin D binding myb-like transcription factor 1 2.03468
FCMR Fc fragment of IgM receptor 2.02665
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.0133

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.2459
CDC20 cell division cycle 20 -5.2979
CCDC86 coiled-coil domain containing 86 -5.13895
GTPBP8 GTP-binding protein 8 (putative) -5.0312
DNM1L dynamin 1-like -4.4803
KDM3A lysine (K)-specific demethylase 3A -4.14725
FGFR4 fibroblast growth factor receptor 4 -4.03722
NGRN neugrin, neurite outgrowth associated -3.3807
MAPK13 mitogen-activated protein kinase 13 -3.3746
CD58 CD58 molecule -3.36865
YME1L1 YME1-like 1 ATPase -3.2451
TLCD3A TLC domain containing 3A -2.78275
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.69806
CCNH cyclin H -2.52105
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.3534
MAP2K5 mitogen-activated protein kinase kinase 5 -2.26707
VDAC1 voltage-dependent anion channel 1 -2.26538
GRHL2 grainyhead-like 2 (Drosophila) -2.20255
IFT81 intraflagellar transport 81 -2.19745
RNF123 ring finger protein 123 -2.1749
SEPTIN10 septin 10 -2.15935
OXA1L oxidase (cytochrome c) assembly 1-like -2.07145
MYBPC2 myosin binding protein C, fast type -2.04635
SLC35A5 solute carrier family 35, member A5 -2.01905
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.0074