CRCGN012_HEPG2_24H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumarin 20.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN012_HEPG2_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 10.0
TIAM1 T-cell lymphoma invasion and metastasis 1 5.22531
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.66752
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.58587
UBQLN2 ubiquilin 2 4.5375
HOXA10 homeobox A10 4.46374
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.85854
CSK c-src tyrosine kinase 3.70403
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.61344
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.57827
PEX11A peroxisomal biogenesis factor 11 alpha 3.55109
CHMP6 charged multivesicular body protein 6 3.25145
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.19941
LPAR2 lysophosphatidic acid receptor 2 3.18404
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.13006
STK10 serine/threonine kinase 10 2.90264
PRR15L proline rich 15-like 2.81167
SIRT3 sirtuin 3 2.80988
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.70174
CHN1 chimerin 1 2.54873
USP18 ubiquitin specific peptidase 18 2.39484
GPER1 G protein-coupled estrogen receptor 1 2.3893
HEBP1 heme binding protein 1 2.33765
ZNF273 zinc finger protein 273 2.31738
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.26479
DIPK1A divergent protein kinase domain 1A 2.24913
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.24023
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.22233
ECM1 extracellular matrix protein 1 2.14131
RFWD3 ring finger and WD repeat domain 3 2.12193
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.09341
IFI6 interferon, alpha-inducible protein 6 2.0635
ALG6 ALG6, alpha-1,3-glucosyltransferase 2.05979
PLIN3 perilipin 3 2.03539
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.01271
ADAT1 adenosine deaminase, tRNA-specific 1 2.00489

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.21102
LDHD lactate dehydrogenase D -4.55421
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.48895
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.93035
PDLIM1 PDZ and LIM domain 1 -3.68439
TCERG1 transcription elongation regulator 1 -2.67011
RAI14 retinoic acid induced 14 -2.54887
EIF5 eukaryotic translation initiation factor 5 -2.52856
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.47273
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.3748
CXCL2 chemokine (C-X-C motif) ligand 2 -2.35995
CERK ceramide kinase -2.16176
PTPRK protein tyrosine phosphatase, receptor type, K -2.15434
USP6NL USP6 N-terminal like -2.07245
PAGE1 P antigen family, member 1 (prostate associated) -2.01504