CRCGN011_HEPG2_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description promethazine 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN011_HEPG2_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 10.0
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.4283
TATDN2 TatD DNase domain containing 2 4.96185
TLR4 toll-like receptor 4 4.5653
PRKCH protein kinase C, eta 3.79873
ATP11B ATPase, class VI, type 11B 3.5584
PLSCR3 phospholipid scramblase 3 3.48567
RNF167 ring finger protein 167 3.2846
PFKL phosphofructokinase, liver 3.26583
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.99675
CCNF cyclin F 2.9032
ARID4B AT rich interactive domain 4B (RBP1-like) 2.49545
MAST2 microtubule associated serine/threonine kinase 2 2.43025
CAPN15 calpain 15 2.3978
BMP4 bone morphogenetic protein 4 2.39705
DOK4 docking protein 4 2.31888
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.2896
BBS7 Bardet-Biedl syndrome 7 2.24365
GCLM glutamate-cysteine ligase, modifier subunit 2.24235
CCNA1 cyclin A1 2.21395
SLC25A46 solute carrier family 25, member 46 2.2093
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.1782
FLNA filamin A, alpha 2.17463
ATG2A autophagy related 2A 2.1437
RYR1 ryanodine receptor 1 (skeletal) 2.14025
SORBS3 sorbin and SH3 domain containing 3 2.12555
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.1169
CCP110 centriolar coiled coil protein 110kDa 2.1148
NBPF3 neuroblastoma breakpoint family, member 3 2.11295
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.04165
HOXA7 homeobox A7 2.0355
ITM2A integral membrane protein 2A 2.0343
ARL8B ADP-ribosylation factor-like 8B 2.01985

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.20922
HAT1 histone acetyltransferase 1 -5.34625
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.2879
PCCB propionyl CoA carboxylase, beta polypeptide -5.27125
TRIB3 tribbles pseudokinase 3 -5.14015
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.1075
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.0596
KDM3A lysine (K)-specific demethylase 3A -4.9437
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.94015
ZMIZ1 zinc finger, MIZ-type containing 1 -4.5201
ADI1 acireductone dioxygenase 1 -4.3856
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.65995
YME1L1 YME1-like 1 ATPase -3.40342
BLNK B-cell linker -2.8385
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.824
TLCD3A TLC domain containing 3A -2.79305
CTNND1 catenin (cadherin-associated protein), delta 1 -2.69622
SLC35F2 solute carrier family 35, member F2 -2.49135
CD320 CD320 molecule -2.48865
SNX11 sorting nexin 11 -2.488
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.4747
LY86 lymphocyte antigen 86 -2.37055
YAF2 YY1 associated factor 2 -2.35025
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.31115
GMNN geminin, DNA replication inhibitor -2.2418
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.2117
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.1703
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.15973
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.12005
COX7B cytochrome c oxidase subunit VIIb -2.10035
PELO pelota homolog (Drosophila) -2.0969
MTPAP mitochondrial poly(A) polymerase -2.0918
OSBPL10 oxysterol binding protein-like 10 -2.07335
RAP2C RAP2C, member of RAS oncogene family -2.07072
BMPR1A bone morphogenetic protein receptor, type IA -2.0611
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.0597
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.0211
COXFA4 cytochrome c oxidase associated subunit FA4 -2.0116