CRCGN011_HEPG2_24H:P13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(4-aminobenzyl)phenylamine 20.17 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN011_HEPG2_24H:P13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.5053
CIAO3 cytosolic iron-sulfur assembly component 3 5.33355
PPARG peroxisome proliferator-activated receptor gamma 4.74615
TLR4 toll-like receptor 4 4.46215
LOC122526780 uncharacterized LOC122526780 3.96145
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.181
RNF167 ring finger protein 167 2.68305
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.57605
NVL nuclear VCP-like 2.48215
CNPY3 canopy FGF signaling regulator 3 2.45075
INSIG1 insulin induced gene 1 2.36735
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.35615
TRIM13 tripartite motif containing 13 2.30825
CLBA1 clathrin binding box of aftiphilin containing 1 2.1579
HSPA1A heat shock 70kDa protein 1A 2.09285
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.04515

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
GNAS GNAS complex locus -7.50664
ADI1 acireductone dioxygenase 1 -5.11005
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.8797
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.11965
CDC25B cell division cycle 25B -3.86115
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.09923
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.74715
PSRC1 proline/serine-rich coiled-coil 1 -2.6617
CDC42 cell division cycle 42 -2.39371
ECHDC2 enoyl CoA hydratase domain containing 2 -2.36785
WNT16 wingless-type MMTV integration site family, member 16 -2.3658
DDIT4 DNA-damage-inducible transcript 4 -2.31555
PRSS58 protease, serine, 58 -2.2475
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.1931
CTRB2 chymotrypsinogen B2 -2.1409
TRIL TLR4 interactor with leucine-rich repeats -2.10693
RUVBL1 RuvB-like AAA ATPase 1 -2.0797
BCAP29 B-cell receptor-associated protein 29 -2.07955
CPA1 carboxypeptidase A1 (pancreatic) -2.06785
HCFC2 host cell factor C2 -2.06305
MEX3C mex-3 RNA binding family member C -2.0417
SKI SKI proto-oncogene -2.03485
CELA3B chymotrypsin-like elastase family, member 3B -2.0207
CELA3A chymotrypsin-like elastase family, member 3A -2.01275