CRCGN011_HEPG2_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroepiandrosterone 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

245 genes differentially expressed following the CRCGN011_HEPG2_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 10.0
ALDOC aldolase C, fructose-bisphosphate 6.5005
CARMIL1 capping protein regulator and myosin 1 linker 1 5.6708
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.3997
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.2567
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 5.1911
ADRB2 adrenoceptor beta 2, surface 4.94835
SATB1 SATB homeobox 1 4.6629
MAP7 microtubule-associated protein 7 4.53542
TLR4 toll-like receptor 4 4.36765
RPP38 ribonuclease P/MRP 38kDa subunit 4.3563
PLS1 plastin 1 4.351
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.2442
GPER1 G protein-coupled estrogen receptor 1 4.13562
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 3.97035
DENND2D DENN/MADD domain containing 2D 3.9216
ABHD6 abhydrolase domain containing 6 3.87738
PEX11A peroxisomal biogenesis factor 11 alpha 3.6801
KDM5A lysine (K)-specific demethylase 5A 3.65875
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.58693
UBQLN2 ubiquilin 2 3.5076
ANKRD10 ankyrin repeat domain 10 3.50035
CCL2 chemokine (C-C motif) ligand 2 3.30305
CELF2 CUGBP, Elav-like family member 2 3.21055
NNT nicotinamide nucleotide transhydrogenase 3.1922
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.1907
ABHD4 abhydrolase domain containing 4 3.1783
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.1565
BAD BCL2-associated agonist of cell death 3.1448
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.11165
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.00658
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.9798
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.9539
CREG1 cellular repressor of E1A-stimulated genes 1 2.89505
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.8885
BAMBI BMP and activin membrane-bound inhibitor 2.8857
MBNL2 muscleblind-like splicing regulator 2 2.87645
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.83915
IRF8 interferon regulatory factor 8 2.7569
PYCR1 pyrroline-5-carboxylate reductase 1 2.7555
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.75145
HAVCR1 hepatitis A virus cellular receptor 1 2.74335
WASF3 WAS protein family, member 3 2.72765
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.6954
DUSP14 dual specificity phosphatase 14 2.68235
RALB v-ral simian leukemia viral oncogene homolog B 2.67832
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.56735
CASZ1 castor zinc finger 1 2.55615
PPME1 protein phosphatase methylesterase 1 2.55305
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.538
STXBP1 syntaxin binding protein 1 2.5231
FASTKD5 FAST kinase domains 5 2.52215
ZNF692 zinc finger protein 692 2.51165
NT5DC2 5'-nucleotidase domain containing 2 2.45455
TSKU tsukushi, small leucine rich proteoglycan 2.44535
SNX7 sorting nexin 7 2.4356
DHDDS dehydrodolichyl diphosphate synthase 2.38975
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.38525
IL1A interleukin 1, alpha 2.37675
NTN3 netrin 3 2.3668
ZNF318 zinc finger protein 318 2.36615
COL11A1 collagen, type XI, alpha 1 2.34773
SLC75A1 solute carrier family 75 member 1 2.3385
TRIM9 tripartite motif containing 9 2.3358
TRAF1 TNF receptor-associated factor 1 2.33555
SNRPN small nuclear ribonucleoprotein polypeptide N 2.3293
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.32435
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.31805
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.303
HMOX1 heme oxygenase 1 2.28335
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.2824
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.28205
MINDY1 MINDY lysine 48 deubiquitinase 1 2.2766
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.27437
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.27425
MFN2 mitofusin 2 2.26338
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.2555
PRKCD protein kinase C, delta 2.255
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.25365
PAAF1 proteasomal ATPase-associated factor 1 2.24765
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.2441
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.23225
CCDC86 coiled-coil domain containing 86 2.22135
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.22062
MEOX2 mesenchyme homeobox 2 2.2182
IL3RA interleukin 3 receptor, alpha (low affinity) 2.21605
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.21285
HSPA14 heat shock 70kDa protein 14 2.21235
ARFIP2 ADP-ribosylation factor interacting protein 2 2.2119
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.20605
GK glycerol kinase 2.19951
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.19865
SKIC3 SKI3 subunit of superkiller complex 2.19418
CDK7 cyclin-dependent kinase 7 2.19385
SH3D19 SH3 domain containing 19 2.18625
FCHO1 FCH domain only 1 2.18195
MFAP4 microfibrillar-associated protein 4 2.18085
PGM1 phosphoglucomutase 1 2.1638
CCP110 centriolar coiled coil protein 110kDa 2.14375
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.14145
CLN3 ceroid-lipofuscinosis, neuronal 3 2.1357
ADORA2A adenosine A2a receptor 2.13425
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.12745
PTHLH parathyroid hormone-like hormone 2.10553
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.1044
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.0983
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.0907
EVL Enah/Vasp-like 2.0907
ACADVL acyl-CoA dehydrogenase, very long chain 2.08055
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.07885
STOM stomatin 2.07775
EML3 echinoderm microtubule associated protein like 3 2.073
ABI3BP ABI family, member 3 (NESH) binding protein 2.0717
TOM1 target of myb1 (chicken) 2.06855
LRRC31 leucine rich repeat containing 31 2.0685
PMP2 peripheral myelin protein 2 2.0677
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.064
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.0573
CCNF cyclin F 2.05665
SLC66A2 solute carrier family 66 member 2 2.0546
FGFBP1 fibroblast growth factor binding protein 1 2.0455
TSLIG3A tRNA splicing ligase complex subunit 3A 2.03445
PRPF31 pre-mRNA processing factor 31 2.02813
TULP4 tubby like protein 4 2.02385
DMD dystrophin 2.01988
LOC124907782 dual specificity protein phosphatase 22 2.01535
SPAG7 sperm associated antigen 7 2.0152
IL11RA interleukin 11 receptor, alpha 2.01425
HMGB3 high mobility group box 3 2.0139
MACIR macrophage immunometabolism regulator 2.00795

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.69755
VAT1 vesicle amine transport 1 -6.0688
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.74165
TM9SF3 transmembrane 9 superfamily member 3 -5.15945
ZW10 zw10 kinetochore protein -4.8661
GDF15 growth differentiation factor 15 -4.8093
PCNA proliferating cell nuclear antigen -4.7455
NGRN neugrin, neurite outgrowth associated -4.72525
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.59635
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.26475
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.26305
CCNB2 cyclin B2 -3.75435
TOR1A torsin family 1, member A (torsin A) -3.7249
TM9SF2 transmembrane 9 superfamily member 2 -3.6755
SQOR sulfide quinone oxidoreductase -3.55995
GNAS GNAS complex locus -3.4532
SPAG4 sperm associated antigen 4 -3.41825
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.3716
PRCP prolylcarboxypeptidase (angiotensinase C) -3.2927
TUBB6 tubulin, beta 6 class V -3.29085
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -3.23755
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -3.21595
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.16495
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.15815
NTAQ1 N-terminal glutamine amidase 1 -3.1323
SCAND1 SCAN domain containing 1 -3.08295
PECR peroxisomal trans-2-enoyl-CoA reductase -3.02345
HAT1 histone acetyltransferase 1 -3.0093
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.99745
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.97665
MYL12B myosin, light chain 12B, regulatory -2.9732
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.9114
KIF14 kinesin family member 14 -2.8682
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -2.86465
RGS2 regulator of G-protein signaling 2 -2.81765
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.80595
WASHC4 WASH complex subunit 4 -2.79687
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.7954
CIRBP cold inducible RNA binding protein -2.7924
HDAC1 histone deacetylase 1 -2.7896
FAIM Fas apoptotic inhibitory molecule -2.76
CAB39 calcium binding protein 39 -2.73655
IER3 immediate early response 3 -2.67775
TBC1D31 TBC1 domain family, member 31 -2.6535
ANXA7 annexin A7 -2.6219
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.58445
GMFG glia maturation factor, gamma -2.5581
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.542
NCK2 NCK adaptor protein 2 -2.4878
BZW2 basic leucine zipper and W2 domains 2 -2.48495
STN1 STN1 subunit of CST complex -2.4839
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.4749
KDM3A lysine (K)-specific demethylase 3A -2.4706
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -2.46065
TCTN1 tectonic family member 1 -2.46015
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.4453
TCEAL4 transcription elongation factor A (SII)-like 4 -2.4449
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.43535
TEX10 testis expressed 10 -2.4141
HYAL2 hyaluronoglucosaminidase 2 -2.4098
CLEC11A C-type lectin domain family 11, member A -2.4082
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.3991
TMSB15B thymosin beta 15B -2.39585
SNX11 sorting nexin 11 -2.34387
NGFR nerve growth factor receptor -2.34315
STK16 serine/threonine kinase 16 -2.34195
UBE2C ubiquitin-conjugating enzyme E2C -2.32815
WASHC3 WASH complex subunit 3 -2.31995
NPTX2 neuronal pentraxin II -2.3042
RAB21 RAB21, member RAS oncogene family -2.28415
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.28365
SOCS2 suppressor of cytokine signaling 2 -2.27763
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.26265
SMNDC1 survival motor neuron domain containing 1 -2.2502
DYNLT3 dynein, light chain, Tctex-type 3 -2.2436
JUP junction plakoglobin -2.2388
COA3 cytochrome c oxidase assembly factor 3 -2.2366
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.20865
GTPBP8 GTP-binding protein 8 (putative) -2.20595
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.2028
ZDHHC13 zinc finger, DHHC-type containing 13 -2.201
CDC7 cell division cycle 7 -2.19685
PTMA prothymosin, alpha -2.19233
ENOPH1 enolase-phosphatase 1 -2.1876
ADGRG2 adhesion G protein-coupled receptor G2 -2.17995
CD200 CD200 molecule -2.17913
MUC16 mucin 16, cell surface associated -2.17085
CHIC2 cysteine-rich hydrophobic domain 2 -2.1622
NUP93 nucleoporin 93kDa -2.1378
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.1339
ELAC2 elaC ribonuclease Z 2 -2.1317
PGLS 6-phosphogluconolactonase -2.12407
BBLN bublin coiled coil protein -2.11908
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.11585
BCAS3 breast carcinoma amplified sequence 3 -2.1134
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.1125
DYNLRB1 dynein, light chain, roadblock-type 1 -2.10442
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.08325
MYL9 myosin, light chain 9, regulatory -2.0693
KIFC1 kinesin family member C1 -2.0619
BTBD1 BTB (POZ) domain containing 1 -2.05775
HDAC2 histone deacetylase 2 -2.05745
NPM3 nucleophosmin/nucleoplasmin 3 -2.05695
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -2.05605
RNASE7 ribonuclease, RNase A family, 7 -2.05408
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.05035
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.04945
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.0349
DSCC1 DNA replication and sister chromatid cohesion 1 -2.03135
TRIM39-RPP21 TRIM39-RPP21 readthrough -2.02715
TXLNA taxilin alpha -2.0182
TBC1D15 TBC1 domain family, member 15 -2.01305
FZD10 frizzled class receptor 10 -2.01275
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.00425
DUSP6 dual specificity phosphatase 6 -2.0019