CRCGN011_HEPG2_24H:O21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfafurazole 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN011_HEPG2_24H:O21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.7212
STK10 serine/threonine kinase 10 5.6531
PPARG peroxisome proliferator-activated receptor gamma 5.3203
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.0309
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.70215
CBR3 carbonyl reductase 3 3.923
GATA3 GATA binding protein 3 3.88467
TLR4 toll-like receptor 4 3.71035
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.686
GPER1 G protein-coupled estrogen receptor 1 3.29072
PRR15L proline rich 15-like 3.10805
SSBP2 single-stranded DNA binding protein 2 2.94318
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.6915
JADE2 jade family PHD finger 2 2.5002
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.40355
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.38285
DENR density-regulated protein 2.22555
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.1732
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.16735
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.11335
BIRC2 baculoviral IAP repeat containing 2 2.10355
CCNE2 cyclin E2 2.09835
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.0915
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.0715
SERF1A small EDRK-rich factor 1A (telomeric) 2.06435
SLC25A46 solute carrier family 25, member 46 2.0511
HACL2 2-hydroxyacyl-CoA lyase 2 2.04703
TWNK twinkle mtDNA helicase 2.02745
CCNF cyclin F 2.01105

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.1706
ZNF586 zinc finger protein 586 -6.69985
TUBB6 tubulin, beta 6 class V -5.0907
CDC20 cell division cycle 20 -4.66275
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.2852
GNAS GNAS complex locus -3.78501
ADI1 acireductone dioxygenase 1 -3.63575
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -3.07032
CHIC2 cysteine-rich hydrophobic domain 2 -2.9455
ZNF134 zinc finger protein 134 -2.9029
SLC35F2 solute carrier family 35, member F2 -2.77
NRIP1 nuclear receptor interacting protein 1 -2.6087
ZNF211 zinc finger protein 211 -2.5442
PRPF4 pre-mRNA processing factor 4 -2.53975
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.4232
ZNF419 zinc finger protein 419 -2.37035
IPO13 importin 13 -2.3369
PDZD2 PDZ domain containing 2 -2.30495
ZNF551 zinc finger protein 551 -2.2799
PRODH2 proline dehydrogenase (oxidase) 2 -2.2487
TOM1L2 target of myb1-like 2 (chicken) -2.24205
PTPRK protein tyrosine phosphatase, receptor type, K -2.2323
FZD8 frizzled class receptor 8 -2.2086
ZNF93 zinc finger protein 93 -2.19653
IL36R interleukin 36 receptor -2.17395
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -2.17295
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.1565
ZNF548 zinc finger protein 548 -2.1316
EDN2 endothelin 2 -2.11605
PCDHGA3 protocadherin gamma subfamily A, 3 -2.08545
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.08297
ZNF532 zinc finger protein 532 -2.07065
CD1C CD1c molecule -2.06765
ZNF304 zinc finger protein 304 -2.0504
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.04885
ACAA1 acetyl-CoA acyltransferase 1 -2.04798
ROGDI rogdi homolog (Drosophila) -2.03645
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.0313