CRCGN012_HEPG2_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-anisidine.hcl 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN012_HEPG2_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.36385
CCDC92 coiled-coil domain containing 92 3.7012
CHMP6 charged multivesicular body protein 6 3.62958
DYNLT3 dynein, light chain, Tctex-type 3 3.49661
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.41765
CYCS cytochrome c, somatic 3.39592
RPL39L ribosomal protein L39-like 3.37874
C2CD2 C2 calcium-dependent domain containing 2 3.2688
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.2378
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.22516
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.09841
LCN2 lipocalin 2 3.05066
E2F2 E2F transcription factor 2 3.03054
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.91943
GSTZ1 glutathione S-transferase zeta 1 2.75344
PPARG peroxisome proliferator-activated receptor gamma 2.57856
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.55768
MTERF3 mitochondrial transcription termination factor 3 2.44419
SIRT3 sirtuin 3 2.41662
PRKCQ protein kinase C, theta 2.37946
CCL2 chemokine (C-C motif) ligand 2 2.32967
KLHL9 kelch-like family member 9 2.32745
ANO1 anoctamin 1, calcium activated chloride channel 2.29598
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.25525
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.23752
SFTPB surfactant protein B 2.23103
TUBB4B tubulin, beta 4B class IVb 2.1217
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.06708
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.04794

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
TLCD3A TLC domain containing 3A -4.14194
GTPBP8 GTP-binding protein 8 (putative) -3.9771
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.57967
SNX6 sorting nexin 6 -3.35296
UGDH UDP-glucose 6-dehydrogenase -3.09222
DNM1L dynamin 1-like -2.85404
IER3 immediate early response 3 -2.82454
ITGB1BP1 integrin beta 1 binding protein 1 -2.67664
NVL nuclear VCP-like -2.41275
TM9SF3 transmembrane 9 superfamily member 3 -2.3574
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.33548
RFC2 replication factor C (activator 1) 2, 40kDa -2.25937
DDIT4 DNA-damage-inducible transcript 4 -2.22419
NGRN neugrin, neurite outgrowth associated -2.21256
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.14142
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.1362
BCAP29 B-cell receptor-associated protein 29 -2.13295
BIRC2 baculoviral IAP repeat containing 2 -2.05408