CRCGN011_HEPG2_24H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.8939
CIAO3 cytosolic iron-sulfur assembly component 3 5.16085
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.785
SYNE2 spectrin repeat containing, nuclear envelope 2 4.7488
CYCS cytochrome c, somatic 3.85115
CRTAP cartilage associated protein 3.7982
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.4555
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.36465
WDTC1 WD and tetratricopeptide repeats 1 3.0876
SSBP2 single-stranded DNA binding protein 2 2.75137
TPST2 tyrosylprotein sulfotransferase 2 2.7384
TREM1 triggering receptor expressed on myeloid cells 1 2.638
TCEA2 transcription elongation factor A (SII), 2 2.5627
RAI14 retinoic acid induced 14 2.5494
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.30015
SHB Src homology 2 domain containing adaptor protein B 2.27807
TMEM109 transmembrane protein 109 2.2171
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.13333
BMP4 bone morphogenetic protein 4 2.12255
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.0941
CTSD cathepsin D 2.0565
COG7 component of oligomeric golgi complex 7 2.04585
NOSIP nitric oxide synthase interacting protein 2.03725
DUSP8 dual specificity phosphatase 8 2.02775

decreased expression

Symbol Name Standardized Value
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.3741
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.24925
UGDH UDP-glucose 6-dehydrogenase -5.1166
CCDC86 coiled-coil domain containing 86 -5.0039
VAT1 vesicle amine transport 1 -4.94775
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9417
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.66275
CDC20 cell division cycle 20 -4.66275
GDF15 growth differentiation factor 15 -4.6073
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.49032
MAP7 microtubule-associated protein 7 -4.4123
CCNB2 cyclin B2 -4.40985
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.80905
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.65315
OXA1L oxidase (cytochrome c) assembly 1-like -3.5742
GNAS GNAS complex locus -3.43215
HEATR1 HEAT repeat containing 1 -3.00035
VDAC1 voltage-dependent anion channel 1 -2.84198
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.7763
HLA-DMA major histocompatibility complex, class II, DM alpha -2.47295
PRPF4 pre-mRNA processing factor 4 -2.37742
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.3162
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.29135
PSRC1 proline/serine-rich coiled-coil 1 -2.28305
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.27155
TACC3 transforming, acidic coiled-coil containing protein 3 -2.20035
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.17668
HMG20B high mobility group 20B -2.12055
ASTN2 astrotactin 2 -2.07162
ABITRAM actin binding transcription modulator -2.0668
CD7 CD7 molecule -2.06677
NBPF3 neuroblastoma breakpoint family, member 3 -2.0428
CHIC2 cysteine-rich hydrophobic domain 2 -2.0259
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.0164
RNF4 ring finger protein 4 -2.0135
TMEM50A transmembrane protein 50A -2.0014