CRCGN011_HEPG2_24H:O24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfafurazole 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN011_HEPG2_24H:O24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.69875
SYNE2 spectrin repeat containing, nuclear envelope 2 5.0112
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.70735
STK10 serine/threonine kinase 10 4.31528
LOC122526780 uncharacterized LOC122526780 3.67505
LCN2 lipocalin 2 3.56335
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.4083
SSBP2 single-stranded DNA binding protein 2 3.39938
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.7184
WDTC1 WD and tetratricopeptide repeats 1 2.56487
ADAT1 adenosine deaminase, tRNA-specific 1 2.54835
STX1A syntaxin 1A (brain) 2.3979
RNF167 ring finger protein 167 2.39675
CALU calumenin 2.3842
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.27935
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.2008
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.0395
TIPIN TIMELESS interacting protein 2.0063

decreased expression

Symbol Name Standardized Value
PGAM4 phosphoglycerate mutase family member 4 -4.88795
LDHD lactate dehydrogenase D -4.85965
DNM1L dynamin 1-like -4.6911
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.68205
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.47835
EIF5 eukaryotic translation initiation factor 5 -4.25556
THAP11 THAP domain containing 11 -4.1472
DDIT4 DNA-damage-inducible transcript 4 -3.96825
USP6NL USP6 N-terminal like -3.8328
GNAS GNAS complex locus -3.77372
ZMIZ1 zinc finger, MIZ-type containing 1 -3.68135
OXA1L oxidase (cytochrome c) assembly 1-like -3.6681
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.5173
CGRRF1 cell growth regulator with ring finger domain 1 -3.4405
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.30595
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.15185
TCERG1 transcription elongation regulator 1 -2.81365
ENO1 enolase 1, (alpha) -2.57863
ACVR2A activin A receptor, type IIA -2.4492
RBM34 RNA binding motif protein 34 -2.38578
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.3793
TRIM5 tripartite motif containing 5 -2.3067
NRIP1 nuclear receptor interacting protein 1 -2.298
CILK1 ciliogenesis associated kinase 1 -2.17205
CLCA4 chloride channel accessory 4 -2.15755
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) -2.14887
GJA9 gap junction protein, alpha 9, 59kDa -2.14085
PSRC1 proline/serine-rich coiled-coil 1 -2.10425
H2AJ H2A.J histone -2.0772
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -2.07195
CPNE3 copine III -2.0285
CCNC cyclin C -2.0049