CRCGN011_HEPG2_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfafurazole 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN011_HEPG2_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPATCH8 G patch domain containing 8 5.86863
ADRB2 adrenoceptor beta 2, surface 5.7061
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.6305
CHMP6 charged multivesicular body protein 6 5.2424
MYLK myosin light chain kinase 5.0776
BZW2 basic leucine zipper and W2 domains 2 4.95955
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.7297
PPARG peroxisome proliferator-activated receptor gamma 4.39275
STIMATE STIM activating enhancer 4.34255
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.2268
SATB1 SATB homeobox 1 4.1974
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.03662
FGFR4 fibroblast growth factor receptor 4 4.02458
CXCL2 chemokine (C-X-C motif) ligand 2 3.95805
IDE insulin-degrading enzyme 3.84812
TLR4 toll-like receptor 4 3.79445
TIAM1 T-cell lymphoma invasion and metastasis 1 3.72187
BIRC2 baculoviral IAP repeat containing 2 3.6711
VGLL4 vestigial-like family member 4 3.27995
CHEK2 checkpoint kinase 2 2.87258
ADAT1 adenosine deaminase, tRNA-specific 1 2.8613
EPN2 epsin 2 2.84643
SKIC2 SKI2 subunit of superkiller complex 2.7573
ATP11B ATPase, class VI, type 11B 2.71295
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.6841
MARCHF3 membrane associated ring-CH-type finger 3 2.676
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.65065
CREB1 cAMP responsive element binding protein 1 2.6059
IRF2 interferon regulatory factor 2 2.5795
DLK1 delta-like 1 homolog (Drosophila) 2.57145
S100PBP S100P binding protein 2.55465
CTSL cathepsin L 2.4844
GRB10 growth factor receptor-bound protein 10 2.47427
ARGLU1 arginine and glutamate rich 1 2.4739
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.47
MYO18A myosin XVIIIA 2.4335
EVL Enah/Vasp-like 2.42895
SLC38A6 solute carrier family 38, member 6 2.41495
JADE2 jade family PHD finger 2 2.38963
HMOX1 heme oxygenase 1 2.32455
TSKU tsukushi, small leucine rich proteoglycan 2.253
CYCS cytochrome c, somatic 2.22935
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 2.21992
AP4M1 adaptor-related protein complex 4, mu 1 subunit 2.216
EREG epiregulin 2.21555
SELE selectin E 2.206
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.2055
NCBP3 nuclear cap binding subunit 3 2.2018
CCNF cyclin F 2.19625
COQ8A coenzyme Q8A 2.1951
XPO4 exportin 4 2.19235
ABT1 activator of basal transcription 1 2.181
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.17265
RLF rearranged L-myc fusion 2.1723
PIPOX pipecolic acid oxidase 2.1585
BRD4 bromodomain containing 4 2.15083
TRIM16 tripartite motif containing 16 2.1478
TESK2 testis-specific kinase 2 2.14655
BMP6 bone morphogenetic protein 6 2.13985
PEG3 paternally expressed 3 2.1386
NUP133 nucleoporin 133kDa 2.13795
KAT7 K(lysine) acetyltransferase 7 2.10375
LGALSL lectin, galactoside-binding-like 2.1023
ZNF589 zinc finger protein 589 2.09295
DRC9 dynein regulatory complex subunit 9 2.08735
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.08195
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.0799
VCAM1 vascular cell adhesion molecule 1 2.07925
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 2.05915
CRYL1 crystallin, lambda 1 2.05605
SCARA3 scavenger receptor class A, member 3 2.05535
CXCL3 chemokine (C-X-C motif) ligand 3 2.041
CD163L1 CD163 molecule-like 1 2.0409
FBXO11 F-box protein 11 2.0353
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.02855
TMEM38B transmembrane protein 38B 2.0218

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.85087
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.11195
HMG20B high mobility group 20B -4.96835
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.92775
TSPAN4 tetraspanin 4 -4.7185
LDHD lactate dehydrogenase D -4.7071
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.66275
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.18565
CCNB2 cyclin B2 -3.6495
DERA deoxyribose-phosphate aldolase (putative) -3.3192
LYPLA1 lysophospholipase I -3.05437
NVL nuclear VCP-like -3.0129
ADI1 acireductone dioxygenase 1 -3.0085
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.99288
GRN granulin -2.93297
ITGB1BP1 integrin beta 1 binding protein 1 -2.73822
CDC25B cell division cycle 25B -2.63365
RGS2 regulator of G-protein signaling 2 -2.5637
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.52245
TBCB tubulin folding cofactor B -2.47132
CXCL14 chemokine (C-X-C motif) ligand 14 -2.4542
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.4481
SP140 SP140 nuclear body protein -2.4336
HLA-DMB major histocompatibility complex, class II, DM beta -2.4291
PDCD5 programmed cell death 5 -2.4205
HRAS Harvey rat sarcoma viral oncogene homolog -2.3588
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.3499
MAP2K1 mitogen-activated protein kinase kinase 1 -2.28085
TLCD3A TLC domain containing 3A -2.26605
CHEK1 checkpoint kinase 1 -2.24255
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.23263
PTPRK protein tyrosine phosphatase, receptor type, K -2.16045
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.14243
CDH22 cadherin 22, type 2 -2.14145
RBM42 RNA binding motif protein 42 -2.1058
TMEM147 transmembrane protein 147 -2.1055
HLA-DMA major histocompatibility complex, class II, DM alpha -2.09575
MRPL15 mitochondrial ribosomal protein L15 -2.09535
STAP1 signal transducing adaptor family member 1 -2.09085
PCDHA10 protocadherin alpha 10 -2.0744
IFT140 intraflagellar transport 140 -2.06315
PSENEN presenilin enhancer gamma secretase subunit -2.0441
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.04338
UBA2 ubiquitin-like modifier activating enzyme 2 -2.04215
FAM50A family with sequence similarity 50, member A -2.03345
HAO2 hydroxyacid oxidase 2 (long chain) -2.0239