CRCGN011_HEPG2_24H:O09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN011_HEPG2_24H:O09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 5.23933
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.9671
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.75675
NOTCH1 notch 1 4.73215
MAP7 microtubule-associated protein 7 4.68463
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.5391
SLC75A1 solute carrier family 75 member 1 4.5104
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.2747
CXCL2 chemokine (C-X-C motif) ligand 2 3.9772
PRKCH protein kinase C, eta 3.7879
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.7621
EPHB2 EPH receptor B2 3.5988
VAV3 vav 3 guanine nucleotide exchange factor 3.58183
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.28705
GPER1 G protein-coupled estrogen receptor 1 3.12287
MEST mesoderm specific transcript 3.11425
ZNF589 zinc finger protein 589 3.04357
JADE2 jade family PHD finger 2 3.0249
NOSIP nitric oxide synthase interacting protein 3.01975
ABHD6 abhydrolase domain containing 6 2.98407
MRPL12 mitochondrial ribosomal protein L12 2.62875
GRB10 growth factor receptor-bound protein 10 2.62762
DNASE1L3 deoxyribonuclease I-like 3 2.5971
IL22RA1 interleukin 22 receptor, alpha 1 2.51975
PCDH12 protocadherin 12 2.5175
CYB561 cytochrome b561 2.46142
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.4567
DSN1 DSN1, MIS12 kinetochore complex component 2.31315
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.2968
FOSL1 FOS-like antigen 1 2.29435
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.18132
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.17768
IFI44L interferon-induced protein 44-like 2.16945
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.14135
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.13985
BIRC2 baculoviral IAP repeat containing 2 2.13115
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.0844
RAB21 RAB21, member RAS oncogene family 2.08025
TMEM74B transmembrane protein 74B 2.07725
EDN1 endothelin 1 2.0661
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.02688
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.0218
SNX7 sorting nexin 7 2.0119
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.0046
ADGRG1 adhesion G protein-coupled receptor G1 2.0024

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
CCNB2 cyclin B2 -6.20355
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.17055
CHMP4B charged multivesicular body protein 4B -4.35835
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.26975
FBXL12 F-box and leucine-rich repeat protein 12 -3.91605
IFRD2 interferon-related developmental regulator 2 -3.85357
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.7458
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.36072
HMG20B high mobility group 20B -3.2541
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.11515
WASHC4 WASH complex subunit 4 -2.76308
OXA1L oxidase (cytochrome c) assembly 1-like -2.6785
MAPK13 mitogen-activated protein kinase 13 -2.5975
APOA2 apolipoprotein A-II -2.49815
VPREB1 pre-B lymphocyte 1 -2.4393
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.39847
CPM carboxypeptidase M -2.129
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -2.1208
GDAP2 ganglioside induced differentiation associated protein 2 -2.0739
MEIS2 Meis homeobox 2 -2.05315
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -2.04498
STX5 syntaxin 5 -2.0412
TMPRSS3 transmembrane protease, serine 3 -2.03985
GMPR guanosine monophosphate reductase -2.0359
RBM38 RNA binding motif protein 38 -2.02955
MSH6 mutS homolog 6 -2.02345
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.02245