CRCGN011_HEPG2_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(4-aminobenzyl)phenylamine 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN011_HEPG2_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NMU neuromedin U 5.8625
CARMIL1 capping protein regulator and myosin 1 linker 1 5.19995
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 5.102
NOTCH1 notch 1 4.98825
E2F2 E2F transcription factor 2 4.89325
STIMATE STIM activating enhancer 4.82515
UBQLN2 ubiquilin 2 4.7885
CIAO3 cytosolic iron-sulfur assembly component 3 4.75565
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.75365
STAP2 signal transducing adaptor family member 2 4.7015
PNKP polynucleotide kinase 3'-phosphatase 4.6027
PPARG peroxisome proliferator-activated receptor gamma 4.4587
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.3681
RPP38 ribonuclease P/MRP 38kDa subunit 4.05875
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.02819
PRKCH protein kinase C, eta 3.9595
GATA3 GATA binding protein 3 3.71398
GPER1 G protein-coupled estrogen receptor 1 3.19855
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.17545
FZD7 frizzled class receptor 7 2.91358
CHN1 chimerin 1 2.9111
KLHL9 kelch-like family member 9 2.8946
NOP53 NOP53 ribosome biogenesis factor 2.85855
SPRED2 sprouty-related, EVH1 domain containing 2 2.59632
IRX4 iroquois homeobox 4 2.5542
DIPK1A divergent protein kinase domain 1A 2.48027
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 2.43722
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.4311
RPL36A ribosomal protein L36a 2.39625
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.39384
CARM1 coactivator-associated arginine methyltransferase 1 2.374
TESPA1 thymocyte expressed, positive selection associated 1 2.36415
STMN3 stathmin-like 3 2.3177
ZNF274 zinc finger protein 274 2.2931
ANO3 anoctamin 3 2.2768
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.2625
CHEK2 checkpoint kinase 2 2.25525
ADAM15 ADAM metallopeptidase domain 15 2.19985
RAB3D RAB3D, member RAS oncogene family 2.188
HDAC4 histone deacetylase 4 2.1591
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.13285
TLX2 T-cell leukemia homeobox 2 2.12217
RPL18A ribosomal protein L18a 2.11515
TEF thyrotrophic embryonic factor 2.1022
NCLN nicalin 2.09655
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.0906
PRR15L proline rich 15-like 2.0898
COX6C cytochrome c oxidase subunit VIc 2.08715
ITGA9 integrin, alpha 9 2.07935
PHF13 PHD finger protein 13 2.0688
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.06655
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.05485
TSHZ2 teashirt zinc finger homeobox 2 2.0544
CDON cell adhesion associated, oncogene regulated 2.0405
ADTRP androgen-dependent TFPI-regulating protein 2.0349
XPO4 exportin 4 2.0343
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.0218
WDTC1 WD and tetratricopeptide repeats 1 2.01988
PRSS8 protease, serine, 8 2.0146
PRAMEF26 PRAME family member 26 2.01335
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.0107
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.00995
ELL elongation factor RNA polymerase II 2.00662
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.0011

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.4292
PLK1 polo-like kinase 1 -6.46565
TRIB3 tribbles pseudokinase 3 -5.4643
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.433
PCCB propionyl CoA carboxylase, beta polypeptide -5.40135
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.7479
CCDC86 coiled-coil domain containing 86 -4.70435
COG2 component of oligomeric golgi complex 2 -4.3414
EIF5 eukaryotic translation initiation factor 5 -4.13419
ADI1 acireductone dioxygenase 1 -3.92975
PEG10 paternally expressed 10 -3.7785
TLCD3A TLC domain containing 3A -3.5481
WASHC4 WASH complex subunit 4 -3.53273
CTNND1 catenin (cadherin-associated protein), delta 1 -3.51242
NRIP1 nuclear receptor interacting protein 1 -3.39738
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.375
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.18495
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.01195
RFWD3 ring finger and WD repeat domain 3 -2.7787
CDC25B cell division cycle 25B -2.6997
KRT10 keratin 10, type I -2.69938
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.59938
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.5148
PLSCR4 phospholipid scramblase 4 -2.26915
ITGB1BP1 integrin beta 1 binding protein 1 -2.2592
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.2211
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.2041
RAB32 RAB32, member RAS oncogene family -2.16045
FDXR ferredoxin reductase -2.09025
TOMM34 translocase of outer mitochondrial membrane 34 -2.0882
SNX24 sorting nexin 24 -2.08655
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -2.0823
RFC2 replication factor C (activator 1) 2, 40kDa -2.07745
PALB2 partner and localizer of BRCA2 -2.0522
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.043
SNX5 sorting nexin 5 -2.0112