CRCGN011_HEPG2_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(4-aminobenzyl)phenylamine 10.09 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN011_HEPG2_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 9.18005
EAPP E2F-associated phosphoprotein 5.0289
MSRA methionine sulfoxide reductase A 5.0
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.93185
CSK c-src tyrosine kinase 4.91515
LOC122526780 uncharacterized LOC122526780 4.9149
PPARG peroxisome proliferator-activated receptor gamma 4.8277
EPHB2 EPH receptor B2 4.17924
CYCS cytochrome c, somatic 3.481
HSPA1A heat shock 70kDa protein 1A 3.22265
CCNF cyclin F 3.09882
CEP57 centrosomal protein 57kDa 3.00381
JADE2 jade family PHD finger 2 2.87135
SSBP2 single-stranded DNA binding protein 2 2.7193
ADGRE5 adhesion G protein-coupled receptor E5 2.71735
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.6198
RBM14-RBM4 RBM14-RBM4 readthrough 2.3481
PTDSS1 phosphatidylserine synthase 1 2.10185
NTHL1 nth endonuclease III-like 1 (E. coli) 2.0718

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.18555
LDHD lactate dehydrogenase D -4.8382
C2CD5 C2 calcium-dependent domain containing 5 -4.50665
MAP7 microtubule-associated protein 7 -4.48993
GNAS GNAS complex locus -3.72652
WASHC4 WASH complex subunit 4 -3.39235
SLC35F2 solute carrier family 35, member F2 -3.16955
TLCD3A TLC domain containing 3A -3.09795
PCNA proliferating cell nuclear antigen -3.0955
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.77122
PRKACG protein kinase, cAMP-dependent, catalytic, gamma -2.64415
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.48145
DERA deoxyribose-phosphate aldolase (putative) -2.45915
RPS5 ribosomal protein S5 -2.44155
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -2.40955
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.36346
KRT34 keratin 34, type I -2.35875
FLT3 fms-related tyrosine kinase 3 -2.34405
SHCBP1L SHC SH2-domain binding protein 1-like -2.28965
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.23465
HOOK1 hook microtubule-tethering protein 1 -2.23245
LGALS7B lectin, galactoside-binding, soluble, 7B -2.19865
PDHX pyruvate dehydrogenase complex, component X -2.18755
HLA-DMA major histocompatibility complex, class II, DM alpha -2.18275
TGFBR1 transforming growth factor, beta receptor 1 -2.1803
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 -2.17975
KRT16 keratin 16, type I -2.17855
AKAP4 A kinase (PRKA) anchor protein 4 -2.16735
PRRX1 paired related homeobox 1 -2.14615
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.13445
LDHC lactate dehydrogenase C -2.10815
NR0B1 nuclear receptor subfamily 0, group B, member 1 -2.09507
LDHAL6B lactate dehydrogenase A-like 6B -2.08755
SCN4A sodium channel, voltage gated, type IV alpha subunit -2.07535
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -2.07225
DNAH17 dynein, axonemal, heavy chain 17 -2.05875
LEMD3 LEM domain containing 3 -2.04935
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.0445
FOS FBJ murine osteosarcoma viral oncogene homolog -2.04165
DDIT4 DNA-damage-inducible transcript 4 -2.0314
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.02588
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 -2.0089