CRCGN012_HEPG2_24H:A18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-p-toluidine 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN012_HEPG2_24H:A18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.87339
GPATCH8 G patch domain containing 8 5.50539
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.88297
BACE2 beta-site APP-cleaving enzyme 2 4.47365
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.44221
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.40037
CNPY3 canopy FGF signaling regulator 3 4.11289
ADGRE5 adhesion G protein-coupled receptor E5 4.06005
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.92835
E2F2 E2F transcription factor 2 3.86546
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.60751
NOTCH1 notch 1 3.57101
PEX11A peroxisomal biogenesis factor 11 alpha 3.49007
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.44112
CCL2 chemokine (C-C motif) ligand 2 3.24019
CDC45 cell division cycle 45 3.07837
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.03148
CHN1 chimerin 1 2.77709
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.73282
VIPR1 vasoactive intestinal peptide receptor 1 2.69058
HSPA1A heat shock 70kDa protein 1A 2.60616
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.59684
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.59083
GSTZ1 glutathione S-transferase zeta 1 2.57307
LOC122526780 uncharacterized LOC122526780 2.56883
GPAA1 glycosylphosphatidylinositol anchor attachment 1 2.4384
GYG2 glycogenin 2 2.42712
PEX6 peroxisomal biogenesis factor 6 2.35177
NVL nuclear VCP-like 2.32985
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.29351
HEBP1 heme binding protein 1 2.26367
IPO13 importin 13 2.23809
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.20084
TTC13 tetratricopeptide repeat domain 13 2.19031
CIDEC cell death-inducing DFFA-like effector c 2.18013
PTPRM protein tyrosine phosphatase, receptor type, M 2.15023
GNRH2 gonadotropin-releasing hormone 2 2.14552
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.0939
PLSCR3 phospholipid scramblase 3 2.02596
SPRED2 sprouty-related, EVH1 domain containing 2 2.01927

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.69429
CCNB2 cyclin B2 -5.04924
ADI1 acireductone dioxygenase 1 -4.6751
EGF epidermal growth factor -4.59417
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.42199
CDC25B cell division cycle 25B -4.22023
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.10513
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.99448
TLCD3A TLC domain containing 3A -3.83822
KDM3A lysine (K)-specific demethylase 3A -3.63535
SCAND1 SCAN domain containing 1 -3.61925
LAP3 leucine aminopeptidase 3 -3.49162
GNAS GNAS complex locus -3.48444
GLOD4 glyoxalase domain containing 4 -3.4337
SLC35F2 solute carrier family 35, member F2 -3.36627
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.34558
SNX11 sorting nexin 11 -3.1132
OXA1L oxidase (cytochrome c) assembly 1-like -2.90417
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.51458
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.35878
TRAP1 TNF receptor-associated protein 1 -2.24514
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.22624
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.12912
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.11951
NAPSA napsin A aspartic peptidase -2.0924
RTF2 replication termination factor 2 -2.08983
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -2.05067
MED28 mediator complex subunit 28 -2.04383
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.00951
EHD4 EH-domain containing 4 -2.00681