CRCGN012_HEPG2_24H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-p-toluidine 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN012_HEPG2_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 5.56221
ANO1 anoctamin 1, calcium activated chloride channel 5.05151
C2CD2 C2 calcium-dependent domain containing 2 5.0195
MYLK myosin light chain kinase 4.9949
STIMATE STIM activating enhancer 4.95553
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.92488
CARMIL1 capping protein regulator and myosin 1 linker 1 4.81422
UBQLN2 ubiquilin 2 4.70335
LCN2 lipocalin 2 4.55697
CHMP6 charged multivesicular body protein 6 4.4757
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.36847
CSK c-src tyrosine kinase 4.23375
CCNA1 cyclin A1 4.16732
EPHB2 EPH receptor B2 3.97149
SNAP25 synaptosomal-associated protein, 25kDa 3.80226
CCL2 chemokine (C-C motif) ligand 2 3.60803
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.31726
PRKCH protein kinase C, eta 3.30263
WDTC1 WD and tetratricopeptide repeats 1 3.01962
VGLL4 vestigial-like family member 4 3.00341
ICMT isoprenylcysteine carboxyl methyltransferase 2.8394
CREG1 cellular repressor of E1A-stimulated genes 1 2.79338
JADE2 jade family PHD finger 2 2.76842
CYCS cytochrome c, somatic 2.71914
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.69849
PCNA proliferating cell nuclear antigen 2.51106
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.25495
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.2463
RGN regucalcin 2.21253
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.21023
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.1982
DHCR7 7-dehydrocholesterol reductase 2.18262
OSBPL9 oxysterol binding protein-like 9 2.17841
KIF20A kinesin family member 20A 2.07308
BBS1 Bardet-Biedl syndrome 1 2.0425
ARID4B AT rich interactive domain 4B (RBP1-like) 2.004

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -7.91695
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.83672
TSPAN4 tetraspanin 4 -5.27434
MRPS2 mitochondrial ribosomal protein S2 -5.19045
DSG2 desmoglein 2 -5.11145
TRIB3 tribbles pseudokinase 3 -4.64549
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.25857
CCNB2 cyclin B2 -4.03232
CCNB1 cyclin B1 -3.94328
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.72044
CD320 CD320 molecule -3.70254
KRT8 keratin 8, type II -3.48052
CD58 CD58 molecule -3.10365
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.86587
RAI14 retinoic acid induced 14 -2.6866
IER3 immediate early response 3 -2.53173
MVP major vault protein -2.51025
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.29425
USP6NL USP6 N-terminal like -2.29099
TRAPPC6A trafficking protein particle complex 6A -2.26567
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.26126
FOS FBJ murine osteosarcoma viral oncogene homolog -2.21045
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.19297
MPC2 mitochondrial pyruvate carrier 2 -2.12121
NUP155 nucleoporin 155kDa -2.10719
KRT18 keratin 18, type I -2.07158
TRAP1 TNF receptor-associated protein 1 -2.0541
UPP1 uridine phosphorylase 1 -2.03123