CRCGN011_HEPG2_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoin 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

142 genes differentially expressed following the CRCGN011_HEPG2_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
TREM1 triggering receptor expressed on myeloid cells 1 5.7623
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.5813
MCOLN1 mucolipin 1 5.3678
PLS1 plastin 1 5.29565
CCDC92 coiled-coil domain containing 92 5.11815
E2F2 E2F transcription factor 2 5.0206
TLR4 toll-like receptor 4 4.98515
STAP2 signal transducing adaptor family member 2 4.84915
PPARG peroxisome proliferator-activated receptor gamma 4.68985
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.56845
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.538
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2534
PRKCH protein kinase C, eta 4.21485
RPL39L ribosomal protein L39-like 4.19155
STK10 serine/threonine kinase 10 4.1591
MAP7 microtubule-associated protein 7 3.98223
WDR7 WD repeat domain 7 3.5741
CHN1 chimerin 1 3.2806
TIAM1 T-cell lymphoma invasion and metastasis 1 3.1237
PROX1 prospero homeobox 1 2.9898
NOSIP nitric oxide synthase interacting protein 2.9402
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.7482
KCTD7 potassium channel tetramerization domain containing 7 2.73945
KNOP1 lysine-rich nucleolar protein 1 2.7389
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.60685
DYNLT3 dynein, light chain, Tctex-type 3 2.6059
ZNF83 zinc finger protein 83 2.5768
CD52 CD52 molecule 2.5575
CRYBA4 crystallin, beta A4 2.5483
HMOX1 heme oxygenase 1 2.54445
CGRRF1 cell growth regulator with ring finger domain 1 2.539
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.5089
BMP6 bone morphogenetic protein 6 2.50345
POU4F1 POU class 4 homeobox 1 2.47635
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.4478
GPATCH8 G patch domain containing 8 2.4471
TMEM100 transmembrane protein 100 2.4132
SAP30L SAP30-like 2.39485
TGFB3 transforming growth factor, beta 3 2.37225
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.35665
HLA-DRA major histocompatibility complex, class II, DR alpha 2.35577
CEP72 centrosomal protein 72kDa 2.33735
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.33255
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.32065
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.29255
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.2818
MCRS1 microspherule protein 1 2.26125
KRT33B keratin 33B, type I 2.25995
NECAP2 NECAP endocytosis associated 2 2.2586
RNF13 ring finger protein 13 2.24007
KLHL4 kelch-like family member 4 2.23225
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.231
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 2.2201
SKAP1 src kinase associated phosphoprotein 1 2.2134
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.20445
RBMXL2 RNA binding motif protein, X-linked-like 2 2.18885
PLXDC2 plexin domain containing 2 2.17405
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 2.16963
INTS7 integrator complex subunit 7 2.16447
TBXA2R thromboxane A2 receptor 2.16118
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.1555
ZSCAN16 zinc finger and SCAN domain containing 16 2.14785
PFDN6 prefoldin subunit 6 2.086
FTSJ3 FtsJ homolog 3 (E. coli) 2.0859
PNPLA6 patatin-like phospholipase domain containing 6 2.07655
MISP mitotic spindle positioning 2.07605
GLP2R glucagon-like peptide 2 receptor 2.0686
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.0663
ANO3 anoctamin 3 2.0604
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.0564
INPPL1 inositol polyphosphate phosphatase-like 1 2.0504
ATXN3 ataxin 3 2.04973
CDH20 cadherin 20, type 2 2.0443
LGALSL lectin, galactoside-binding-like 2.04245
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta 2.0375
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.0205
EFL1 elongation factor like GTPase 1 2.0143
CCL15 chemokine (C-C motif) ligand 15 2.01385
EMP1 epithelial membrane protein 1 2.00912
DMTF1 cyclin D binding myb-like transcription factor 1 2.00758
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.00655
ITGA1 integrin, alpha 1 2.0041

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CDC20 cell division cycle 20 -5.31545
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.16735
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.072
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.81815
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.7967
PCNA proliferating cell nuclear antigen -4.66275
TMEM50A transmembrane protein 50A -4.65295
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.5486
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.4224
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.39825
OXA1L oxidase (cytochrome c) assembly 1-like -4.20405
NGRN neugrin, neurite outgrowth associated -4.15285
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.92285
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.5171
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.4709
NRIP1 nuclear receptor interacting protein 1 -3.3735
ADI1 acireductone dioxygenase 1 -3.0539
GDF15 growth differentiation factor 15 -2.9909
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.94995
TCERG1 transcription elongation regulator 1 -2.78955
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.71195
NUP54 nucleoporin 54kDa -2.66845
MT1E metallothionein 1E -2.65795
MT1F metallothionein 1F -2.5821
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.56487
SLC12A8 solute carrier family 12, member 8 -2.5465
WDR91 WD repeat domain 91 -2.4791
LRRC41 leucine rich repeat containing 41 -2.4433
PRPF4 pre-mRNA processing factor 4 -2.43095
PGM1 phosphoglucomutase 1 -2.42625
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.39725
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.38652
CCNC cyclin C -2.36415
LY6E lymphocyte antigen 6 complex, locus E -2.2775
PREB prolactin regulatory element binding -2.25775
MTMR6 myotubularin related protein 6 -2.24835
RGS2 regulator of G-protein signaling 2 -2.22685
RNF4 ring finger protein 4 -2.22285
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.2225
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.22175
TRIP6 thyroid hormone receptor interactor 6 -2.20855
STOML2 stomatin (EPB72)-like 2 -2.1937
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.18905
MT1G metallothionein 1G -2.1839
PFAS phosphoribosylformylglycinamidine synthase -2.157
ADCY1 adenylate cyclase 1 (brain) -2.14447
ARL4D ADP-ribosylation factor-like 4D -2.11155
RAB38 RAB38, member RAS oncogene family -2.1024
ACO2 aconitase 2, mitochondrial -2.101
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.09345
CORO1C coronin, actin binding protein, 1C -2.0887
SH2B3 SH2B adaptor protein 3 -2.07965
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.0657
COL6A3 collagen, type VI, alpha 3 -2.03905
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.03555
STX12 syntaxin 12 -2.0155
CD248 CD248 molecule, endosialin -2.0153
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -2.01017