CRCGN011_HEPG2_24H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

197 genes differentially expressed following the CRCGN011_HEPG2_24H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 6.7721
DDIT4 DNA-damage-inducible transcript 4 6.06565
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.88415
TAC4 tachykinin 4 (hemokinin) 5.7228
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.55345
TRIB3 tribbles pseudokinase 3 5.4138
CHMP6 charged multivesicular body protein 6 5.18785
INTS3 integrator complex subunit 3 5.11535
H2BC12 H2B clustered histone 12 5.02602
CTSL cathepsin L 4.95175
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.7021
AMDHD2 amidohydrolase domain containing 2 4.6754
BACE2 beta-site APP-cleaving enzyme 2 4.52875
PLS1 plastin 1 4.52535
MAP7 microtubule-associated protein 7 4.43555
MOK MOK protein kinase 4.31615
CNPY3 canopy FGF signaling regulator 3 4.29635
BZW2 basic leucine zipper and W2 domains 2 4.122
CHN1 chimerin 1 3.98085
INPP1 inositol polyphosphate-1-phosphatase 3.90575
AARS1 alanyl-tRNA synthetase 1 3.9006
NMU neuromedin U 3.88975
CYCS cytochrome c, somatic 3.83245
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.3403
PYCR1 pyrroline-5-carboxylate reductase 1 3.2082
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.02965
EVL Enah/Vasp-like 2.9395
TXNRD1 thioredoxin reductase 1 2.8874
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.76113
PFDN2 prefoldin subunit 2 2.71965
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.71285
PHGDH phosphoglycerate dehydrogenase 2.7121
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.6867
GATA2 GATA binding protein 2 2.66423
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.61225
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.60685
YARS1 tyrosyl-tRNA synthetase 1 2.5802
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.5577
CDC45 cell division cycle 45 2.5517
MARS1 methionyl-tRNA synthetase 1 2.50905
GTPBP2 GTP binding protein 2 2.50885
DIPK1A divergent protein kinase domain 1A 2.48515
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.46735
CARS1 cysteinyl-tRNA synthetase 1 2.46502
ADGRG1 adhesion G protein-coupled receptor G1 2.45035
TSKU tsukushi, small leucine rich proteoglycan 2.4302
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.41665
ASL argininosuccinate lyase 2.36145
MRPL37 mitochondrial ribosomal protein L37 2.35955
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.35865
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.3534
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 2.35175
SARS1 seryl-tRNA synthetase 1 2.3499
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.33255
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.32155
ADAR adenosine deaminase, RNA-specific 2.3124
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.27992
BCHE butyrylcholinesterase 2.2793
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.2581
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.25755
DNM2 dynamin 2 2.25685
PDGFA platelet-derived growth factor alpha polypeptide 2.2531
UBE3C ubiquitin protein ligase E3C 2.2464
MAGEA6 melanoma antigen family A6 2.23472
CD8A CD8a molecule 2.2336
AKAP11 A kinase (PRKA) anchor protein 11 2.23275
AGK acylglycerol kinase 2.21983
RABEPK Rab9 effector protein with kelch motifs 2.2117
USP20 ubiquitin specific peptidase 20 2.1804
TARBP1 TAR (HIV-1) RNA binding protein 1 2.17485
MACF1 microtubule-actin crosslinking factor 1 2.14825
SLC75A1 solute carrier family 75 member 1 2.14365
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.14225
CDK19 cyclin-dependent kinase 19 2.13867
COG2 component of oligomeric golgi complex 2 2.12495
LOC128125814 uncharacterized LOC128125814 2.1195
CASC3 cancer susceptibility candidate 3 2.1094
USP36 ubiquitin specific peptidase 36 2.10765
FPGS folylpolyglutamate synthase 2.0953
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.0856
SYNGR3 synaptogyrin 3 2.0834
NDE1 nudE neurodevelopment protein 1 2.0735
CRCP CGRP receptor component 2.0734
SIDT1 SID1 transmembrane family, member 1 2.0496
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.04865
SCN3A sodium channel, voltage gated, type III alpha subunit 2.04695
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.02697
CYB5RL cytochrome b5 reductase-like 2.02615
CDK6 cyclin-dependent kinase 6 2.01925
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.00795
GGPS1 geranylgeranyl diphosphate synthase 1 2.0045
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.0005

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.4045
TCTN1 tectonic family member 1 -8.2429
CCNB2 cyclin B2 -7.61525
ACAA1 acetyl-CoA acyltransferase 1 -6.22075
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -5.7046
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -5.06565
TMEM97 transmembrane protein 97 -5.03679
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
ZNF586 zinc finger protein 586 -4.9814
SOAT2 sterol O-acyltransferase 2 -4.85803
ALDOC aldolase C, fructose-bisphosphate -4.7558
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.67595
AURKB aurora kinase B -4.31885
PGM1 phosphoglucomutase 1 -4.19605
HSPA1A heat shock 70kDa protein 1A -4.1113
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.87517
MAPK13 mitogen-activated protein kinase 13 -3.78872
GRWD1 glutamate-rich WD repeat containing 1 -3.7696
OXA1L oxidase (cytochrome c) assembly 1-like -3.76755
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.47462
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.41355
CHEK1 checkpoint kinase 1 -3.3214
KIF11 kinesin family member 11 -3.06565
MYOZ3 myozenin 3 -2.94885
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.8142
ISOC1 isochorismatase domain containing 1 -2.80455
RLN1 relaxin 1 -2.7998
DDB2 damage-specific DNA binding protein 2, 48kDa -2.7496
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.7448
AURKA aurora kinase A -2.73357
EBF2 early B-cell factor 2 -2.6354
CCNA2 cyclin A2 -2.5233
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.48248
KIF18A kinesin family member 18A -2.47905
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.46747
HMG20B high mobility group 20B -2.45843
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.45162
SPAG4 sperm associated antigen 4 -2.449
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.44635
HJURP Holliday junction recognition protein -2.42945
ZNF552 zinc finger protein 552 -2.42125
IQSEC3 IQ motif and Sec7 domain 3 -2.4166
PSRC1 proline/serine-rich coiled-coil 1 -2.4165
POLK polymerase (DNA directed) kappa -2.3996
CDC25B cell division cycle 25B -2.378
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.37145
ARMCX2 armadillo repeat containing, X-linked 2 -2.3678
DNAH7 dynein, axonemal, heavy chain 7 -2.35815
CLEC4E C-type lectin domain family 4, member E -2.35415
MIMS2 mitochondrial inner membrane scaffold 2 -2.3395
IFT46 intraflagellar transport 46 -2.33515
KCTD12 potassium channel tetramerization domain containing 12 -2.31645
CDC20 cell division cycle 20 -2.3163
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 -2.31455
ADI1 acireductone dioxygenase 1 -2.3127
CXCL6 chemokine (C-X-C motif) ligand 6 -2.3126
TM9SF2 transmembrane 9 superfamily member 2 -2.30455
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.28865
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.28045
ZNF211 zinc finger protein 211 -2.26515
KIF23 kinesin family member 23 -2.2633
FHL2 four and a half LIM domains 2 -2.2533
PANK2 pantothenate kinase 2 -2.25195
NUP85 nucleoporin 85kDa -2.2464
GDF15 growth differentiation factor 15 -2.24555
NASP nuclear autoantigenic sperm protein (histone-binding) -2.23927
VSTM4 V-set and transmembrane domain containing 4 -2.2383
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.23665
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.23085
NCF2 neutrophil cytosolic factor 2 -2.2254
NME5 NME/NM23 family member 5 -2.22425
SCD5 stearoyl-CoA desaturase 5 -2.21695
ZNF606 zinc finger protein 606 -2.19815
ELAC2 elaC ribonuclease Z 2 -2.19445
CHEK2 checkpoint kinase 2 -2.19397
TLR5 toll-like receptor 5 -2.18995
NUP62 nucleoporin 62kDa -2.18885
RNF39 ring finger protein 39 -2.1773
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -2.16637
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.1471
RBM22 RNA binding motif protein 22 -2.14485
PLK1 polo-like kinase 1 -2.12605
CDCA3 cell division cycle associated 3 -2.12565
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.12255
THAP11 THAP domain containing 11 -2.11915
PEX11A peroxisomal biogenesis factor 11 alpha -2.1061
TTC9 tetratricopeptide repeat domain 9 -2.1039
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.0999
MKI67 marker of proliferation Ki-67 -2.09457
COPZ1 coatomer protein complex, subunit zeta 1 -2.09175
RLN2 relaxin 2 -2.07695
RNF24 ring finger protein 24 -2.07172
ZNF304 zinc finger protein 304 -2.05935
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.0576
RAB36 RAB36, member RAS oncogene family -2.05305
DBR1 debranching RNA lariats 1 -2.03725
RBM47 RNA binding motif protein 47 -2.02315
DCPH1 damage control phosphatase 1 -2.01745
PTAFR platelet-activating factor receptor -2.01667
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.01115
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.00965
BAHD1 bromo adjacent homology domain containing 1 -2.00535
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.0015
NDN necdin, melanoma antigen (MAGE) family member -2.00085