| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | promethazine 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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145 genes differentially expressed following the CRCGN011_HEPG2_24H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ALDOC | aldolase C, fructose-bisphosphate | 8.2977 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.72795 |
| ADRB2 | adrenoceptor beta 2, surface | 5.3493 |
| E2F2 | E2F transcription factor 2 | 5.16985 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 5.16415 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.7061 |
| ATP11B | ATPase, class VI, type 11B | 4.7059 |
| TLR4 | toll-like receptor 4 | 4.60655 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 4.46583 |
| PRR15L | proline rich 15-like | 4.4317 |
| ABHD4 | abhydrolase domain containing 4 | 4.2627 |
| RRAGA | Ras-related GTP binding A | 4.0334 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.86483 |
| SOAT2 | sterol O-acyltransferase 2 | 3.83137 |
| ABHD6 | abhydrolase domain containing 6 | 3.79728 |
| TCTN1 | tectonic family member 1 | 3.7693 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 3.7121 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 3.5201 |
| DENND2D | DENN/MADD domain containing 2D | 3.2626 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 3.26198 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.25288 |
| TRIB3 | tribbles pseudokinase 3 | 3.17995 |
| CYCS | cytochrome c, somatic | 3.1263 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 3.0835 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 3.05503 |
| JADE2 | jade family PHD finger 2 | 2.98682 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.98472 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.78975 |
| SLC25A46 | solute carrier family 25, member 46 | 2.78665 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 2.76095 |
| HMOX1 | heme oxygenase 1 | 2.68725 |
| ATP6V1B2 | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 | 2.6509 |
| STXBP1 | syntaxin binding protein 1 | 2.6472 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2.56199 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.49845 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.46705 |
| STAP2 | signal transducing adaptor family member 2 | 2.4626 |
| EIF6 | eukaryotic translation initiation factor 6 | 2.44495 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.42865 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.4197 |
| TPD52L2 | tumor protein D52-like 2 | 2.4086 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 2.35315 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.35255 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.34515 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 2.30765 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 2.2608 |
| STEAP4 | STEAP family member 4 | 2.244 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 2.228 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.22405 |
| EPHA3 | EPH receptor A3 | 2.19968 |
| ATP10D | ATPase, class V, type 10D | 2.193 |
| DHCR7 | 7-dehydrocholesterol reductase | 2.19025 |
| CORO1A | coronin, actin binding protein, 1A | 2.18225 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.16075 |
| SNX7 | sorting nexin 7 | 2.15705 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 2.13585 |
| MVK | mevalonate kinase | 2.12875 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | 2.12075 |
| SH3D19 | SH3 domain containing 19 | 2.1122 |
| FAT4 | FAT atypical cadherin 4 | 2.06115 |
| ZNF589 | zinc finger protein 589 | 2.05812 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 2.05713 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 2.05515 |
| TAC4 | tachykinin 4 (hemokinin) | 2.0493 |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 2.04262 |
| TMEM165 | transmembrane protein 165 | 2.04065 |
| MCM6 | minichromosome maintenance complex component 6 | 2.01585 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 2.0114 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 2.00805 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB1 | cyclin B1 | -5.26805 |
| ADI1 | acireductone dioxygenase 1 | -5.1665 |
| LDHD | lactate dehydrogenase D | -5.16005 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.1417 |
| MRPS16 | mitochondrial ribosomal protein S16 | -4.9014 |
| CD320 | CD320 molecule | -4.69355 |
| DPH2 | DPH2 homolog (S. cerevisiae) | -4.6328 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.5642 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -4.54757 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -4.1509 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -4.143 |
| RALGDS | ral guanine nucleotide dissociation stimulator | -3.78285 |
| SPAG4 | sperm associated antigen 4 | -3.68675 |
| GNAS | GNAS complex locus | -3.50108 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.49513 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.44615 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -3.2162 |
| HEATR1 | HEAT repeat containing 1 | -3.1726 |
| HAT1 | histone acetyltransferase 1 | -3.1438 |
| FASTKD5 | FAST kinase domains 5 | -3.08575 |
| KIF14 | kinesin family member 14 | -3.07285 |
| MTFR1 | mitochondrial fission regulator 1 | -3.04503 |
| MOK | MOK protein kinase | -3.0194 |
| CCNB2 | cyclin B2 | -2.9721 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.8573 |
| RGS2 | regulator of G-protein signaling 2 | -2.8331 |
| DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | -2.8275 |
| RNF167 | ring finger protein 167 | -2.79485 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -2.75655 |
| TOR1A | torsin family 1, member A (torsin A) | -2.7179 |
| NVL | nuclear VCP-like | -2.70295 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -2.6773 |
| RUVBL1 | RuvB-like AAA ATPase 1 | -2.6732 |
| CKAP2 | cytoskeleton associated protein 2 | -2.65755 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -2.5892 |
| SERF1A | small EDRK-rich factor 1A (telomeric) | -2.5566 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.54385 |
| PPCS | phosphopantothenoylcysteine synthetase | -2.5372 |
| GDF15 | growth differentiation factor 15 | -2.51805 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.4809 |
| JPT2 | Jupiter microtubule associated homolog 2 | -2.45407 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | -2.42795 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -2.3903 |
| MIS18A | MIS18 kinetochore protein A | -2.37105 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.356 |
| IER3 | immediate early response 3 | -2.3331 |
| PLK1 | polo-like kinase 1 | -2.3271 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.3011 |
| TP53RK | TP53 regulating kinase | -2.29675 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -2.27855 |
| AURKA | aurora kinase A | -2.26697 |
| MRPS31 | mitochondrial ribosomal protein S31 | -2.24647 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.2372 |
| GOLT1B | golgi transport 1B | -2.2341 |
| DCK | deoxycytidine kinase | -2.20455 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.19715 |
| ANAPC15 | anaphase promoting complex subunit 15 | -2.19675 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | -2.19645 |
| ORMDL2 | ORMDL sphingolipid biosynthesis regulator 2 | -2.1936 |
| CDK1 | cyclin-dependent kinase 1 | -2.19333 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -2.1389 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -2.1378 |
| CDCA3 | cell division cycle associated 3 | -2.13035 |
| NCS1 | neuronal calcium sensor 1 | -2.12235 |
| CCNA2 | cyclin A2 | -2.11275 |
| NUP85 | nucleoporin 85kDa | -2.1126 |
| KIF1A | kinesin family member 1A | -2.10615 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.1022 |
| TRIM39-RPP21 | TRIM39-RPP21 readthrough | -2.08465 |
| ENDOG | endonuclease G | -2.07425 |
| SLC35F2 | solute carrier family 35, member F2 | -2.06245 |
| WDR6 | WD repeat domain 6 | -2.04805 |
| LYRM2 | LYR motif containing 2 | -2.0367 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.02463 |
| CRIPT | cysteine-rich PDZ-binding protein | -2.01635 |
| KIF23 | kinesin family member 23 | -2.0058 |
