CRCGN011_HEPG2_24H:P19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoin 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN011_HEPG2_24H:P19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.0
PPARG peroxisome proliferator-activated receptor gamma 4.96985
PNKP polynucleotide kinase 3'-phosphatase 4.8372
TREM1 triggering receptor expressed on myeloid cells 1 4.82105
EPHB2 EPH receptor B2 4.8175
BZW2 basic leucine zipper and W2 domains 2 4.3106
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 4.23147
MAP7 microtubule-associated protein 7 3.96038
KLHL9 kelch-like family member 9 3.56938
TLR4 toll-like receptor 4 3.5001
SSBP2 single-stranded DNA binding protein 2 3.44365
LOC122526780 uncharacterized LOC122526780 3.3628
CYCS cytochrome c, somatic 3.35155
HMOX1 heme oxygenase 1 3.0093
ATP11B ATPase, class VI, type 11B 2.84605
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.6283
KPTN kaptin (actin binding protein) 2.35655
MISP mitotic spindle positioning 2.263
CAAP1 caspase activity and apoptosis inhibitor 1 2.0796
NMU neuromedin U 2.05285
COX5A cytochrome c oxidase subunit Va 2.01235

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -5.465
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.2344
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.8199
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.76335
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.0512
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.78567
FGFR4 fibroblast growth factor receptor 4 -3.56177
TBC1D31 TBC1 domain family, member 31 -3.15355
ACAA1 acetyl-CoA acyltransferase 1 -3.03162
NRIP1 nuclear receptor interacting protein 1 -2.9845
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.87085
OXA1L oxidase (cytochrome c) assembly 1-like -2.5365
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.5039
STYK1 serine/threonine/tyrosine kinase 1 -2.44697
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.31435
GABRP gamma-aminobutyric acid (GABA) A receptor, pi -2.27775
CDC25B cell division cycle 25B -2.22795
TDRD12 tudor domain containing 12 -2.22195
TLCD3A TLC domain containing 3A -2.19675
SLC30A10 solute carrier family 30, member 10 -2.16035
ORM1 orosomucoid 1 -2.15005
DCAF6 DDB1 and CUL4 associated factor 6 -2.14255
ORM2 orosomucoid 2 -2.10835
SOAT2 sterol O-acyltransferase 2 -2.10283
EMCN endomucin -2.0876
IL9 interleukin 9 -2.0626
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 -2.0198
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.0083