CRCGN011_HEPG2_24H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN011_HEPG2_24H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
NOTCH1 notch 1 5.6368
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.13255
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 4.2497
DDIT4 DNA-damage-inducible transcript 4 4.22875
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.0071
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.95385
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.8418
DYNLT3 dynein, light chain, Tctex-type 3 3.8098
AMDHD2 amidohydrolase domain containing 2 3.44355
TRIB3 tribbles pseudokinase 3 3.44055
ADGRG1 adhesion G protein-coupled receptor G1 3.29635
RRAGA Ras-related GTP binding A 3.27795
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.08995
H2BC12 H2B clustered histone 12 3.08042
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.8781
TIAM1 T-cell lymphoma invasion and metastasis 1 2.87333
JADE2 jade family PHD finger 2 2.86427
NMU neuromedin U 2.8529
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.84145
ADGRE5 adhesion G protein-coupled receptor E5 2.7287
ISG15 ISG15 ubiquitin-like modifier 2.66055
GPER1 G protein-coupled estrogen receptor 1 2.66017
PMM2 phosphomannomutase 2 2.6213
XPOT exportin, tRNA 2.6164
IFI6 interferon, alpha-inducible protein 6 2.6049
CDH5 cadherin 5, type 2 (vascular endothelium) 2.603
IFI44L interferon-induced protein 44-like 2.56765
CHEK2 checkpoint kinase 2 2.56465
GARRE1 granule associated Rac and RHOG effector 1 2.5598
PLSCR3 phospholipid scramblase 3 2.54463
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.4673
SULT4A1 sulfotransferase family 4A, member 1 2.43715
USP18 ubiquitin specific peptidase 18 2.42195
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.4103
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.3439
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.32775
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.30692
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.29775
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.2939
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.2882
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.25605
PCDH12 protocadherin 12 2.22485
RIGI RNA sensor RIG-I 2.2184
RAI14 retinoic acid induced 14 2.218
TJP1 tight junction protein 1 2.20105
COPS5 COP9 signalosome subunit 5 2.19705
BAMBI BMP and activin membrane-bound inhibitor 2.1906
RSAD2 radical S-adenosyl methionine domain containing 2 2.1866
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 2.1321
KDR kinase insert domain receptor 2.1183
EFL1 elongation factor like GTPase 1 2.0756
CCP110 centriolar coiled coil protein 110kDa 2.0655
SARS1 seryl-tRNA synthetase 1 2.05075
FOXJ2 forkhead box J2 2.0425
SPRY4 sprouty homolog 4 (Drosophila) 2.03845
TBXA2R thromboxane A2 receptor 2.02785
PRAME preferentially expressed antigen in melanoma 2.02615
MX1 MX dynamin-like GTPase 1 2.0222
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.0207
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.0195
HABP2 hyaluronan binding protein 2 2.00515
TMEM204 transmembrane protein 204 2.00375

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
PCNA proliferating cell nuclear antigen -8.34975
KDM3A lysine (K)-specific demethylase 3A -6.0608
TCTN1 tectonic family member 1 -5.4741
TLCD3A TLC domain containing 3A -4.99255
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9098
UGDH UDP-glucose 6-dehydrogenase -4.5677
GRWD1 glutamate-rich WD repeat containing 1 -4.5196
ZMIZ1 zinc finger, MIZ-type containing 1 -3.8368
ADI1 acireductone dioxygenase 1 -3.41985
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.3855
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.20025
ALDOC aldolase C, fructose-bisphosphate -2.8466
IFRD2 interferon-related developmental regulator 2 -2.79857
KIF14 kinesin family member 14 -2.56685
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.5286
DCK deoxycytidine kinase -2.4488
PGAM4 phosphoglycerate mutase family member 4 -2.3968
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.31958
CCNB2 cyclin B2 -2.2679
FADS2 fatty acid desaturase 2 -2.2374
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.23548
ANKRD49 ankyrin repeat domain 49 -2.14725
HLA-DMA major histocompatibility complex, class II, DM alpha -2.14155
VILL villin-like -2.10905
LOC112694756 uncharaterized LOC112694756 -2.10258
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.0835
CTBS chitobiase, di-N-acetyl- -2.03522
MOB1A MOB kinase activator 1A -2.01585
SOAT2 sterol O-acyltransferase 2 -2.00615