CRCGN011_HEPG2_24H:O13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tributyl phosphate 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN011_HEPG2_24H:O13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 9.7508
CXCL2 chemokine (C-X-C motif) ligand 2 5.0372
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.1208
MINDY1 MINDY lysine 48 deubiquitinase 1 3.96305
GSTZ1 glutathione S-transferase zeta 1 3.4503
COL11A1 collagen, type XI, alpha 1 2.82085
KCTD5 potassium channel tetramerization domain containing 5 2.72025
TREM1 triggering receptor expressed on myeloid cells 1 2.67
GPATCH8 G patch domain containing 8 2.5394
SIRT3 sirtuin 3 2.45252
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.3917
PNKP polynucleotide kinase 3'-phosphatase 2.3764
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.26505
COLGALT1 collagen beta(1-O)galactosyltransferase 1 2.24985
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.21497
LIPT1 lipoyltransferase 1 2.1596
RIC8A RIC8 guanine nucleotide exchange factor A 2.1186
EMC2 ER membrane protein complex subunit 2 2.11845
BET1 Bet1 golgi vesicular membrane trafficking protein 2.1167
CXCL8 chemokine (C-X-C motif) ligand 8 2.09205
RAB5B RAB5B, member RAS oncogene family 2.0858
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.04965
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.03455
GAA glucosidase, alpha; acid 2.01875
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.0058

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.31705
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.1358
SMNDC1 survival motor neuron domain containing 1 -4.9612
ZNF586 zinc finger protein 586 -4.9384
PCNA proliferating cell nuclear antigen -4.82295
PUF60 poly-U binding splicing factor 60KDa -4.7809
DNM1L dynamin 1-like -4.67815
C2CD5 C2 calcium-dependent domain containing 5 -4.55355
MAP7 microtubule-associated protein 7 -4.50553
CDC25B cell division cycle 25B -4.1392
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.961
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.6055
FASTKD5 FAST kinase domains 5 -3.439
GRWD1 glutamate-rich WD repeat containing 1 -3.3056
SPAG4 sperm associated antigen 4 -3.1046
RAD51C RAD51 paralog C -2.97053
OXA1L oxidase (cytochrome c) assembly 1-like -2.9208
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.83638
ZNF134 zinc finger protein 134 -2.62735
SNX11 sorting nexin 11 -2.4844
ZNF180 zinc finger protein 180 -2.4624
ZNF274 zinc finger protein 274 -2.41255
HSPA2 heat shock 70kDa protein 2 -2.37755
TPPP3 tubulin polymerization-promoting protein family member 3 -2.33285
UBE3C ubiquitin protein ligase E3C -2.32695
EIF5 eukaryotic translation initiation factor 5 -2.31642
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.3082
ASPA aspartoacylase -2.27225
INTS13 integrator complex subunit 13 -2.23705
LPAR3 lysophosphatidic acid receptor 3 -2.1926
LY6G6C lymphocyte antigen 6 complex, locus G6C -2.17465
IPO8 importin 8 -2.1695
NRIP1 nuclear receptor interacting protein 1 -2.1669
SYNJ2BP synaptojanin 2 binding protein -2.1468
HLA-DMA major histocompatibility complex, class II, DM alpha -2.13225
CHURC1-FNTB CHURC1-FNTB readthrough -2.12892
AGTR1 angiotensin II receptor, type 1 -2.12558
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.10297
BICD1 bicaudal D homolog 1 (Drosophila) -2.09888
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.08625
ZNF551 zinc finger protein 551 -2.0759
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.0727
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.05885
RBMX RNA binding motif protein, X-linked -2.05395
FKBPL FK506 binding protein like -2.04895
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.03055
MAG myelin associated glycoprotein -2.0161
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.00105