CRCGN012_HEPG2_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-anisidine.hcl 19.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN012_HEPG2_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 8.85084
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.5556
RPL39L ribosomal protein L39-like 4.53167
LCN2 lipocalin 2 4.42869
MINDY1 MINDY lysine 48 deubiquitinase 1 4.39215
ABHD4 abhydrolase domain containing 4 4.32884
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.28609
CHMP6 charged multivesicular body protein 6 4.25059
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.1107
PMM2 phosphomannomutase 2 3.64662
SNAP25 synaptosomal-associated protein, 25kDa 3.62039
E2F2 E2F transcription factor 2 3.39986
LPAR2 lysophosphatidic acid receptor 2 3.30214
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.26714
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.21005
IDE insulin-degrading enzyme 2.9304
CCL2 chemokine (C-C motif) ligand 2 2.87777
GPATCH8 G patch domain containing 8 2.80135
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.74456
KDM5A lysine (K)-specific demethylase 5A 2.74248
TIAM1 T-cell lymphoma invasion and metastasis 1 2.74058
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.6464
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.61933
HEBP1 heme binding protein 1 2.53932
EPHA3 EPH receptor A3 2.43438
ZDHHC18 zinc finger, DHHC-type containing 18 2.32899
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.24052
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.17863
KIAA1614 KIAA1614 2.15908
FSD1 fibronectin type III and SPRY domain containing 1 2.14175
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.13432
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.13142
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.12951
SLC46A3 solute carrier family 46, member 3 2.07644
ITGA7 integrin, alpha 7 2.03943
TEX10 testis expressed 10 2.01491
SNTA1 syntrophin, alpha 1 2.00131
CTSV cathepsin V 2.00033

decreased expression

Symbol Name Standardized Value
SMNDC1 survival motor neuron domain containing 1 -4.71679
TSPAN4 tetraspanin 4 -4.69025
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.51445
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.36584
CCNB2 cyclin B2 -4.29574
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.15666
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.11416
NT5DC2 5'-nucleotidase domain containing 2 -4.10058
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.96441
MAPK13 mitogen-activated protein kinase 13 -3.96351
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.82277
MAP7 microtubule-associated protein 7 -3.64493
EGF epidermal growth factor -3.6279
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.42519
ADI1 acireductone dioxygenase 1 -3.38176
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.15848
EIF5 eukaryotic translation initiation factor 5 -3.10042
NVL nuclear VCP-like -2.60135
MYL9 myosin, light chain 9, regulatory -2.57737
SELENBP1 selenium binding protein 1 -2.24491
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.23752
RAI14 retinoic acid induced 14 -2.07028
ZNF140 zinc finger protein 140 -2.00381