CRCGN012_HEPG2_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN012_HEPG2_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 6.80025
STK10 serine/threonine kinase 10 5.98671
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.73292
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.54937
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.32071
VGLL4 vestigial-like family member 4 3.89997
NT5DC2 5'-nucleotidase domain containing 2 3.52203
PLS1 plastin 1 3.38382
MYLK myosin light chain kinase 3.38299
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.34376
HOXA10 homeobox A10 3.30256
CHEK2 checkpoint kinase 2 3.20881
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.14202
CSK c-src tyrosine kinase 3.02079
GSTZ1 glutathione S-transferase zeta 1 2.97741
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.97415
LOC122526780 uncharacterized LOC122526780 2.56182
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.47202
ZNF318 zinc finger protein 318 2.47095
RRAGA Ras-related GTP binding A 2.42177
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.41846
MEST mesoderm specific transcript 2.40456
COG2 component of oligomeric golgi complex 2 2.39244
ATP11B ATPase, class VI, type 11B 2.38778
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.38246
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.36946
DYNLT3 dynein, light chain, Tctex-type 3 2.35343
PIH1D1 PIH1 domain containing 1 2.34382
CCDC86 coiled-coil domain containing 86 2.33725
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.30123
GATA3 GATA binding protein 3 2.28065
E2F5 E2F transcription factor 5, p130-binding 2.19326
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.17949
CHMP6 charged multivesicular body protein 6 2.10622
ICAM1 intercellular adhesion molecule 1 2.10112
GPATCH8 G patch domain containing 8 2.04439
N4BP3 NEDD4 binding protein 3 2.02322
WDR41 WD repeat domain 41 2.02034
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.00645

decreased expression

Symbol Name Standardized Value
SCAND1 SCAN domain containing 1 -5.87939
SLC35F2 solute carrier family 35, member F2 -5.1306
TLCD3A TLC domain containing 3A -4.67522
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.23108
PCNA proliferating cell nuclear antigen -4.0045
CAB39 calcium binding protein 39 -3.87521
LDHD lactate dehydrogenase D -3.86941
ZW10 zw10 kinetochore protein -3.51238
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.3535
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.34048
ADI1 acireductone dioxygenase 1 -3.33337
MAPK13 mitogen-activated protein kinase 13 -3.2427
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.03838
CRYZ crystallin, zeta (quinone reductase) -2.9842
EGF epidermal growth factor -2.93473
NGRN neugrin, neurite outgrowth associated -2.86986
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.60719
TOMM34 translocase of outer mitochondrial membrane 34 -2.57313
CDC20 cell division cycle 20 -2.49849
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.46725
CGRRF1 cell growth regulator with ring finger domain 1 -2.44995
EBNA1BP2 EBNA1 binding protein 2 -2.40368
REEP5 receptor accessory protein 5 -2.39005
VDAC1 voltage-dependent anion channel 1 -2.32743
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.20535
MTFR1 mitochondrial fission regulator 1 -2.12278
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.11516
SNX11 sorting nexin 11 -2.10617
GOLT1B golgi transport 1B -2.06021
DNM1L dynamin 1-like -2.0274
BCAR3 breast cancer anti-estrogen resistance 3 -2.02634