CRCGN011_HEPG2_24H:P09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description promethazine 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN011_HEPG2_24H:P09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.46595
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 5.2977
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.23725
UBQLN2 ubiquilin 2 5.21
BPHL biphenyl hydrolase-like (serine hydrolase) 4.9876
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.43055
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.3735
HDGFL3 HDGF like 3 4.31661
VAV3 vav 3 guanine nucleotide exchange factor 4.13968
PEX11A peroxisomal biogenesis factor 11 alpha 4.10885
TLR4 toll-like receptor 4 4.03715
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.77215
ZNF589 zinc finger protein 589 3.66155
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.50965
PRKCH protein kinase C, eta 3.48303
HLA-DRA major histocompatibility complex, class II, DR alpha 3.41365
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.3273
ALDOC aldolase C, fructose-bisphosphate 3.19915
CDK2 cyclin-dependent kinase 2 3.1834
RAB21 RAB21, member RAS oncogene family 2.74315
CDC45 cell division cycle 45 2.63685
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.60427
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.4818
COQ8A coenzyme Q8A 2.4447
SOAT2 sterol O-acyltransferase 2 2.43535
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.42875
COL11A1 collagen, type XI, alpha 1 2.38447
GPATCH8 G patch domain containing 8 2.36722
RBBP5 retinoblastoma binding protein 5 2.30825
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.23315
ELOVL6 ELOVL fatty acid elongase 6 2.17163
TCTN1 tectonic family member 1 2.16715
LHFPL6 LHFPL tetraspan subfamily member 6 2.10225
ARPP19 cAMP-regulated phosphoprotein, 19kDa 2.08808
COG4 component of oligomeric golgi complex 4 2.03985

decreased expression

Symbol Name Standardized Value
BMP4 bone morphogenetic protein 4 -5.3247
LDHD lactate dehydrogenase D -5.048
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.7479
PSRC1 proline/serine-rich coiled-coil 1 -4.60155
GDF15 growth differentiation factor 15 -4.47405
CHMP4B charged multivesicular body protein 4B -3.90155
TRIB3 tribbles pseudokinase 3 -3.81925
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.5638
PCNA proliferating cell nuclear antigen -3.46325
TCERG1 transcription elongation regulator 1 -3.4576
GNAS GNAS complex locus -3.19131
HEATR1 HEAT repeat containing 1 -2.66425
TLCD3A TLC domain containing 3A -2.6568
AURKA aurora kinase A -2.61893
NUP88 nucleoporin 88kDa -2.31
CAB39 calcium binding protein 39 -2.2511
SLC35F2 solute carrier family 35, member F2 -2.21115
DCK deoxycytidine kinase -2.1932
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.18575
NDC80 NDC80 kinetochore complex component -2.1485
KIF14 kinesin family member 14 -2.12025
ADGRB2 adhesion G protein-coupled receptor B2 -2.1045
SQOR sulfide quinone oxidoreductase -2.06345
PLK1 polo-like kinase 1 -2.0433
PRRX2 paired related homeobox 2 -2.0346
CDK6 cyclin-dependent kinase 6 -2.03315
STRN4 striatin, calmodulin binding protein 4 -2.0276
PCCB propionyl CoA carboxylase, beta polypeptide -2.0256
IER3 immediate early response 3 -2.0075