CRCGN011_HEPG2_24H:P23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoin 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:P23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.41
MYLK myosin light chain kinase 5.32905
CSK c-src tyrosine kinase 4.91515
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.75785
ABHD4 abhydrolase domain containing 4 3.6817
MAP7 microtubule-associated protein 7 3.41303
TLR4 toll-like receptor 4 3.30905
SSBP2 single-stranded DNA binding protein 2 2.93547
TMEM109 transmembrane protein 109 2.78295
HOOK2 hook microtubule-tethering protein 2 2.7232
ARL2 ADP-ribosylation factor-like 2 2.6313
GPATCH8 G patch domain containing 8 2.538
JADE2 jade family PHD finger 2 2.51953
LYN LYN proto-oncogene, Src family tyrosine kinase 2.50028
PRAF2 PRA1 domain family, member 2 2.433
CCNF cyclin F 2.42042
TMED1 transmembrane emp24 protein transport domain containing 1 2.3303
CHEK2 checkpoint kinase 2 2.3187
COL9A3 collagen, type IX, alpha 3 2.25055
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.1864
CD40 CD40 molecule, TNF receptor superfamily member 5 2.16646
TRAM2 translocation associated membrane protein 2 2.12488
MANBA mannosidase, beta A, lysosomal 2.104
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.10315
EMC7 ER membrane protein complex subunit 7 2.0975
MCM3 minichromosome maintenance complex component 3 2.00135

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.32185
CDC20 cell division cycle 20 -5.0
LDHD lactate dehydrogenase D -4.73895
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.6547
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.49485
TES testin LIM domain protein -4.18517
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.6768
CHIC2 cysteine-rich hydrophobic domain 2 -3.62955
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.54823
PCNA proliferating cell nuclear antigen -3.0549
TBC1D31 TBC1 domain family, member 31 -2.95975
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.9261
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.75222
DSG2 desmoglein 2 -2.5665
ZNF586 zinc finger protein 586 -2.38395
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.35122
TWF2 twinfilin actin binding protein 2 -2.34305
PRPF4 pre-mRNA processing factor 4 -2.29958
TXK TXK tyrosine kinase -2.206
IL18R1 interleukin 18 receptor 1 -2.175
DDIT4 DNA-damage-inducible transcript 4 -2.15775
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 -2.1403
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.1194
JPH3 junctophilin 3 -2.08055
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -2.08025
TSGA10 testis specific, 10 -2.0794
RIT2 Ras-like without CAAX 2 -2.06825
PIBF1 progesterone immunomodulatory binding factor 1 -2.06065
LGMN legumain -2.0279
SLC35F2 solute carrier family 35, member F2 -2.0261
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.02045
MAPK13 mitogen-activated protein kinase 13 -2.02012
GPATCH2 G patch domain containing 2 -2.00505
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.0001