CRCGN011_HEPG2_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description promethazine 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

127 genes differentially expressed following the CRCGN011_HEPG2_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.27595
NMU neuromedin U 5.27315
MSRA methionine sulfoxide reductase A 5.1346
CHMP6 charged multivesicular body protein 6 5.08545
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.8373
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.7631
LAGE3 L antigen family, member 3 4.579
PLSCR1 phospholipid scramblase 1 4.45323
BIRC2 baculoviral IAP repeat containing 2 3.9923
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.96785
MEST mesoderm specific transcript 3.69935
GSTZ1 glutathione S-transferase zeta 1 3.1536
SSBP2 single-stranded DNA binding protein 2 3.13775
SKIC2 SKI2 subunit of superkiller complex 2.9825
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.84555
SCRN1 secernin 1 2.7928
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.74252
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.65785
IFI44L interferon-induced protein 44-like 2.58725
GDI1 GDP dissociation inhibitor 1 2.5787
PRAF2 PRA1 domain family, member 2 2.55825
CALU calumenin 2.5043
DIPK1A divergent protein kinase domain 1A 2.49662
TIAM1 T-cell lymphoma invasion and metastasis 1 2.39885
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.39875
RAB23 RAB23, member RAS oncogene family 2.31775
CADPS2 Ca++-dependent secretion activator 2 2.2577
ISG15 ISG15 ubiquitin-like modifier 2.2406
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 2.2339
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.21735
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.21495
SLC10A3 solute carrier family 10, member 3 2.2057
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.20388
IPO13 importin 13 2.1903
PHF11 PHD finger protein 11 2.1763
SEC16A SEC16 homolog A (S. cerevisiae) 2.1544
OLFML3 olfactomedin-like 3 2.12525
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.11557
COPG1 coatomer protein complex, subunit gamma 1 2.06745
TRIM9 tripartite motif containing 9 2.0496
TMEM184B transmembrane protein 184B 2.04375
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.0287

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.70685
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.0737
ISOC1 isochorismatase domain containing 1 -4.9888
DNM1L dynamin 1-like -4.8722
USP6NL USP6 N-terminal like -4.75265
LDHD lactate dehydrogenase D -4.68755
CDC20 cell division cycle 20 -4.66275
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.6396
C2CD5 C2 calcium-dependent domain containing 5 -4.53355
MAP7 microtubule-associated protein 7 -4.53045
FAIM Fas apoptotic inhibitory molecule -4.32905
FGFR4 fibroblast growth factor receptor 4 -4.12227
CCNB2 cyclin B2 -3.7992
GRWD1 glutamate-rich WD repeat containing 1 -3.61575
FASTKD5 FAST kinase domains 5 -3.42605
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -3.2848
NVL nuclear VCP-like -3.274
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.2113
DSG2 desmoglein 2 -3.16965
CDKN2AIP CDKN2A interacting protein -3.1188
PCNA proliferating cell nuclear antigen -2.93285
FBXO7 F-box protein 7 -2.91815
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.82005
H2BC3 H2B clustered histone 3 -2.7184
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -2.66265
AURKB aurora kinase B -2.6274
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.60235
DERA deoxyribose-phosphate aldolase (putative) -2.51175
AIDA axin interactor, dorsalization associated -2.5058
MFSD6 major facilitator superfamily domain containing 6 -2.50245
CDC42 cell division cycle 42 -2.49834
TEP1 telomerase-associated protein 1 -2.4806
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.47738
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.46435
PEDS1 plasmanylethanolamine desaturase 1 -2.45105
ETNK1 ethanolamine kinase 1 -2.42095
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.3865
TAPT1 transmembrane anterior posterior transformation 1 -2.30025
MBTD1 mbt domain containing 1 -2.2986
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -2.28725
RBM15B RNA binding motif protein 15B -2.2865
IQSEC3 IQ motif and Sec7 domain 3 -2.28555
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.2833
GNS glucosamine (N-acetyl)-6-sulfatase -2.28328
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -2.2768
CREBL2 cAMP responsive element binding protein-like 2 -2.26692
VIL1 villin 1 -2.2391
PEX26 peroxisomal biogenesis factor 26 -2.23355
DNASE2B deoxyribonuclease II beta -2.23155
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.22475
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.21613
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.20555
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.20472
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.20465
ZNF154 zinc finger protein 154 -2.19955
IL2RG interleukin 2 receptor, gamma -2.177
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.171
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.1617
CYB5RL cytochrome b5 reductase-like -2.1613
SLAMF8 SLAM family member 8 -2.15595
MED21 mediator complex subunit 21 -2.1461
ZNF586 zinc finger protein 586 -2.14395
RESF1 retroelement silencing factor 1 -2.13535
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.12405
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.11455
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.1099
FEV FEV (ETS oncogene family) -2.10235
RFX3 regulatory factor X, 3 (influences HLA class II expression) -2.10135
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.08485
OARD1 O-acyl-ADP-ribose deacylase 1 -2.0823
MYO5C myosin VC -2.07755
PROX1 prospero homeobox 1 -2.07575
ZNF506 zinc finger protein 506 -2.06115
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.05715
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.0465
ZNF280D zinc finger protein 280D -2.0424
GOLGA6B golgin A6 family, member B -2.04035
VENTX VENT homeobox -2.03735
IL2RA interleukin 2 receptor, alpha -2.03167
AGPS alkylglycerone phosphate synthase -2.0312
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.03035
NLRP2 NLR family, pyrin domain containing 2 -2.0259
CHIC2 cysteine-rich hydrophobic domain 2 -2.01365