CRCGN012_HEPG2_24H:A05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN012_HEPG2_24H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 8.70604
CAPN1 calpain 1, (mu/I) large subunit 4.74772
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.49305
UBQLN2 ubiquilin 2 4.43617
BTK Bruton agammaglobulinemia tyrosine kinase 4.38057
E2F2 E2F transcription factor 2 4.36444
SMIM40 small integral membrane protein 40 4.27036
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.23754
WDR7 WD repeat domain 7 4.21429
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.18395
PPARG peroxisome proliferator-activated receptor gamma 4.18252
LCN2 lipocalin 2 3.69069
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.68237
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.57348
CXCR4 chemokine (C-X-C motif) receptor 4 3.56643
PCDHB11 protocadherin beta 11 3.50482
NT5DC2 5'-nucleotidase domain containing 2 3.49944
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.49029
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.44357
CCDC86 coiled-coil domain containing 86 3.07482
PCNA proliferating cell nuclear antigen 2.98876
SLC75A1 solute carrier family 75 member 1 2.86638
MZB1 marginal zone B and B1 cell-specific protein 2.84354
NCF4 neutrophil cytosolic factor 4, 40kDa 2.84223
TBC1D31 TBC1 domain family, member 31 2.83154
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.80521
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.72782
INTS3 integrator complex subunit 3 2.7243
TIAM1 T-cell lymphoma invasion and metastasis 1 2.72418
GPATCH8 G patch domain containing 8 2.71524
CREG1 cellular repressor of E1A-stimulated genes 1 2.6383
CELF2 CUGBP, Elav-like family member 2 2.59925
DMAP1 DNA methyltransferase 1 associated protein 1 2.51737
PLSCR1 phospholipid scramblase 1 2.44497
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.38212
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2.3747
NMU neuromedin U 2.3645
FZD1 frizzled class receptor 1 2.34304
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.33809
SLAMF7 SLAM family member 7 2.32955
CENPU centromere protein U 2.25631
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.23008
ZBED2 zinc finger, BED-type containing 2 2.21425
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.19563
POU2AF1 POU class 2 associating factor 1 2.19045
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.16915
PADI3 peptidyl arginine deiminase, type III 2.16489
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.1635
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.15314
CD19 CD19 molecule 2.14203
EXTL2 exostosin-like glycosyltransferase 2 2.13404
LIAS lipoic acid synthetase 2.13083
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.13019
STK25 serine/threonine kinase 25 2.12934
TCL1A T-cell leukemia/lymphoma 1A 2.12613
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.12456
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.11252
ETV7 ets variant 7 2.09741
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.09711
CRTAM cytotoxic and regulatory T cell molecule 2.08322
CYTIP cytohesin 1 interacting protein 2.0822
CENPX centromere protein X 2.06646
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.05397
ZNF282 zinc finger protein 282 2.03532
CDK6 cyclin-dependent kinase 6 2.02358
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.02253
ZNF692 zinc finger protein 692 2.01851
ANKRD10 ankyrin repeat domain 10 2.00567
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.00369
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.00243

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -6.18246
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.28885
ARID5B AT rich interactive domain 5B (MRF1-like) -4.74498
KDM3A lysine (K)-specific demethylase 3A -4.64823
LDHD lactate dehydrogenase D -4.51543
VAT1 vesicle amine transport 1 -4.41179
SCAND1 SCAN domain containing 1 -4.33139
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.23173
PCCB propionyl CoA carboxylase, beta polypeptide -3.99319
SLC35F2 solute carrier family 35, member F2 -3.90877
VDAC1 voltage-dependent anion channel 1 -3.73823
TM9SF3 transmembrane 9 superfamily member 3 -3.71699
GNAS GNAS complex locus -3.56539
OXA1L oxidase (cytochrome c) assembly 1-like -3.54207
ZW10 zw10 kinetochore protein -3.53713
CTSD cathepsin D -3.30769
EAPP E2F-associated phosphoprotein -3.19776
CRYZ crystallin, zeta (quinone reductase) -3.1143
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.90338
NUP93 nucleoporin 93kDa -2.84157
GLOD4 glyoxalase domain containing 4 -2.77833
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.69819
SQOR sulfide quinone oxidoreductase -2.55797
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.52868
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.45274
PRPF4 pre-mRNA processing factor 4 -2.43537
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.43453
MPC1 mitochondrial pyruvate carrier 1 -2.39915
NGRN neugrin, neurite outgrowth associated -2.3166
PRCP prolylcarboxypeptidase (angiotensinase C) -2.29411
CIB1 calcium and integrin binding 1 (calmyrin) -2.25722
ACOT8 acyl-CoA thioesterase 8 -2.25096
DYNLT3 dynein, light chain, Tctex-type 3 -2.24384
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.17911
SCML1 sex comb on midleg-like 1 (Drosophila) -2.15728
GYG1 glycogenin 1 -2.1522
LAGE3 L antigen family, member 3 -2.14504
F8A2 coagulation factor VIII-associated 2 -2.13412
GABARAP GABA(A) receptor-associated protein -2.121
GOLT1B golgi transport 1B -2.11285
AHCY adenosylhomocysteinase -2.06522
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.06102
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.05766
SAR1B secretion associated, Ras related GTPase 1B -2.04803
ADAMTSL3 ADAMTS-like 3 -2.04269
TRPS1 trichorhinophalangeal syndrome I -2.03916
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -2.03618
GOLT1A golgi transport 1A -2.0316
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.01906
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.00496
QARS1 glutaminyl-tRNA synthetase 1 -2.00407