CRCGN011_HEPG2_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tributyl phosphate 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN011_HEPG2_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.36455
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.03095
UBQLN2 ubiquilin 2 4.7644
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.75565
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.6172
STIMATE STIM activating enhancer 4.3968
CXCL2 chemokine (C-X-C motif) ligand 2 3.95805
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.8828
PFKL phosphofructokinase, liver 3.72152
MAP7 microtubule-associated protein 7 3.66815
CCL2 chemokine (C-C motif) ligand 2 3.4207
PRKCH protein kinase C, eta 3.40255
CBR3 carbonyl reductase 3 3.19095
BAMBI BMP and activin membrane-bound inhibitor 3.13365
COL11A1 collagen, type XI, alpha 1 2.54785
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.45125
MCM3 minichromosome maintenance complex component 3 2.3908
KLHL9 kelch-like family member 9 2.3724
ADAT1 adenosine deaminase, tRNA-specific 1 2.2644
HLA-DRA major histocompatibility complex, class II, DR alpha 2.21098
S100A1 S100 calcium binding protein A1 2.1986
GPATCH8 G patch domain containing 8 2.08345
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.04395
CCNF cyclin F 2.0267
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.01585
TULP4 tubby like protein 4 2.0131

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.53175
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.1533
FBXL12 F-box and leucine-rich repeat protein 12 -4.79845
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.744
GDF15 growth differentiation factor 15 -4.47675
VAT1 vesicle amine transport 1 -4.3249
CCNB2 cyclin B2 -3.8179
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.73165
RPS5 ribosomal protein S5 -3.6962
PCNA proliferating cell nuclear antigen -3.5712
GNAS GNAS complex locus -3.48675
ACAA1 acetyl-CoA acyltransferase 1 -3.40125
OXA1L oxidase (cytochrome c) assembly 1-like -3.22235
TCF12 transcription factor 12 -2.8253
TBCA tubulin folding cofactor A -2.5988
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.44428
ZNF623 zinc finger protein 623 -2.4186
AICDA activation-induced cytidine deaminase -2.23305
FGF7 fibroblast growth factor 7 -2.23215
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.2298
CCDC102B coiled-coil domain containing 102B -2.2155
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -2.1839
WASHC4 WASH complex subunit 4 -2.18275
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.15975
AQP9 aquaporin 9 -2.13415
TAS2R9 taste receptor, type 2, member 9 -2.1282
MAGEC3 melanoma antigen family C3 -2.12775
PF4V1 platelet factor 4 variant 1 -2.1002
PHB2 prohibitin 2 -2.091
WRNIP1 Werner helicase interacting protein 1 -2.0778
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.06848
ARHGAP12 Rho GTPase activating protein 12 -2.06345
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -2.05705
ACP3 acid phosphatase 3 -2.0481
SIRT4 sirtuin 4 -2.03135
FUCA1 fucosidase, alpha-L- 1, tissue -2.01875
OR7A10 olfactory receptor, family 7, subfamily A, member 10 -2.0035