CRCGN012_HEPG2_24H:A04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN012_HEPG2_24H:A04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.59792
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.45454
CARMIL1 capping protein regulator and myosin 1 linker 1 4.40535
PPARG peroxisome proliferator-activated receptor gamma 4.21905
NOTCH1 notch 1 4.08137
PNKP polynucleotide kinase 3'-phosphatase 3.94813
EPHB2 EPH receptor B2 3.60934
CIAO3 cytosolic iron-sulfur assembly component 3 3.5474
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.51727
STK10 serine/threonine kinase 10 3.40411
STIMATE STIM activating enhancer 3.36031
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.35063
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.13952
CHMP6 charged multivesicular body protein 6 3.00524
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.8775
ADRB2 adrenoceptor beta 2, surface 2.83445
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.72028
ANO1 anoctamin 1, calcium activated chloride channel 2.62019
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.55819
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.54801
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.48009
SOCS2 suppressor of cytokine signaling 2 2.37485
PRKCH protein kinase C, eta 2.30692
PMM2 phosphomannomutase 2 2.26143
GPER1 G protein-coupled estrogen receptor 1 2.21122
ADAT1 adenosine deaminase, tRNA-specific 1 2.19276
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.0932
TIAM1 T-cell lymphoma invasion and metastasis 1 2.04941
RXYLT1 ribitol xylosyltransferase 1 2.04903
KIF20A kinesin family member 20A 2.0315

decreased expression

Symbol Name Standardized Value
FAIM Fas apoptotic inhibitory molecule -7.03439
CD320 CD320 molecule -5.08593
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.918
CDC20 cell division cycle 20 -4.47858
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.26081
OXA1L oxidase (cytochrome c) assembly 1-like -3.97487
CDC25B cell division cycle 25B -3.70689
DNM1L dynamin 1-like -3.32765
MAPK13 mitogen-activated protein kinase 13 -3.28499
CCNB2 cyclin B2 -2.77523
MAP7 microtubule-associated protein 7 -2.42975
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.38365
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.16454
MTERF4 mitochondrial transcription termination factor 4 -2.11747
USP6NL USP6 N-terminal like -2.11263
RAI14 retinoic acid induced 14 -2.06165
SCFD1 sec1 family domain containing 1 -2.02697
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.02235