CRCGN011_HEPG2_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroepiandrosterone 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

192 genes differentially expressed following the CRCGN011_HEPG2_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 10.0
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
PRKCD protein kinase C, delta 6.3166
TBPL1 TBP-like 1 5.71255
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.5249
PLS1 plastin 1 5.43455
MINDY1 MINDY lysine 48 deubiquitinase 1 4.9937
CBR3 carbonyl reductase 3 4.66275
PPARG peroxisome proliferator-activated receptor gamma 4.6509
NOTCH1 notch 1 4.5848
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.48835
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 4.3854
TESK1 testis-specific kinase 1 4.21175
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 4.1261
GPER1 G protein-coupled estrogen receptor 1 4.06843
NSDHL NAD(P) dependent steroid dehydrogenase-like 4.01178
MCM3 minichromosome maintenance complex component 3 3.90765
ADGRE5 adhesion G protein-coupled receptor E5 3.7726
ALDOC aldolase C, fructose-bisphosphate 3.6253
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.3591
EVL Enah/Vasp-like 3.3509
ZDHHC6 zinc finger, DHHC-type containing 6 3.34005
TSKU tsukushi, small leucine rich proteoglycan 3.2794
SLC75A1 solute carrier family 75 member 1 3.2571
MEST mesoderm specific transcript 3.24215
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.99285
ABHD4 abhydrolase domain containing 4 2.9756
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.8245
ANKRD10 ankyrin repeat domain 10 2.79225
KLHL9 kelch-like family member 9 2.75935
FASTKD5 FAST kinase domains 5 2.72655
SSBP2 single-stranded DNA binding protein 2 2.69023
NNT nicotinamide nucleotide transhydrogenase 2.65352
PMM2 phosphomannomutase 2 2.63485
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.6343
EPN2 epsin 2 2.63345
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.6204
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.5817
GCLC glutamate-cysteine ligase, catalytic subunit 2.5257
STK25 serine/threonine kinase 25 2.4975
BAD BCL2-associated agonist of cell death 2.48915
SATB1 SATB homeobox 1 2.48915
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.4858
COL11A1 collagen, type XI, alpha 1 2.44392
FBXO3 F-box protein 3 2.43605
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.43335
DIPK1A divergent protein kinase domain 1A 2.42815
DUSP14 dual specificity phosphatase 14 2.4222
AMDHD2 amidohydrolase domain containing 2 2.4094
HMOX1 heme oxygenase 1 2.40745
SLC25A44 solute carrier family 25, member 44 2.40703
FAM193B family with sequence similarity 193, member B 2.37205
CRTAM cytotoxic and regulatory T cell molecule 2.3547
JADE2 jade family PHD finger 2 2.3544
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.3464
SPAG7 sperm associated antigen 7 2.3422
GATA2 GATA binding protein 2 2.33165
UBE3C ubiquitin protein ligase E3C 2.3039
CCS copper chaperone for superoxide dismutase 2.2874
WDR7 WD repeat domain 7 2.2588
CENPX centromere protein X 2.25305
MAN2B1 mannosidase, alpha, class 2B, member 1 2.24017
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.2206
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 2.21025
COMMD3 COMM domain containing 3 2.18325
CTSL cathepsin L 2.1741
PDZRN4 PDZ domain containing ring finger 4 2.1679
CCNF cyclin F 2.16613
CTSW cathepsin W 2.16225
HMG20B high mobility group 20B 2.14422
FN3KRP fructosamine 3 kinase related protein 2.1266
DHPS deoxyhypusine synthase 2.1139
MACIR macrophage immunometabolism regulator 2.10005
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.09505
ZDHHC18 zinc finger, DHHC-type containing 18 2.09135
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.0812
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.07735
GSTA4 glutathione S-transferase alpha 4 2.07395
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.0666
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0555
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.05452
BLVRB biliverdin reductase B 2.02965
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.02955
ECI1 enoyl-CoA delta isomerase 1 2.0226
NUPR1 nuclear protein, transcriptional regulator, 1 2.01555
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.0051
MCOLN1 mucolipin 1 2.0048
PGRMC1 progesterone receptor membrane component 1 2.00098
ZNF589 zinc finger protein 589 2.00055

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -8.75185
GNAS GNAS complex locus -7.27616
NT5DC2 5'-nucleotidase domain containing 2 -5.161
LDHD lactate dehydrogenase D -4.89775
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.77185
CIRBP cold inducible RNA binding protein -4.57065
DSG2 desmoglein 2 -4.55255
TRIB3 tribbles pseudokinase 3 -4.52715
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.48755
SMNDC1 survival motor neuron domain containing 1 -4.4723
NGRN neugrin, neurite outgrowth associated -4.29865
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.28755
CCDC86 coiled-coil domain containing 86 -4.27655
RPIA ribose 5-phosphate isomerase A -4.25085
CCNB2 cyclin B2 -3.95735
SPAG4 sperm associated antigen 4 -3.7889
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.7116
HEATR1 HEAT repeat containing 1 -3.34678
SCAND1 SCAN domain containing 1 -3.34335
GRWD1 glutamate-rich WD repeat containing 1 -3.3012
MTFR1 mitochondrial fission regulator 1 -3.2824
WASHC4 WASH complex subunit 4 -3.26933
TM9SF2 transmembrane 9 superfamily member 2 -3.2069
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.02672
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.0188
PECR peroxisomal trans-2-enoyl-CoA reductase -3.01575
ZMIZ1 zinc finger, MIZ-type containing 1 -3.00385
ACAA1 acetyl-CoA acyltransferase 1 -2.8995
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.85565
ZW10 zw10 kinetochore protein -2.8481
TOMM34 translocase of outer mitochondrial membrane 34 -2.8365
KIF14 kinesin family member 14 -2.81455
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.78105
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.77365
PRPF4 pre-mRNA processing factor 4 -2.72837
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.7046
FAIM Fas apoptotic inhibitory molecule -2.66485
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.6587
UBE4A ubiquitination factor E4A -2.64635
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.64622
SMYD5 SMYD family member 5 -2.6284
CAB39 calcium binding protein 39 -2.57025
RBKS ribokinase -2.568
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.55695
PDE8A phosphodiesterase 8A -2.5517
RNASE7 ribonuclease, RNase A family, 7 -2.53945
CLTCL1 clathrin, heavy chain-like 1 -2.51495
AURKB aurora kinase B -2.5097
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.48375
SCG5 secretogranin V -2.4509
HAT1 histone acetyltransferase 1 -2.43935
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.42455
GSTZ1 glutathione S-transferase zeta 1 -2.38085
GOLT1B golgi transport 1B -2.3689
LRRC41 leucine rich repeat containing 41 -2.36815
RAB21 RAB21, member RAS oncogene family -2.35
LARP6 La ribonucleoprotein domain family, member 6 -2.34595
CHEK1 checkpoint kinase 1 -2.31792
BZW2 basic leucine zipper and W2 domains 2 -2.31475
TM9SF3 transmembrane 9 superfamily member 3 -2.30155
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.29295
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.27507
UBE2C ubiquitin-conjugating enzyme E2C -2.2748
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.27
PCNP PEST proteolytic signal containing nuclear protein -2.25465
EIF5 eukaryotic translation initiation factor 5 -2.25104
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.22425
KLK1 kallikrein 1 -2.2172
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.2034
ELAC2 elaC ribonuclease Z 2 -2.1913
PRCP prolylcarboxypeptidase (angiotensinase C) -2.1894
DYNLT3 dynein, light chain, Tctex-type 3 -2.1736
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.15965
ADD3 adducin 3 (gamma) -2.1576
TRAIP TRAF interacting protein -2.15075
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.1505
KRABD4 KRAB domain containing 4 -2.1487
CPVL carboxypeptidase, vitellogenic-like -2.14595
MRPS15 mitochondrial ribosomal protein S15 -2.1406
DNAAF5 dynein, axonemal, assembly factor 5 -2.1331
MRPS16 mitochondrial ribosomal protein S16 -2.1249
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.1107
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.10315
SRRD SRR1 domain containing -2.0989
AHCY adenosylhomocysteinase -2.09225
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.07815
SIK2 salt-inducible kinase 2 -2.07595
RPN2 ribophorin II -2.06707
C2CD2 C2 calcium-dependent domain containing 2 -2.0566
GID4 GID complex subunit 4 -2.0559
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.05585
RNF25 ring finger protein 25 -2.05235
ACTMAP actin maturation protease -2.04735
CORT cortistatin -2.04655
TMEM209 transmembrane protein 209 -2.04545
MIS18A MIS18 kinetochore protein A -2.03145
TG thyroglobulin -2.0263
PEDS1 plasmanylethanolamine desaturase 1 -2.01945
HLA-DMA major histocompatibility complex, class II, DM alpha -2.01815
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.01465
KLHL7 kelch-like family member 7 -2.00907
RPL26L1 ribosomal protein L26-like 1 -2.0043
ASB9 ankyrin repeat and SOCS box containing 9 -2.0016