CRCGN011_HEPG2_24H:P05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dehydroepiandrosterone 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

233 genes differentially expressed following the CRCGN011_HEPG2_24H:P05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.82375
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.3304
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.22762
PLS1 plastin 1 5.1006
ANO1 anoctamin 1, calcium activated chloride channel 5.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.8973
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7461
LAGE3 L antigen family, member 3 4.5797
PRAF2 PRA1 domain family, member 2 4.5515
MAP3K4 mitogen-activated protein kinase kinase kinase 4 4.2933
SLC75A1 solute carrier family 75 member 1 4.2539
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.14975
NMU neuromedin U 4.0059
TESK1 testis-specific kinase 1 3.85375
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.80218
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.7791
CARMIL1 capping protein regulator and myosin 1 linker 1 3.5921
MEST mesoderm specific transcript 3.5879
WDR7 WD repeat domain 7 3.55105
GPER1 G protein-coupled estrogen receptor 1 3.54072
UBE2A ubiquitin-conjugating enzyme E2A 3.44335
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.41625
GATA3 GATA binding protein 3 3.18342
LSR lipolysis stimulated lipoprotein receptor 3.10775
CORO1A coronin, actin binding protein, 1A 3.09805
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.0853
SIRT3 sirtuin 3 3.07133
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 3.0389
IDE insulin-degrading enzyme 2.98488
HBEGF heparin-binding EGF-like growth factor 2.95918
ZDHHC6 zinc finger, DHHC-type containing 6 2.9139
RRAGA Ras-related GTP binding A 2.8955
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.8511
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.79635
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.77988
ALDOC aldolase C, fructose-bisphosphate 2.77435
GARRE1 granule associated Rac and RHOG effector 1 2.76195
RANBP2 RAN binding protein 2 2.76008
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.7271
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.72598
KCTD5 potassium channel tetramerization domain containing 5 2.6838
SNCAIP synuclein, alpha interacting protein 2.59
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.57985
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 2.57765
FAT2 FAT atypical cadherin 2 2.57065
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.56455
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.56005
SSBP2 single-stranded DNA binding protein 2 2.53783
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.53395
TLK2 tousled-like kinase 2 2.5227
CHAD chondroadherin 2.52195
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.49445
DENND2B DENN domain containing 2B 2.47705
WDR19 WD repeat domain 19 2.43255
TRAPPC3 trafficking protein particle complex 3 2.43088
TPD52L2 tumor protein D52-like 2 2.4157
RIC8A RIC8 guanine nucleotide exchange factor A 2.40315
SLN sarcolipin 2.39895
NISCH nischarin 2.39345
MCOLN1 mucolipin 1 2.38425
CD151 CD151 molecule (Raph blood group) 2.3718
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.36135
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.33008
CCDC86 coiled-coil domain containing 86 2.31875
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.3162
TBXA2R thromboxane A2 receptor 2.30713
PON2 paraoxonase 2 2.30603
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.29838
CDK7 cyclin-dependent kinase 7 2.2917
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2.2886
EPS8L2 EPS8-like 2 2.2822
TSKU tsukushi, small leucine rich proteoglycan 2.2796
GSTA3 glutathione S-transferase alpha 3 2.27245
GRAMD2B GRAM domain containing 2B 2.26605
MRPL16 mitochondrial ribosomal protein L16 2.2571
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.24995
CFAP44 cilia and flagella associated protein 44 2.2315
TSNAXIP1 translin-associated factor X interacting protein 1 2.2297
CYCS cytochrome c, somatic 2.22235
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 2.2023
CA8 carbonic anhydrase VIII 2.19765
AGBL2 ATP/GTP binding protein-like 2 2.1911
SMAD3 SMAD family member 3 2.17519
IQGAP1 IQ motif containing GTPase activating protein 1 2.1718
OLFML2A olfactomedin-like 2A 2.1631
SELENBP1 selenium binding protein 1 2.16285
NELL2 NEL-like 2 (chicken) 2.16115
MYF6 myogenic factor 6 (herculin) 2.15225
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.1485
DUSP14 dual specificity phosphatase 14 2.1429
LSM1 LSM1, U6 small nuclear RNA associated 2.14265
MED24 mediator complex subunit 24 2.1352
CRELD2 cysteine-rich with EGF-like domains 2 2.13345
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.1206
MORC3 MORC family CW-type zinc finger 3 2.1076
NT5DC2 5'-nucleotidase domain containing 2 2.10725
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.1068
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.10405
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.098
CA12 carbonic anhydrase XII 2.09546
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.09335
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.0896
NEK11 NIMA-related kinase 11 2.0887
CCL7 chemokine (C-C motif) ligand 7 2.08545
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 2.07477
BCL7B B-cell CLL/lymphoma 7B 2.062
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.0614
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.0571
ANKRD10 ankyrin repeat domain 10 2.053
SNAI1 snail family zinc finger 1 2.04845
IFT81 intraflagellar transport 81 2.04645
MSRA methionine sulfoxide reductase A 2.04565
AMIGO2 adhesion molecule with Ig-like domain 2 2.0442
HSPA12A heat shock 70kDa protein 12A 2.03645
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.03555
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.03465
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.02895
IL18R1 interleukin 18 receptor 1 2.0274
SPEF1 sperm flagellar 1 2.0245
UBE2M ubiquitin-conjugating enzyme E2M 2.0208
DRC9 dynein regulatory complex subunit 9 2.0189
FCGBP Fc fragment of IgG binding protein 2.0178
ZNF518A zinc finger protein 518A 2.0157
FBXO40 F-box protein 40 2.01025
TSGA10 testis specific, 10 2.00915
INPP5F inositol polyphosphate-5-phosphatase F 2.008
GYS1 glycogen synthase 1 (muscle) 2.0021
SCAF4 SR-related CTD-associated factor 4 2.00093
SLC35B1 solute carrier family 35, member B1 2.00065

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -7.9482
GOLT1B golgi transport 1B -6.957
VAT1 vesicle amine transport 1 -6.91275
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.85475
CCNB2 cyclin B2 -6.3095
NGRN neugrin, neurite outgrowth associated -5.51005
HMG20B high mobility group 20B -4.9779
ZW10 zw10 kinetochore protein -4.9234
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.34775
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.30575
USP6NL USP6 N-terminal like -4.2682
CD320 CD320 molecule -4.09315
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.07275
UBE3C ubiquitin protein ligase E3C -3.8969
GNAS GNAS complex locus -3.7654
PRCP prolylcarboxypeptidase (angiotensinase C) -3.66675
DSG2 desmoglein 2 -3.5964
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.5241
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.50312
NUP93 nucleoporin 93kDa -3.3541
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.31655
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.308
ETFB electron-transfer-flavoprotein, beta polypeptide -3.2248
ACAA1 acetyl-CoA acyltransferase 1 -3.21285
PECR peroxisomal trans-2-enoyl-CoA reductase -2.99375
FOS FBJ murine osteosarcoma viral oncogene homolog -2.9815
TM9SF2 transmembrane 9 superfamily member 2 -2.9554
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.9485
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.94338
HSPA1A heat shock 70kDa protein 1A -2.93485
HEATR1 HEAT repeat containing 1 -2.89792
RECQL4 RecQ protein-like 4 -2.86655
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.82325
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.7654
NECTIN3 nectin cell adhesion molecule 3 -2.7543
RGS2 regulator of G-protein signaling 2 -2.7349
GPR137B G protein-coupled receptor 137B -2.7078
SQOR sulfide quinone oxidoreductase -2.69565
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.6106
IFRD2 interferon-related developmental regulator 2 -2.58433
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.5788
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.5616
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.5528
AURKA aurora kinase A -2.547
SNX11 sorting nexin 11 -2.52082
ORC6 origin recognition complex, subunit 6 -2.50325
BORCS8 BLOC-1 related complex subunit 8 -2.483
HAT1 histone acetyltransferase 1 -2.4663
STAT1 signal transducer and activator of transcription 1, 91kDa -2.45549
LRRC41 leucine rich repeat containing 41 -2.4502
ZDHHC18 zinc finger, DHHC-type containing 18 -2.4261
ALOX15B arachidonate 15-lipoxygenase, type B -2.42045
S100A6 S100 calcium binding protein A6 -2.4136
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.40485
KIF14 kinesin family member 14 -2.3593
PLA1A phospholipase A1 member A -2.3557
KYAT3 kynurenine aminotransferase 3 -2.33115
IGFBP7 insulin-like growth factor binding protein 7 -2.32885
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.30495
CPE carboxypeptidase E -2.2953
RBM12B RNA binding motif protein 12B -2.29505
GID4 GID complex subunit 4 -2.28585
RAD54L RAD54-like (S. cerevisiae) -2.2793
JPT2 Jupiter microtubule associated homolog 2 -2.27792
HIRIP3 HIRA interacting protein 3 -2.2725
VSIG2 V-set and immunoglobulin domain containing 2 -2.2539
ICAM2 intercellular adhesion molecule 2 -2.25325
EDIL3 EGF-like repeats and discoidin I-like domains 3 -2.25045
FGD2 FYVE, RhoGEF and PH domain containing 2 -2.2393
TWNK twinkle mtDNA helicase -2.23425
MAPK13 mitogen-activated protein kinase 13 -2.23355
ZZZ3 zinc finger, ZZ-type containing 3 -2.2241
ATOX1 antioxidant 1 copper chaperone -2.2222
RAB21 RAB21, member RAS oncogene family -2.2105
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.2102
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.19575
DEFA4 defensin, alpha 4, corticostatin -2.1955
STAMBP STAM binding protein -2.19385
TROAP trophinin associated protein -2.1854
UBE2C ubiquitin-conjugating enzyme E2C -2.16975
AUP1 ancient ubiquitous protein 1 -2.15815
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.1508
SARAF store-operated calcium entry-associated regulatory factor -2.1452
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.14325
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.13855
RAP1GAP2 RAP1 GTPase activating protein 2 -2.12815
MID1IP1 MID1 interacting protein 1 -2.1088
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.10655
SCAMP2 secretory carrier membrane protein 2 -2.10025
PHC2 polyhomeotic homolog 2 (Drosophila) -2.09825
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.0968
MRPL11 mitochondrial ribosomal protein L11 -2.09525
RXYLT1 ribitol xylosyltransferase 1 -2.08015
RPL36 ribosomal protein L36 -2.0597
DYNLT3 dynein, light chain, Tctex-type 3 -2.05935
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.0561
TMEM184C transmembrane protein 184C -2.04955
SH3GL1 SH3-domain GRB2-like 1 -2.0412
EXD3 exonuclease 3'-5' domain containing 3 -2.04065
CCNH cyclin H -2.03905
ADIRF adipogenesis regulatory factor -2.01725
RWDD1 RWD domain containing 1 -2.00955
NDE1 nudE neurodevelopment protein 1 -2.00675