CRCGN012_HEPG2_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumarin 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN012_HEPG2_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.86383
SMIM40 small integral membrane protein 40 5.69891
TBC1D10C TBC1 domain family, member 10C 5.68326
ADRB2 adrenoceptor beta 2, surface 5.61217
TAC4 tachykinin 4 (hemokinin) 4.99669
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.87863
DENND2D DENN/MADD domain containing 2D 4.84747
LYN LYN proto-oncogene, Src family tyrosine kinase 4.65511
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.61606
CIAO3 cytosolic iron-sulfur assembly component 3 4.51249
AMDHD2 amidohydrolase domain containing 2 4.39473
E2F2 E2F transcription factor 2 4.34837
MCOLN1 mucolipin 1 4.19886
DYNLT3 dynein, light chain, Tctex-type 3 4.14971
PPARG peroxisome proliferator-activated receptor gamma 4.05997
STXBP1 syntaxin binding protein 1 3.78642
CSK c-src tyrosine kinase 3.76119
SQOR sulfide quinone oxidoreductase 3.34498
FZD7 frizzled class receptor 7 3.20025
TIAM1 T-cell lymphoma invasion and metastasis 1 3.1932
GSTZ1 glutathione S-transferase zeta 1 3.15284
ZNF589 zinc finger protein 589 3.09351
ABHD6 abhydrolase domain containing 6 3.03422
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.00182
MCM3 minichromosome maintenance complex component 3 2.91141
MAP7 microtubule-associated protein 7 2.85332
AXIN1 axin 1 2.7381
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.69858
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.66874
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.63916
GATA3 GATA binding protein 3 2.60466
CHEK2 checkpoint kinase 2 2.53586
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.52216
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.51741
PLSCR3 phospholipid scramblase 3 2.35546
PCDHB11 protocadherin beta 11 2.35291
PUS3 pseudouridylate synthase 3 2.31637
GPATCH8 G patch domain containing 8 2.31505
CCNF cyclin F 2.30754
LIN9 lin-9 DREAM MuvB core complex component 2.29188
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.22416
SRBD1 S1 RNA binding domain 1 2.20737
RIOK2 RIO kinase 2 2.2027
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.172
LUC7L LUC7-like (S. cerevisiae) 2.12647
CDC16 cell division cycle 16 2.10348
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.08424
TPD52-MRPS28 TPD52-MRPS28 readthrough 2.07151
EPHA3 EPH receptor A3 2.06817
THOC6 THO complex 6 2.06639
MYO19 myosin XIX 2.03521
RPAIN RPA interacting protein 2.03215
SASH1 SAM and SH3 domain containing 1 2.02029
BORA bora, aurora kinase A activator 2.01341
MTCL1 microtubule crosslinking factor 1 2.01241

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.73319
ITFG1 integrin alpha FG-GAP repeat containing 1 -8.193
CCNB2 cyclin B2 -7.6579
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.79484
KDM3A lysine (K)-specific demethylase 3A -4.7307
MRPS2 mitochondrial ribosomal protein S2 -4.6041
NT5DC2 5'-nucleotidase domain containing 2 -4.53216
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.38608
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.09321
MAPK13 mitogen-activated protein kinase 13 -4.07492
PEG10 paternally expressed 10 -3.99117
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.95622
YME1L1 YME1-like 1 ATPase -3.90234
PCNA proliferating cell nuclear antigen -3.68665
CHMP4B charged multivesicular body protein 4B -3.65925
ARID5B AT rich interactive domain 5B (MRF1-like) -3.21215
TLCD3A TLC domain containing 3A -2.84992
DDIT4 DNA-damage-inducible transcript 4 -2.73844
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.48555
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.42691
ACAA1 acetyl-CoA acyltransferase 1 -2.34838
MZT2B mitotic spindle organizing protein 2B -2.34005
TCTN1 tectonic family member 1 -2.33913
FCHO1 FCH domain only 1 -2.21939
TSPOAP1 TSPO associated protein 1 -2.20745
MRPL33 mitochondrial ribosomal protein L33 -2.20499
AKTIP AKT interacting protein -2.1946
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.17536
GPX4 glutathione peroxidase 4 -2.10508
FKBP3 FK506 binding protein 3, 25kDa -2.09024
NMRK1 nicotinamide riboside kinase 1 -2.08123
BTBD2 BTB (POZ) domain containing 2 -2.07478
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.07254
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.0657
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.03411
VASP vasodilator-stimulated phosphoprotein -2.00121