CRCGN012_HEPG2_24H:B16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4'-(chloroacetyl)acetanilide 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN012_HEPG2_24H:B16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 5.21073
RPL39L ribosomal protein L39-like 4.9388
CHN1 chimerin 1 4.31554
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.20279
NOSIP nitric oxide synthase interacting protein 3.9339
PPARG peroxisome proliferator-activated receptor gamma 3.90193
IDE insulin-degrading enzyme 3.68351
HOXA10 homeobox A10 3.62341
PRR15L proline rich 15-like 3.3925
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.14594
MICALL1 MICAL-like 1 2.74047
GPATCH8 G patch domain containing 8 2.68824
TEX10 testis expressed 10 2.50364
PRKCH protein kinase C, eta 2.36954
DIPK1A divergent protein kinase domain 1A 2.31622
ZNF589 zinc finger protein 589 2.22659
RAB21 RAB21, member RAS oncogene family 2.18672
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.16474
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.139
MXRA5 matrix-remodelling associated 5 2.10485
HYOU1 hypoxia up-regulated 1 2.09477

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.5227
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.30245
COG7 component of oligomeric golgi complex 7 -5.29084
ADI1 acireductone dioxygenase 1 -4.86784
CDC20 cell division cycle 20 -4.65802
LDHD lactate dehydrogenase D -4.46585
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.38373
GDF15 growth differentiation factor 15 -4.1595
KDM3A lysine (K)-specific demethylase 3A -3.80625
PSRC1 proline/serine-rich coiled-coil 1 -3.69431
EGF epidermal growth factor -2.97743
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.9416
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.77725
PEG10 paternally expressed 10 -2.75578
FN3K fructosamine 3 kinase -2.54068
GBX1 gastrulation brain homeobox 1 -2.51424
H4C7 H4 clustered histone 7 -2.47946
DOK3 docking protein 3 -2.45566
GTF2IRD2B GTF2I repeat domain containing 2B -2.39787
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -2.38182
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.36887
MVP major vault protein -2.35703
CFAP46 cilia and flagella associated protein 46 -2.3511
PLA2G15 phospholipase A2, group XV -2.33606
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.32221
TTLL1 tubulin tyrosine ligase-like family member 1 -2.31009
FSCN2 fascin actin-bundling protein 2, retinal -2.23617
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.22742
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.2179
WASHC4 WASH complex subunit 4 -2.20795
NLRP4 NLR family, pyrin domain containing 4 -2.18821
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.18791
FAM76A family with sequence similarity 76, member A -2.17886
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 -2.17716
PCDHA10 protocadherin alpha 10 -2.1607
VWA7 von Willebrand factor A domain containing 7 -2.15822
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.152
SNTG2 syntrophin, gamma 2 -2.14883
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.14555
PAX1 paired box 1 -2.14105
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.12853
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.12473
KDM8 lysine (K)-specific demethylase 8 -2.10603
TBL1Y transducin (beta)-like 1, Y-linked -2.10259
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -2.09276
TRPV4 transient receptor potential cation channel, subfamily V, member 4 -2.08908
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.08139
H3-4 H3.4 histone, cluster member -2.07639
ACAN aggrecan -2.0757
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.07524
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.07008
CCDC87 coiled-coil domain containing 87 -2.06153
MYO1F myosin IF -2.05642
EXTL1 exostosin-like glycosyltransferase 1 -2.05107
NXF3 nuclear RNA export factor 3 -2.05038
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.04813
OR10H2 olfactory receptor, family 10, subfamily H, member 2 -2.04703
IL25 interleukin 25 -2.0378
RNASE12 ribonuclease, RNase A family, 12 (non-active) -2.03314
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.02978
MC3R melanocortin 3 receptor -2.02519
GRK1 G protein-coupled receptor kinase 1 -2.02136
ADRA1D adrenoceptor alpha 1D -2.01773
RAG2 recombination activating gene 2 -2.01675
LRTM1 leucine-rich repeats and transmembrane domains 1 -2.01023
EPHA5 EPH receptor A5 -2.00917
ADM2 adrenomedullin 2 -2.00572
SCRT1 scratch family zinc finger 1 -2.00266
PAX3 paired box 3 -2.00106