CRCGN011_HEPG2_24H:O11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

126 genes differentially expressed following the CRCGN011_HEPG2_24H:O11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
C2CD2 C2 calcium-dependent domain containing 2 6.23965
RXYLT1 ribitol xylosyltransferase 1 6.1576
INTS3 integrator complex subunit 3 5.33725
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.3003
BACE2 beta-site APP-cleaving enzyme 2 5.2587
MOK MOK protein kinase 5.09065
RPP38 ribonuclease P/MRP 38kDa subunit 5.08555
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.0671
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.0212
SYNE2 spectrin repeat containing, nuclear envelope 2 4.93495
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7319
TLR4 toll-like receptor 4 4.5335
VAV3 vav 3 guanine nucleotide exchange factor 4.49545
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.3057
SSBP2 single-stranded DNA binding protein 2 3.83407
PPIE peptidylprolyl isomerase E (cyclophilin E) 3.65825
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.64255
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.38995
COQ8A coenzyme Q8A 3.38115
TREM1 triggering receptor expressed on myeloid cells 1 3.2348
GPATCH8 G patch domain containing 8 3.19933
EVL Enah/Vasp-like 3.1526
JADE2 jade family PHD finger 2 2.9185
H2BC12 H2B clustered histone 12 2.87978
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.83813
FOSL1 FOS-like antigen 1 2.4658
CRELD2 cysteine-rich with EGF-like domains 2 2.45095
RHOH ras homolog family member H 2.438
F3 coagulation factor III (thromboplastin, tissue factor) 2.38005
CISH cytokine inducible SH2-containing protein 2.36785
MRPL48 mitochondrial ribosomal protein L48 2.344
PCDHB11 protocadherin beta 11 2.3233
MZB1 marginal zone B and B1 cell-specific protein 2.31345
MRPS31 mitochondrial ribosomal protein S31 2.31192
WIPF2 WAS/WASL interacting protein family, member 2 2.2955
VSTM4 V-set and transmembrane domain containing 4 2.2931
RIN2 Ras and Rab interactor 2 2.28315
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.26365
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.2398
BIRC2 baculoviral IAP repeat containing 2 2.20025
ZNF589 zinc finger protein 589 2.19662
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.1864
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.1548
UFM1 ubiquitin-fold modifier 1 2.11825
CISD1 CDGSH iron sulfur domain 1 2.10495
NID2 nidogen 2 (osteonidogen) 2.0875
COL11A1 collagen, type XI, alpha 1 2.08603
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.08563
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.0806
PTBP2 polypyrimidine tract binding protein 2 2.0371
EMP3 epithelial membrane protein 3 2.02995
GSTP1 glutathione S-transferase pi 1 2.02275
AEBP1 AE binding protein 1 2.0227
STAB1 stabilin 1 2.01585
TCL1B T-cell leukemia/lymphoma 1B 2.01455
CRYBG3 beta-gamma crystallin domain containing 3 2.01415

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.76985
TLCD3A TLC domain containing 3A -7.5131
GNAS GNAS complex locus -7.18751
HMG20B high mobility group 20B -6.759
NT5DC2 5'-nucleotidase domain containing 2 -5.77345
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.39555
MRPS2 mitochondrial ribosomal protein S2 -5.35085
CCDC86 coiled-coil domain containing 86 -5.0
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
KDM3A lysine (K)-specific demethylase 3A -4.78785
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.71875
THAP11 THAP domain containing 11 -4.5867
PECR peroxisomal trans-2-enoyl-CoA reductase -4.5463
CD58 CD58 molecule -4.36895
ITGB1BP1 integrin beta 1 binding protein 1 -3.91395
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.8788
CHMP4B charged multivesicular body protein 4B -3.7864
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.75665
CTSD cathepsin D -3.70055
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.4981
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.31023
ZMIZ1 zinc finger, MIZ-type containing 1 -3.29335
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.1994
IFRD2 interferon-related developmental regulator 2 -3.03883
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.977
NRIP1 nuclear receptor interacting protein 1 -2.85065
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.61013
SETD1A SET domain containing 1A -2.57075
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.5607
HOXB13 homeobox B13 -2.54035
CCNB2 cyclin B2 -2.5048
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.47445
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.41625
CD207 CD207 molecule, langerin -2.41225
NGRN neugrin, neurite outgrowth associated -2.4011
RCL1 RNA terminal phosphate cyclase-like 1 -2.3724
KCTD15 potassium channel tetramerization domain containing 15 -2.36515
CAPN15 calpain 15 -2.3541
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.33715
PEX10 peroxisomal biogenesis factor 10 -2.30763
CD320 CD320 molecule -2.3076
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -2.2738
VEGFB vascular endothelial growth factor B -2.27185
BCAM basal cell adhesion molecule (Lutheran blood group) -2.26942
USP25 ubiquitin specific peptidase 25 -2.24793
LYPD3 LY6/PLAUR domain containing 3 -2.2438
PCBP1 poly(rC) binding protein 1 -2.22065
CAMTA1 calmodulin binding transcription activator 1 -2.2045
OSMR oncostatin M receptor -2.19505
ATP9A ATPase, class II, type 9A -2.1935
ZSCAN16 zinc finger and SCAN domain containing 16 -2.1869
TROAP trophinin associated protein -2.1678
HOXD11 homeobox D11 -2.16225
LMO7 LIM domain 7 -2.15055
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -2.1209
KRT23 keratin 23, type I -2.10185
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.09745
ZNF556 zinc finger protein 556 -2.0971
MOSPD1 motile sperm domain containing 1 -2.09705
CCNH cyclin H -2.0943
TUSC2 tumor suppressor candidate 2 -2.06813
KCMF1 potassium channel modulatory factor 1 -2.05995
AVEN apoptosis, caspase activation inhibitor -2.03175
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.0284
NRGN neurogranin (protein kinase C substrate, RC3) -2.0274
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.01995
MEOX1 mesenchyme homeobox 1 -2.01565
LRP5 low density lipoprotein receptor-related protein 5 -2.0088
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.00145